Novel Aptamers Targeting Sclerostin Loop3 Improve Skeletal and Muscle Properties Without Adverse Cardiovascular Effects in Orchiectomized Mice

Novel Aptamers Targeting Sclerostin Loop3 Improve Skeletal and Muscle Properties Without Adverse Cardiovascular Effects in Orchiectomized Mice

ABSTRACT Background The Wnt/β‐catenin pathway and its bone‐specific inhibitor, sclerostin, play important roles in skeletal development and homeostasis. The humanized sclerostin antibody, romosozumab, can significantly increase bone mineral density (BMD) of patients with osteoporosis, but it may als...

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Bibliographic Details
Main Authors: Bingna Zhou, Jing Hu, Yuanyuan Yu, Lei Sun, Yanye Wang, Qian Zhang, Yan Jiang, Ou Wang, Xiaoping Xing, Weibo Xia, Luyao Wang, Ge Zhang, Mei Li
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
adverse cardiovascular effects
aptamers
male osteoporosis
sarcopenia
sclerostin loop3
Online Access:https://doi.org/10.1002/jcsm.13831
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