RECURRENT BULLOUS ERYTHEMA MULTIFORME SECONDARY TO HERPES SIMPLEX INFECTION IN AN 18-YEAR-OLD MALE: A CASE STUDY.
Introduction Erythema multiforme (EM) is an acute, immune-mediated mucocutaneous disorder characterized by characteristic targetoid lesions. The bullous subtype is rare and often triggered by infections such as herpes simplex Virus (HSV). Recurrent EM is strongly associated with HSV reactivation....
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Student's Journal of Health Research
2025-03-01
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| Series: | Student's Journal of Health Research Africa |
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| Online Access: | https://sjhresearchafrica.org/index.php/public-html/article/view/1570 |
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| author | Abraham Mukalazi KATUNGI |
| author_facet | Abraham Mukalazi KATUNGI |
| author_sort | Abraham Mukalazi |
| collection | DOAJ |
| description | Introduction
Erythema multiforme (EM) is an acute, immune-mediated mucocutaneous disorder characterized by characteristic targetoid lesions. The bullous subtype is rare and often triggered by infections such as herpes simplex Virus (HSV). Recurrent EM is strongly associated with HSV reactivation.
Case Presentation
We report an 18-year-old HIV-seronegative male with recurrent bullous erythema multiforme secondary to oral HSV infection. The patient had a two-year history of recurrent blistering episodes occurring every 2-3 months. Laboratory findings confirmed high HSV-1 IgG titers. Histological examination supported the diagnosis of bullous erythema multiforme. The patient was treated successfully with oral acyclovir suppression therapy, leading to a complete resolution of symptoms with no recurrences for six months.
Conclusion
This case highlights the importance of recognizing HSV as a potential trigger for recurrent bullous erythema multiforme and the effectiveness of antiviral suppression therapy in preventing recurrences.
Recommendation
Early identification of recurrent HSV-associated erythema multiforme is crucial for timely intervention. Long-term suppressive antiviral therapy should be considered in patients with frequent recurrences. |
| format | Article |
| id | doaj-art-a448a672954f440d8ce0dd1e65e6a4c4 |
| institution | OA Journals |
| issn | 2709-9997 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Student's Journal of Health Research |
| record_format | Article |
| series | Student's Journal of Health Research Africa |
| spelling | doaj-art-a448a672954f440d8ce0dd1e65e6a4c42025-08-20T01:49:54ZengStudent's Journal of Health ResearchStudent's Journal of Health Research Africa2709-99972025-03-016317https://doi.org/10.51168/sjhrafrica.v6i3.1570RECURRENT BULLOUS ERYTHEMA MULTIFORME SECONDARY TO HERPES SIMPLEX INFECTION IN AN 18-YEAR-OLD MALE: A CASE STUDY. Abraham Mukalazi 0KATUNGI 1MBChB Dermatology Department, Mbarara University of Science and Technology P.O.BOX 1410 Mbarara, UgandaMBChB Dermatology Department, Mbarara University of Science and Technology P.O.BOX 1410 Mbarara, Uganda Introduction Erythema multiforme (EM) is an acute, immune-mediated mucocutaneous disorder characterized by characteristic targetoid lesions. The bullous subtype is rare and often triggered by infections such as herpes simplex Virus (HSV). Recurrent EM is strongly associated with HSV reactivation. Case Presentation We report an 18-year-old HIV-seronegative male with recurrent bullous erythema multiforme secondary to oral HSV infection. The patient had a two-year history of recurrent blistering episodes occurring every 2-3 months. Laboratory findings confirmed high HSV-1 IgG titers. Histological examination supported the diagnosis of bullous erythema multiforme. The patient was treated successfully with oral acyclovir suppression therapy, leading to a complete resolution of symptoms with no recurrences for six months. Conclusion This case highlights the importance of recognizing HSV as a potential trigger for recurrent bullous erythema multiforme and the effectiveness of antiviral suppression therapy in preventing recurrences. Recommendation Early identification of recurrent HSV-associated erythema multiforme is crucial for timely intervention. Long-term suppressive antiviral therapy should be considered in patients with frequent recurrences.https://sjhresearchafrica.org/index.php/public-html/article/view/1570bullous erythema multiformerecurrent erythema multiformeherpes simplex virusherpes simplex virus-associated erythema multiforme |
| spellingShingle | Abraham Mukalazi KATUNGI RECURRENT BULLOUS ERYTHEMA MULTIFORME SECONDARY TO HERPES SIMPLEX INFECTION IN AN 18-YEAR-OLD MALE: A CASE STUDY. Student's Journal of Health Research Africa bullous erythema multiforme recurrent erythema multiforme herpes simplex virus herpes simplex virus-associated erythema multiforme |
| title | RECURRENT BULLOUS ERYTHEMA MULTIFORME SECONDARY TO HERPES SIMPLEX INFECTION IN AN 18-YEAR-OLD MALE: A CASE STUDY. |
| title_full | RECURRENT BULLOUS ERYTHEMA MULTIFORME SECONDARY TO HERPES SIMPLEX INFECTION IN AN 18-YEAR-OLD MALE: A CASE STUDY. |
| title_fullStr | RECURRENT BULLOUS ERYTHEMA MULTIFORME SECONDARY TO HERPES SIMPLEX INFECTION IN AN 18-YEAR-OLD MALE: A CASE STUDY. |
| title_full_unstemmed | RECURRENT BULLOUS ERYTHEMA MULTIFORME SECONDARY TO HERPES SIMPLEX INFECTION IN AN 18-YEAR-OLD MALE: A CASE STUDY. |
| title_short | RECURRENT BULLOUS ERYTHEMA MULTIFORME SECONDARY TO HERPES SIMPLEX INFECTION IN AN 18-YEAR-OLD MALE: A CASE STUDY. |
| title_sort | recurrent bullous erythema multiforme secondary to herpes simplex infection in an 18 year old male a case study |
| topic | bullous erythema multiforme recurrent erythema multiforme herpes simplex virus herpes simplex virus-associated erythema multiforme |
| url | https://sjhresearchafrica.org/index.php/public-html/article/view/1570 |
| work_keys_str_mv | AT abrahammukalazi recurrentbullouserythemamultiformesecondarytoherpessimplexinfectioninan18yearoldmaleacasestudy AT katungi recurrentbullouserythemamultiformesecondarytoherpessimplexinfectioninan18yearoldmaleacasestudy |