Cell-Oriented Modeling of Angiogenesis
Due to its significant involvement in various physiological and pathological conditions, angiogenesis (the development of new blood vessels from an existing vasculature) represents an important area of the actual biological research and a field in which mathematical modeling proved particularly use...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2011/586475 |
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| _version_ | 1832548907856429056 |
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| author | Diego Guidolin Piera Rebuffat Giovanna Albertin |
| author_facet | Diego Guidolin Piera Rebuffat Giovanna Albertin |
| author_sort | Diego Guidolin |
| collection | DOAJ |
| description | Due to its significant involvement in various physiological and pathological conditions, angiogenesis (the development of new blood vessels from an existing vasculature) represents an important area of the actual biological research and a field in which mathematical modeling proved particularly useful in supporting the experimental work. In this paper, we focus on a specific modeling strategy, known as “cell-centered” approach. This type of mathematical models work at a “mesoscopic scale,” assuming the cell as the natural level of abstraction for computational modeling of development. They treat cells phenomenologically, considering their essential behaviors to study how tissue structure and organization emerge from the collective dynamics of multiple cells. The main contributions of the cell-oriented approach to the study of the angiogenic process will be described. From one side, they have generated “basic science understanding” about the process of capillary assembly during development, growth, and pathology. On the other side, models were also developed supporting “applied biomedical research” for the purpose of identifying new therapeutic targets and clinically relevant approaches for either inhibiting or stimulating angiogenesis. |
| format | Article |
| id | doaj-art-a439e32a880f48969d878de59553534a |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a439e32a880f48969d878de59553534a2025-02-03T06:12:40ZengWileyThe Scientific World Journal1537-744X2011-01-01111735174810.1100/2011/586475586475Cell-Oriented Modeling of AngiogenesisDiego Guidolin0Piera Rebuffat1Giovanna Albertin2Department of Human Anatomy and Physiology, University of Padova Medical School, via Gabelli 65, 35121 Padova, ItalyDepartment of Human Anatomy and Physiology, University of Padova Medical School, via Gabelli 65, 35121 Padova, ItalyDepartment of Human Anatomy and Physiology, University of Padova Medical School, via Gabelli 65, 35121 Padova, ItalyDue to its significant involvement in various physiological and pathological conditions, angiogenesis (the development of new blood vessels from an existing vasculature) represents an important area of the actual biological research and a field in which mathematical modeling proved particularly useful in supporting the experimental work. In this paper, we focus on a specific modeling strategy, known as “cell-centered” approach. This type of mathematical models work at a “mesoscopic scale,” assuming the cell as the natural level of abstraction for computational modeling of development. They treat cells phenomenologically, considering their essential behaviors to study how tissue structure and organization emerge from the collective dynamics of multiple cells. The main contributions of the cell-oriented approach to the study of the angiogenic process will be described. From one side, they have generated “basic science understanding” about the process of capillary assembly during development, growth, and pathology. On the other side, models were also developed supporting “applied biomedical research” for the purpose of identifying new therapeutic targets and clinically relevant approaches for either inhibiting or stimulating angiogenesis.http://dx.doi.org/10.1100/2011/586475 |
| spellingShingle | Diego Guidolin Piera Rebuffat Giovanna Albertin Cell-Oriented Modeling of Angiogenesis The Scientific World Journal |
| title | Cell-Oriented Modeling of Angiogenesis |
| title_full | Cell-Oriented Modeling of Angiogenesis |
| title_fullStr | Cell-Oriented Modeling of Angiogenesis |
| title_full_unstemmed | Cell-Oriented Modeling of Angiogenesis |
| title_short | Cell-Oriented Modeling of Angiogenesis |
| title_sort | cell oriented modeling of angiogenesis |
| url | http://dx.doi.org/10.1100/2011/586475 |
| work_keys_str_mv | AT diegoguidolin cellorientedmodelingofangiogenesis AT pierarebuffat cellorientedmodelingofangiogenesis AT giovannaalbertin cellorientedmodelingofangiogenesis |