A case of primary nonleukemic myeloid sarcoma of the spleen, successfully treated by surgery and hematopoietic stem cell transplantation
Abstract Background Myeloid sarcoma (MS) is a rare disease, mostly found in conjunction with acute myelogenous leukemia or other diseases, and primary nonleukemic MS of the spleen is particularly rare. Case presentation We report a 57-year-old male who presented with a spleen mass that was found inc...
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Japan Surgical Society
2021-08-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-021-01257-w |
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| author | Asuka Ono Yuki Kitano Katsunori Imai Takashi Matsumoto Shinya Endo Kenji Tokunaga Hiromitsu Hayashi Yo-Ichi Yamashita Masao Matsuoka Hideo Baba |
| author_facet | Asuka Ono Yuki Kitano Katsunori Imai Takashi Matsumoto Shinya Endo Kenji Tokunaga Hiromitsu Hayashi Yo-Ichi Yamashita Masao Matsuoka Hideo Baba |
| author_sort | Asuka Ono |
| collection | DOAJ |
| description | Abstract Background Myeloid sarcoma (MS) is a rare disease, mostly found in conjunction with acute myelogenous leukemia or other diseases, and primary nonleukemic MS of the spleen is particularly rare. Case presentation We report a 57-year-old male who presented with a spleen mass that was found incidentally, and was enlarged. As a result of various examinations, he was diagnosed with primary MS of the spleen with suspected involvement of the transverse colon, left kidney, pancreatic tail, and left diaphragm. He underwent a total splenectomy, partial pancreatectomy, partial colectomy, left nephrectomy, and left diaphragm partial resection. Histological examination revealed splenic primary MS. Bone marrow biopsy and immunophenotypic flow cytometry revealed no evidence of myeloid leukemia. He underwent umbilical cord blood transplantation, and he is currently living without a sign of recurrence at 10 months after surgery. Conclusions We experienced a very rare case of primary spleen MS that was discovered without a hematologic malignancy. Two cases of surgically resected primary splenic MS have been reported, including the present case. |
| format | Article |
| id | doaj-art-a44fa9c738b44f37a338db2d9ac46812 |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-a44fa9c738b44f37a338db2d9ac468122025-08-20T03:35:48ZengJapan Surgical SocietySurgical Case Reports2198-77932021-08-01711510.1186/s40792-021-01257-wA case of primary nonleukemic myeloid sarcoma of the spleen, successfully treated by surgery and hematopoietic stem cell transplantationAsuka Ono0Yuki Kitano1Katsunori Imai2Takashi Matsumoto3Shinya Endo4Kenji Tokunaga5Hiromitsu Hayashi6Yo-Ichi Yamashita7Masao Matsuoka8Hideo Baba9Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto UniversityDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto UniversityDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto UniversityDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto UniversityDepartments of Hematology, Rheumatology, and Infectious Disease, Graduate School of Medical Sciences, Kumamoto UniversityDepartments of Hematology, Rheumatology, and Infectious Disease, Graduate School of Medical Sciences, Kumamoto UniversityDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto UniversityDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto UniversityDepartments of Hematology, Rheumatology, and Infectious Disease, Graduate School of Medical Sciences, Kumamoto UniversityDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto UniversityAbstract Background Myeloid sarcoma (MS) is a rare disease, mostly found in conjunction with acute myelogenous leukemia or other diseases, and primary nonleukemic MS of the spleen is particularly rare. Case presentation We report a 57-year-old male who presented with a spleen mass that was found incidentally, and was enlarged. As a result of various examinations, he was diagnosed with primary MS of the spleen with suspected involvement of the transverse colon, left kidney, pancreatic tail, and left diaphragm. He underwent a total splenectomy, partial pancreatectomy, partial colectomy, left nephrectomy, and left diaphragm partial resection. Histological examination revealed splenic primary MS. Bone marrow biopsy and immunophenotypic flow cytometry revealed no evidence of myeloid leukemia. He underwent umbilical cord blood transplantation, and he is currently living without a sign of recurrence at 10 months after surgery. Conclusions We experienced a very rare case of primary spleen MS that was discovered without a hematologic malignancy. Two cases of surgically resected primary splenic MS have been reported, including the present case.https://doi.org/10.1186/s40792-021-01257-wMyeloid sarcomaSpleenSurgeryNonleukemic |
| spellingShingle | Asuka Ono Yuki Kitano Katsunori Imai Takashi Matsumoto Shinya Endo Kenji Tokunaga Hiromitsu Hayashi Yo-Ichi Yamashita Masao Matsuoka Hideo Baba A case of primary nonleukemic myeloid sarcoma of the spleen, successfully treated by surgery and hematopoietic stem cell transplantation Surgical Case Reports Myeloid sarcoma Spleen Surgery Nonleukemic |
| title | A case of primary nonleukemic myeloid sarcoma of the spleen, successfully treated by surgery and hematopoietic stem cell transplantation |
| title_full | A case of primary nonleukemic myeloid sarcoma of the spleen, successfully treated by surgery and hematopoietic stem cell transplantation |
| title_fullStr | A case of primary nonleukemic myeloid sarcoma of the spleen, successfully treated by surgery and hematopoietic stem cell transplantation |
| title_full_unstemmed | A case of primary nonleukemic myeloid sarcoma of the spleen, successfully treated by surgery and hematopoietic stem cell transplantation |
| title_short | A case of primary nonleukemic myeloid sarcoma of the spleen, successfully treated by surgery and hematopoietic stem cell transplantation |
| title_sort | case of primary nonleukemic myeloid sarcoma of the spleen successfully treated by surgery and hematopoietic stem cell transplantation |
| topic | Myeloid sarcoma Spleen Surgery Nonleukemic |
| url | https://doi.org/10.1186/s40792-021-01257-w |
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