Integrated omics identifies molecular networks of brain-body interactions of brain injury
Summary: The molecular mechanisms of brain-body interactions in the progression of brain diseases remain unknown. Through integrative analysis of multi-organ proteomic, metabolomic, and transcriptomic data following ischemic stroke, we identified dynamic molecular signatures across organs. The heart...
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| Language: | English |
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Elsevier
2025-08-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225013641 |
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| author | Yuan-Hong Deng Hong Wang Jia-Hang Zhang Yu-Fei Wang Meng-Yao Wang Xin-Ru Pan Yao-Dan Zhang Yuan-Hui Gan Yi He Fang Xie Xiao-Shuang Feng Jia-Xin Xie Bai-Tong Liu Jiang-Tao Wang Xin-Xiao Zhang Peng-Fei Wang Jie Li Shu-Guang Yu Qing-Wu Yang Ming-Ze Bai Yong Tang Xiao-Yi Xiong |
| author_facet | Yuan-Hong Deng Hong Wang Jia-Hang Zhang Yu-Fei Wang Meng-Yao Wang Xin-Ru Pan Yao-Dan Zhang Yuan-Hui Gan Yi He Fang Xie Xiao-Shuang Feng Jia-Xin Xie Bai-Tong Liu Jiang-Tao Wang Xin-Xiao Zhang Peng-Fei Wang Jie Li Shu-Guang Yu Qing-Wu Yang Ming-Ze Bai Yong Tang Xiao-Yi Xiong |
| author_sort | Yuan-Hong Deng |
| collection | DOAJ |
| description | Summary: The molecular mechanisms of brain-body interactions in the progression of brain diseases remain unknown. Through integrative analysis of multi-organ proteomic, metabolomic, and transcriptomic data following ischemic stroke, we identified dynamic molecular signatures across organs. The heart exhibited the highest number of differentially expressed proteins (DEPs), followed by spleen and intestine. Ten DEPs were shared among three organs post-stroke, with eight in heart, six in spleen, and five in intestine. Notably, organs displayed accelerated biological aging, particularly the intestine, which is implicated in neurobehavioral regulation. Conjoint analysis further confirmed that DEPs originated from both intrinsic and immune cells that systemically infiltrated multiple organs. Finally, plasma DEPs showed high correlations with corresponding protein levels in distinct organs, potentially resulting in the systemic circulation of stroke. Our findings provide a comprehensive atlas of stroke-induced multi-organ molecular remodeling and establish a foundational framework for developing systemic therapeutic strategies targeting brain-body interactions in brain injury. |
| format | Article |
| id | doaj-art-a44fcc6a13f5492c9b3805f67b04e1b8 |
| institution | DOAJ |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-a44fcc6a13f5492c9b3805f67b04e1b82025-08-20T03:08:56ZengElsevieriScience2589-00422025-08-0128811310310.1016/j.isci.2025.113103Integrated omics identifies molecular networks of brain-body interactions of brain injuryYuan-Hong Deng0Hong Wang1Jia-Hang Zhang2Yu-Fei Wang3Meng-Yao Wang4Xin-Ru Pan5Yao-Dan Zhang6Yuan-Hui Gan7Yi He8Fang Xie9Xiao-Shuang Feng10Jia-Xin Xie11Bai-Tong Liu12Jiang-Tao Wang13Xin-Xiao Zhang14Peng-Fei Wang15Jie Li16Shu-Guang Yu17Qing-Wu Yang18Ming-Ze Bai19Yong Tang20Xiao-Yi Xiong21School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, ChinaChongqing Key Laboratory of Big Data for Bio Intelligence, Chongqing University of Posts and Telecommunications, 2 Chongwen Road, Chongqing 400065, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, ChinaSchool of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, ChinaDepartment of Neurology, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai, ChinaDepartment of Neurology, Deyang People’s Hospital, Sichuan Clinical Research Center for Neurological Diseases, Chengdu University of Traditional Chinese Medicine, Deyang, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, China; Acupuncture & Chronobiology Key Laboratory of Sichuan Province, Chengdu 610075, China; Key Laboratory of Acupuncture for Senile Disease (Chengdu University of TCM), Ministry of Education, Chengdu 610075, ChinaDepartment of Neurology, Xinqiao Hospital, the Army Medical University (Third Military Medical University), Chongqing, ChinaChongqing Key Laboratory of Big Data for Bio Intelligence, Chongqing University of Posts and Telecommunications, 2 Chongwen Road, Chongqing 400065, China; Corresponding authorSchool of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, China; Acupuncture & Chronobiology Key Laboratory of Sichuan Province, Chengdu 610075, China; International Joint Research Centre on Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China; Corresponding authorAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Road, Chengdu 611137, China; Acupuncture & Chronobiology Key Laboratory of Sichuan Province, Chengdu 610075, China; Key Laboratory of Acupuncture for Senile Disease (Chengdu University of TCM), Ministry of Education, Chengdu 610075, China; Corresponding authorSummary: The molecular mechanisms of brain-body interactions in the progression of brain diseases remain unknown. Through integrative analysis of multi-organ proteomic, metabolomic, and transcriptomic data following ischemic stroke, we identified dynamic molecular signatures across organs. The heart exhibited the highest number of differentially expressed proteins (DEPs), followed by spleen and intestine. Ten DEPs were shared among three organs post-stroke, with eight in heart, six in spleen, and five in intestine. Notably, organs displayed accelerated biological aging, particularly the intestine, which is implicated in neurobehavioral regulation. Conjoint analysis further confirmed that DEPs originated from both intrinsic and immune cells that systemically infiltrated multiple organs. Finally, plasma DEPs showed high correlations with corresponding protein levels in distinct organs, potentially resulting in the systemic circulation of stroke. Our findings provide a comprehensive atlas of stroke-induced multi-organ molecular remodeling and establish a foundational framework for developing systemic therapeutic strategies targeting brain-body interactions in brain injury.http://www.sciencedirect.com/science/article/pii/S2589004225013641neuroscienceimmunologyomics |
| spellingShingle | Yuan-Hong Deng Hong Wang Jia-Hang Zhang Yu-Fei Wang Meng-Yao Wang Xin-Ru Pan Yao-Dan Zhang Yuan-Hui Gan Yi He Fang Xie Xiao-Shuang Feng Jia-Xin Xie Bai-Tong Liu Jiang-Tao Wang Xin-Xiao Zhang Peng-Fei Wang Jie Li Shu-Guang Yu Qing-Wu Yang Ming-Ze Bai Yong Tang Xiao-Yi Xiong Integrated omics identifies molecular networks of brain-body interactions of brain injury iScience neuroscience immunology omics |
| title | Integrated omics identifies molecular networks of brain-body interactions of brain injury |
| title_full | Integrated omics identifies molecular networks of brain-body interactions of brain injury |
| title_fullStr | Integrated omics identifies molecular networks of brain-body interactions of brain injury |
| title_full_unstemmed | Integrated omics identifies molecular networks of brain-body interactions of brain injury |
| title_short | Integrated omics identifies molecular networks of brain-body interactions of brain injury |
| title_sort | integrated omics identifies molecular networks of brain body interactions of brain injury |
| topic | neuroscience immunology omics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225013641 |
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