Effects of a 24-week yoga intervention on choriocapillaris density in Parkinson’s disease
Introduction: Parkinson’s disease (PD) involves systemic microvascular dysfunction, with choriocapillaris density (CCD) potentially reflecting it. This study examined whether a 24-week yoga intervention alters CCD in PD and whether responses differ by disease duration, severity, or intervention styl...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Clinical Parkinsonism & Related Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590112525000647 |
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| author | Lei Wan Andrew Hoover Giovana Rosa Gameiro Amanda Virgets Kylie J. Martinez Joseph Signorile Hong Jiang Jianhua Wang |
| author_facet | Lei Wan Andrew Hoover Giovana Rosa Gameiro Amanda Virgets Kylie J. Martinez Joseph Signorile Hong Jiang Jianhua Wang |
| author_sort | Lei Wan |
| collection | DOAJ |
| description | Introduction: Parkinson’s disease (PD) involves systemic microvascular dysfunction, with choriocapillaris density (CCD) potentially reflecting it. This study examined whether a 24-week yoga intervention alters CCD in PD and whether responses differ by disease duration, severity, or intervention style. Methods: Fifteen PD patients completed a supervised 24-week yoga program involving two Hatha-based styles. CCD was measured using 3 × 3 mm macular optical coherence tomography angiography (OCTA) centered on 2.5-mm foveal region. Clinical assessments included disease duration, Hoehn and Yahr (H&Y) stage, and Montreal Cognitive Assessment (MoCA), conducted at baseline and after intervention. Correlation, stratified, and subgroup analyses were performed. Results: No significant change in CCD was observed at the group level (62.9 % ± 3.9 % vs. 62.9 % ± 3.2 %; P > 0.05). Baseline CCD was inversely correlated with disease duration and H&Y stage (ρ = −0.71, P = 0.003). Patients with shorter disease duration (<5 years) or early-stage PD (H&Y stage 1) showed significant CCD reductions (ΔCCD = −4.7 %, P = 0.003; ΔCCD = −4.3 %, P = 0.002), whereas those with longer duration or advanced stage (H&Y 2–3) exhibited mild increases (ΔCCD = +2.3 %, ΔCCD = +2.8 %). Baseline CCD was inversely correlated with ΔCCD (ρ = −0.77, P < 0.001). CCD did not differ between the YogaCue and Hatha Yoga groups at baseline, follow-up, or in ΔCCD (P > 0.05). Conclusions: These findings provide preliminary evidence that CCD responses to yoga vary with disease stage but not intervention style, suggesting a potential role for CCD as a vascular marker to inform individualized rehabilitation in PD. |
| format | Article |
| id | doaj-art-a45038c4080d489bbef464a45ef653cf |
| institution | OA Journals |
| issn | 2590-1125 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Parkinsonism & Related Disorders |
| spelling | doaj-art-a45038c4080d489bbef464a45ef653cf2025-08-20T02:22:01ZengElsevierClinical Parkinsonism & Related Disorders2590-11252025-01-011310036010.1016/j.prdoa.2025.100360Effects of a 24-week yoga intervention on choriocapillaris density in Parkinson’s diseaseLei Wan0Andrew Hoover1Giovana Rosa Gameiro2Amanda Virgets3Kylie J. Martinez4Joseph Signorile5Hong Jiang6Jianhua Wang7Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, ChinaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Duke University School of Medicine, 40 Duke Medicine Circle, 124 Davison Building, Durham, NC, USADepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USADepartment of Kinesiology and Sports Sciences, University of Miami, Miami, FL, USADepartment of Kinesiology and Sports Sciences, University of Miami, Miami, FL, USADepartment of Kinesiology and Sports Sciences, University of Miami, Miami, FL, USADepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USADepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Corresponding author.Introduction: Parkinson’s disease (PD) involves systemic microvascular dysfunction, with choriocapillaris density (CCD) potentially reflecting it. This study examined whether a 24-week yoga intervention alters CCD in PD and whether responses differ by disease duration, severity, or intervention style. Methods: Fifteen PD patients completed a supervised 24-week yoga program involving two Hatha-based styles. CCD was measured using 3 × 3 mm macular optical coherence tomography angiography (OCTA) centered on 2.5-mm foveal region. Clinical assessments included disease duration, Hoehn and Yahr (H&Y) stage, and Montreal Cognitive Assessment (MoCA), conducted at baseline and after intervention. Correlation, stratified, and subgroup analyses were performed. Results: No significant change in CCD was observed at the group level (62.9 % ± 3.9 % vs. 62.9 % ± 3.2 %; P > 0.05). Baseline CCD was inversely correlated with disease duration and H&Y stage (ρ = −0.71, P = 0.003). Patients with shorter disease duration (<5 years) or early-stage PD (H&Y stage 1) showed significant CCD reductions (ΔCCD = −4.7 %, P = 0.003; ΔCCD = −4.3 %, P = 0.002), whereas those with longer duration or advanced stage (H&Y 2–3) exhibited mild increases (ΔCCD = +2.3 %, ΔCCD = +2.8 %). Baseline CCD was inversely correlated with ΔCCD (ρ = −0.77, P < 0.001). CCD did not differ between the YogaCue and Hatha Yoga groups at baseline, follow-up, or in ΔCCD (P > 0.05). Conclusions: These findings provide preliminary evidence that CCD responses to yoga vary with disease stage but not intervention style, suggesting a potential role for CCD as a vascular marker to inform individualized rehabilitation in PD.http://www.sciencedirect.com/science/article/pii/S2590112525000647Parkinson’s diseaseChoriocapillaris densityYoga interventionDisease durationHoehn and Yahr stage |
| spellingShingle | Lei Wan Andrew Hoover Giovana Rosa Gameiro Amanda Virgets Kylie J. Martinez Joseph Signorile Hong Jiang Jianhua Wang Effects of a 24-week yoga intervention on choriocapillaris density in Parkinson’s disease Clinical Parkinsonism & Related Disorders Parkinson’s disease Choriocapillaris density Yoga intervention Disease duration Hoehn and Yahr stage |
| title | Effects of a 24-week yoga intervention on choriocapillaris density in Parkinson’s disease |
| title_full | Effects of a 24-week yoga intervention on choriocapillaris density in Parkinson’s disease |
| title_fullStr | Effects of a 24-week yoga intervention on choriocapillaris density in Parkinson’s disease |
| title_full_unstemmed | Effects of a 24-week yoga intervention on choriocapillaris density in Parkinson’s disease |
| title_short | Effects of a 24-week yoga intervention on choriocapillaris density in Parkinson’s disease |
| title_sort | effects of a 24 week yoga intervention on choriocapillaris density in parkinson s disease |
| topic | Parkinson’s disease Choriocapillaris density Yoga intervention Disease duration Hoehn and Yahr stage |
| url | http://www.sciencedirect.com/science/article/pii/S2590112525000647 |
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