Intraocular Lens Opacification following Intracameral Injection of Recombinant Tissue Plasminogen Activator to Treat Inflammatory Membranes after Cataract Surgery
Purpose. To report 7 cases of intraocular lens (IOL) opacification following treatment of postoperative anterior chamber fibrin with recombinant tissue plasminogen activator (rtPA) after cataract surgery. Methods. Retrospective case series of 7 eyes in 7 patients who developed IOL opacification afte...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/975075 |
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| author | Simon S. M. Fung Evripidis Sykakis Niaz M. Islam Hadi J. Zambarakji Ramin Khoramnia Gerd U. Auffarth Dipak N. Parmar |
| author_facet | Simon S. M. Fung Evripidis Sykakis Niaz M. Islam Hadi J. Zambarakji Ramin Khoramnia Gerd U. Auffarth Dipak N. Parmar |
| author_sort | Simon S. M. Fung |
| collection | DOAJ |
| description | Purpose. To report 7 cases of intraocular lens (IOL) opacification following treatment of postoperative anterior chamber fibrin with recombinant tissue plasminogen activator (rtPA) after cataract surgery. Methods. Retrospective case series of 7 eyes in 7 patients who developed IOL opacification after receiving rtPA for anterior chamber inflammatory membrane formation resulting from phacoemulsification cataract surgery. Three explanted IOLs were investigated with light microscopy, histochemical analysis, scanning electron microscopy, and X-ray spectrometry. Results. All patients underwent uncomplicated cataract surgery and posterior chamber hydrophilic IOL implantation. Anterior chamber inflammatory membranes developed between 1 and 4 weeks of surgery and were treated with intracameral rtPA. IOL opacification was noted between 4 weeks and 6 years after rtPA treatment with reduced visual acuity, and IOL exchange was carried out in 3 patients. Light microscopy evaluation revealed diffuse fine granular deposits on the anterior surface/subsurface of IOL optic that stained positive for calcium salts. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectrometry (EDS) confirmed the presence of calcium and phosphate on the IOL. Conclusions. Intracameral rtPA, though rapidly effective in the treatment of anterior chamber inflammatory membranes following cataract surgery, may be associated with IOL opacification. |
| format | Article |
| id | doaj-art-a4567b2212ca45aaa18261b1cf915f54 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-a4567b2212ca45aaa18261b1cf915f542025-02-03T06:14:16ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/975075975075Intraocular Lens Opacification following Intracameral Injection of Recombinant Tissue Plasminogen Activator to Treat Inflammatory Membranes after Cataract SurgerySimon S. M. Fung0Evripidis Sykakis1Niaz M. Islam2Hadi J. Zambarakji3Ramin Khoramnia4Gerd U. Auffarth5Dipak N. Parmar6Department of Ophthalmology, Whipps Cross University Hospital, London E11 1NR, UKDepartment of Ophthalmology, Whipps Cross University Hospital, London E11 1NR, UKDepartment of Ophthalmology, Queen’s Hospital, Essex RM7 0AG, UKDepartment of Ophthalmology, Whipps Cross University Hospital, London E11 1NR, UKDavid J Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre (IVCRC), Department of Ophthalmology, University Hospital of Heidelberg, GermanyDavid J Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre (IVCRC), Department of Ophthalmology, University Hospital of Heidelberg, GermanyDepartment of Ophthalmology, Whipps Cross University Hospital, London E11 1NR, UKPurpose. To report 7 cases of intraocular lens (IOL) opacification following treatment of postoperative anterior chamber fibrin with recombinant tissue plasminogen activator (rtPA) after cataract surgery. Methods. Retrospective case series of 7 eyes in 7 patients who developed IOL opacification after receiving rtPA for anterior chamber inflammatory membrane formation resulting from phacoemulsification cataract surgery. Three explanted IOLs were investigated with light microscopy, histochemical analysis, scanning electron microscopy, and X-ray spectrometry. Results. All patients underwent uncomplicated cataract surgery and posterior chamber hydrophilic IOL implantation. Anterior chamber inflammatory membranes developed between 1 and 4 weeks of surgery and were treated with intracameral rtPA. IOL opacification was noted between 4 weeks and 6 years after rtPA treatment with reduced visual acuity, and IOL exchange was carried out in 3 patients. Light microscopy evaluation revealed diffuse fine granular deposits on the anterior surface/subsurface of IOL optic that stained positive for calcium salts. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectrometry (EDS) confirmed the presence of calcium and phosphate on the IOL. Conclusions. Intracameral rtPA, though rapidly effective in the treatment of anterior chamber inflammatory membranes following cataract surgery, may be associated with IOL opacification.http://dx.doi.org/10.1155/2015/975075 |
| spellingShingle | Simon S. M. Fung Evripidis Sykakis Niaz M. Islam Hadi J. Zambarakji Ramin Khoramnia Gerd U. Auffarth Dipak N. Parmar Intraocular Lens Opacification following Intracameral Injection of Recombinant Tissue Plasminogen Activator to Treat Inflammatory Membranes after Cataract Surgery Journal of Ophthalmology |
| title | Intraocular Lens Opacification following Intracameral Injection of Recombinant Tissue Plasminogen Activator to Treat Inflammatory Membranes after Cataract Surgery |
| title_full | Intraocular Lens Opacification following Intracameral Injection of Recombinant Tissue Plasminogen Activator to Treat Inflammatory Membranes after Cataract Surgery |
| title_fullStr | Intraocular Lens Opacification following Intracameral Injection of Recombinant Tissue Plasminogen Activator to Treat Inflammatory Membranes after Cataract Surgery |
| title_full_unstemmed | Intraocular Lens Opacification following Intracameral Injection of Recombinant Tissue Plasminogen Activator to Treat Inflammatory Membranes after Cataract Surgery |
| title_short | Intraocular Lens Opacification following Intracameral Injection of Recombinant Tissue Plasminogen Activator to Treat Inflammatory Membranes after Cataract Surgery |
| title_sort | intraocular lens opacification following intracameral injection of recombinant tissue plasminogen activator to treat inflammatory membranes after cataract surgery |
| url | http://dx.doi.org/10.1155/2015/975075 |
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