Clinical diagnosis, treatment, and survival analysis of 61 cases of salivary duct carcinoma: a retrospective study
Objective This study aims to investigate the clinicopathological features, treatment modalities, and prognostic factors associated with salivary duct carcinoma (SDC). Methods A retrospective analysis was conducted on the clinicopathological data of 61 patients with SDC admitted to Shanxi Cancer Hosp...
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PeerJ Inc.
2025-07-01
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| author | Shubin Dong Mengru Li Zhiwei Zhang Bowei Feng Wei Ding Jiang Chang Feng Liu |
| author_facet | Shubin Dong Mengru Li Zhiwei Zhang Bowei Feng Wei Ding Jiang Chang Feng Liu |
| author_sort | Shubin Dong |
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| description | Objective This study aims to investigate the clinicopathological features, treatment modalities, and prognostic factors associated with salivary duct carcinoma (SDC). Methods A retrospective analysis was conducted on the clinicopathological data of 61 patients with SDC admitted to Shanxi Cancer Hospital from January 2010 to February 2024. This study focused on their demographic information, treatment regimens, clinical outcomes, and overall prognosis. Results A total of 61 patients with SDC were included in this study, of whom 45 (73.77%) had primary tumors in the parotid gland, 44 (72.13%) were in stage IV at the initial visit, 35 (57.38%) had cervical lymph node metastases, and two (3.28%) had distant metastasis at the first visit. Immunohistochemical (IHC) staining showed that 54 cases (88.52%) were positive for androgen receptor (AR), and 25 cases (40.98%) were positive for human epidermal growth factor receptor 2 (HER-2). Two patients did not undergo surgical treatment due to distant metastasis and received palliative chemoradiotherapy. Fifty-nine patients underwent radical surgery, and of these, 52 (88.14%) received postoperative adjuvant treatment, including chemoradiotherapy or radiotherapy alone. The median overall survival (OS) time was 20 months for the non-surgery group (n = 2), 79 months (95% CI [72.60–85.40]) for the surgery and chemoradiotherapy group (n = 22), 61 months (95% CI [49.11–72.90]) for the surgery and radiotherapy group (n = 30), 20 months (95% CI [13.60–26.40]) for the surgery-only group (n = 7). The median OS was significantly higher in the adjuvant treatment groups (radiotherapy or chemoradiotherapy) compared with the surgery only or non-surgery groups (P < 0.05). Conclusion SDC is a rare and highly aggressive malignancy with a poor prognosis. Surgical margins, American Joint Committee on Cancer (AJCC) stage, and treatment method were identified as adverse prognostic factors affecting the OS of patients with SDC. Radical surgery remains the primary treatment for salivary duct carcinoma while adjuvant therapy significantly reduces recurrence rates and improves survival. However, the overall prognosis remains challenging, highlighting the need for novel therapeutic strategies. |
| format | Article |
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| institution | DOAJ |
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| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-a4453f46cf8a41fc9958e4cebc2672302025-08-20T03:17:14ZengPeerJ Inc.PeerJ2167-83592025-07-0113e1962610.7717/peerj.19626Clinical diagnosis, treatment, and survival analysis of 61 cases of salivary duct carcinoma: a retrospective studyShubin Dong0Mengru Li1Zhiwei Zhang2Bowei Feng3Wei Ding4Jiang Chang5Feng Liu6Department of Head and Neck Surgery, Shanxi Provincial Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, ChinaAcademy of Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi Province, ChinaFirst Clinical Medical School, Shanxi Medical University, Taiyuan, Shanxi Province, ChinaSchool of Stomatology, Shanxi Medical University, Taiyuan, Shanxi Province, ChinaDepartment of Head and Neck Surgery, Shanxi Provincial Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, ChinaShanxi Provincial Cancer Hospital, Department of Pathology, Taiyuan, Shanxi, ChinaDepartment of Head and Neck Surgery, Shanxi Provincial Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, ChinaObjective This study aims to investigate the clinicopathological features, treatment modalities, and prognostic factors associated with salivary duct carcinoma (SDC). Methods A retrospective analysis was conducted on the clinicopathological data of 61 patients with SDC admitted to Shanxi Cancer Hospital from January 2010 to February 2024. This study focused on their demographic information, treatment regimens, clinical outcomes, and overall prognosis. Results A total of 61 patients with SDC were included in this study, of whom 45 (73.77%) had primary tumors in the parotid gland, 44 (72.13%) were in stage IV at the initial visit, 35 (57.38%) had cervical lymph node metastases, and two (3.28%) had distant metastasis at the first visit. Immunohistochemical (IHC) staining showed that 54 cases (88.52%) were positive for androgen receptor (AR), and 25 cases (40.98%) were positive for human epidermal growth factor receptor 2 (HER-2). Two patients did not undergo surgical treatment due to distant metastasis and received palliative chemoradiotherapy. Fifty-nine patients underwent radical surgery, and of these, 52 (88.14%) received postoperative adjuvant treatment, including chemoradiotherapy or radiotherapy alone. The median overall survival (OS) time was 20 months for the non-surgery group (n = 2), 79 months (95% CI [72.60–85.40]) for the surgery and chemoradiotherapy group (n = 22), 61 months (95% CI [49.11–72.90]) for the surgery and radiotherapy group (n = 30), 20 months (95% CI [13.60–26.40]) for the surgery-only group (n = 7). The median OS was significantly higher in the adjuvant treatment groups (radiotherapy or chemoradiotherapy) compared with the surgery only or non-surgery groups (P < 0.05). Conclusion SDC is a rare and highly aggressive malignancy with a poor prognosis. Surgical margins, American Joint Committee on Cancer (AJCC) stage, and treatment method were identified as adverse prognostic factors affecting the OS of patients with SDC. Radical surgery remains the primary treatment for salivary duct carcinoma while adjuvant therapy significantly reduces recurrence rates and improves survival. However, the overall prognosis remains challenging, highlighting the need for novel therapeutic strategies.https://peerj.com/articles/19626.pdfSalivary duct carcinomaSalivary gland carcinomaSurgical treatment |
| spellingShingle | Shubin Dong Mengru Li Zhiwei Zhang Bowei Feng Wei Ding Jiang Chang Feng Liu Clinical diagnosis, treatment, and survival analysis of 61 cases of salivary duct carcinoma: a retrospective study PeerJ Salivary duct carcinoma Salivary gland carcinoma Surgical treatment |
| title | Clinical diagnosis, treatment, and survival analysis of 61 cases of salivary duct carcinoma: a retrospective study |
| title_full | Clinical diagnosis, treatment, and survival analysis of 61 cases of salivary duct carcinoma: a retrospective study |
| title_fullStr | Clinical diagnosis, treatment, and survival analysis of 61 cases of salivary duct carcinoma: a retrospective study |
| title_full_unstemmed | Clinical diagnosis, treatment, and survival analysis of 61 cases of salivary duct carcinoma: a retrospective study |
| title_short | Clinical diagnosis, treatment, and survival analysis of 61 cases of salivary duct carcinoma: a retrospective study |
| title_sort | clinical diagnosis treatment and survival analysis of 61 cases of salivary duct carcinoma a retrospective study |
| topic | Salivary duct carcinoma Salivary gland carcinoma Surgical treatment |
| url | https://peerj.com/articles/19626.pdf |
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