Research progress of DNA methylation in the screening of cervical cancer and precancerous lesions
Abstract Cervical cancer is one of the most common malignant tumors that seriously threaten women's health. Persistent infection with high risk human papillomavirus (HPV) is closely related to the progression of cervical cancer. Cervical cancer screening is an effective measure to reduce the in...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-01-01
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| Series: | Interdisciplinary Medicine |
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| Online Access: | https://doi.org/10.1002/INMD.20240043 |
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| author | Yunge Wang Xueping Ma Tao Zhang Lingfei Wang Yunlong Liu Guohua Zhou Haiping Wu |
| author_facet | Yunge Wang Xueping Ma Tao Zhang Lingfei Wang Yunlong Liu Guohua Zhou Haiping Wu |
| author_sort | Yunge Wang |
| collection | DOAJ |
| description | Abstract Cervical cancer is one of the most common malignant tumors that seriously threaten women's health. Persistent infection with high risk human papillomavirus (HPV) is closely related to the progression of cervical cancer. Cervical cancer screening is an effective measure to reduce the incidence and mortality of cervical cancer. The two most common screening strategies are cytology and HPV testing, but they easily lead to missed diagnosis or overdiagnosis. To overcome such limitations, a new triage method needs to be explored. The World Health Organization second edition guideline includes DNA methylation testing as a new method to be evaluated. DNA methylation is a common epigenetic modification and is considered to be closely related to the occurrence and development of tumors. In recent years, many methylated genes have been found to be biomarkers for cervical cancer and precancerous lesions diagnosis. In this paper, we focus on the role and application of host DNA methylation, HPV DNA methylation, as well as combined host and HPV DNA methylation in the screening of cervical cancer and precancerous lesions. |
| format | Article |
| id | doaj-art-a456f308fe3945828cecaa0d64134816 |
| institution | Kabale University |
| issn | 2832-6245 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Interdisciplinary Medicine |
| spelling | doaj-art-a456f308fe3945828cecaa0d641348162025-01-25T17:57:32ZengWiley-VCHInterdisciplinary Medicine2832-62452025-01-0131n/an/a10.1002/INMD.20240043Research progress of DNA methylation in the screening of cervical cancer and precancerous lesionsYunge Wang0Xueping Ma1Tao Zhang2Lingfei Wang3Yunlong Liu4Guohua Zhou5Haiping Wu6Department of Clinical Pharmacy Jinling Hospital School of Pharmaceutical Sciences Southern Medical University Guangzhou Guangdong ChinaDepartment of Clinical Pharmacy Jinling Hospital School of Pharmaceutical Sciences Southern Medical University Guangzhou Guangdong ChinaDepartment of Clinical Pharmacy Jinling Hospital School of Pharmaceutical Sciences Southern Medical University Guangzhou Guangdong ChinaDepartment of Clinical Pharmacy Jinling Hospital School of Pharmaceutical Sciences Southern Medical University Guangzhou Guangdong ChinaDepartment of Biomedical Engineering School of Engineering China Pharmaceutical University Nanjing Jiangsu ChinaDepartment of Clinical Pharmacy Jinling Hospital Affiliated Hospital of Medical School State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine Nanjing University Nanjing Jiangsu ChinaDepartment of Clinical Pharmacy Jinling Hospital School of Pharmaceutical Sciences Southern Medical University Guangzhou Guangdong ChinaAbstract Cervical cancer is one of the most common malignant tumors that seriously threaten women's health. Persistent infection with high risk human papillomavirus (HPV) is closely related to the progression of cervical cancer. Cervical cancer screening is an effective measure to reduce the incidence and mortality of cervical cancer. The two most common screening strategies are cytology and HPV testing, but they easily lead to missed diagnosis or overdiagnosis. To overcome such limitations, a new triage method needs to be explored. The World Health Organization second edition guideline includes DNA methylation testing as a new method to be evaluated. DNA methylation is a common epigenetic modification and is considered to be closely related to the occurrence and development of tumors. In recent years, many methylated genes have been found to be biomarkers for cervical cancer and precancerous lesions diagnosis. In this paper, we focus on the role and application of host DNA methylation, HPV DNA methylation, as well as combined host and HPV DNA methylation in the screening of cervical cancer and precancerous lesions.https://doi.org/10.1002/INMD.20240043biological markercervix neoplasmsDNA methylationhuman papillomavirusreview |
| spellingShingle | Yunge Wang Xueping Ma Tao Zhang Lingfei Wang Yunlong Liu Guohua Zhou Haiping Wu Research progress of DNA methylation in the screening of cervical cancer and precancerous lesions Interdisciplinary Medicine biological marker cervix neoplasms DNA methylation human papillomavirus review |
| title | Research progress of DNA methylation in the screening of cervical cancer and precancerous lesions |
| title_full | Research progress of DNA methylation in the screening of cervical cancer and precancerous lesions |
| title_fullStr | Research progress of DNA methylation in the screening of cervical cancer and precancerous lesions |
| title_full_unstemmed | Research progress of DNA methylation in the screening of cervical cancer and precancerous lesions |
| title_short | Research progress of DNA methylation in the screening of cervical cancer and precancerous lesions |
| title_sort | research progress of dna methylation in the screening of cervical cancer and precancerous lesions |
| topic | biological marker cervix neoplasms DNA methylation human papillomavirus review |
| url | https://doi.org/10.1002/INMD.20240043 |
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