Green-chemistry of by-products from Sai-Nam-Phueng orange in Thailand (1): Recovering a valuable source of bioactive compounds using response surface methodology, antioxidant, and cytotoxicity
Citrus reticulata Blanco, specifically Sai-Nam-Phueng orange traditionally considered by-products, are rich in phytochemicals — limonoids, flavonoids. This study compared seeds and peels for the phytochemical content and antioxidant activity. Using single-factor experiments and response surface meth...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Waste Management Bulletin |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949750724000889 |
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| author | Kanchanok Kodchakorn Prachya Kongtawelert |
| author_facet | Kanchanok Kodchakorn Prachya Kongtawelert |
| author_sort | Kanchanok Kodchakorn |
| collection | DOAJ |
| description | Citrus reticulata Blanco, specifically Sai-Nam-Phueng orange traditionally considered by-products, are rich in phytochemicals — limonoids, flavonoids. This study compared seeds and peels for the phytochemical content and antioxidant activity. Using single-factor experiments and response surface methodology (RSM), the effects of ethanol concentration, solvent-to-solid ratio, and temperature on extract yield were optimized. The study found optimal conditions to be 70.50 % ethanol, 28.11 mL/g solvent-to-solid ratio, and 69.99 °C. Experimental values are in reasonable agreement with predicted values. Phytochemical contents were characterized using HPLC, mass spectrometry, and NMR spectroscopy, successfully demonstrating efficient of purified compounds from orange by-products and cost-effective extraction methods.Kewords: Antioxidant, Green-extractions, Phytochemicals, Response Surface Methodology, Cytotoxicity. |
| format | Article |
| id | doaj-art-a43909fa2d8943cca21aa1dcc91332ef |
| institution | DOAJ |
| issn | 2949-7507 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Waste Management Bulletin |
| spelling | doaj-art-a43909fa2d8943cca21aa1dcc91332ef2025-08-20T02:49:02ZengElsevierWaste Management Bulletin2949-75072024-12-012410812210.1016/j.wmb.2024.10.004Green-chemistry of by-products from Sai-Nam-Phueng orange in Thailand (1): Recovering a valuable source of bioactive compounds using response surface methodology, antioxidant, and cytotoxicityKanchanok Kodchakorn0Prachya Kongtawelert1Office of Research Administration, Chiang Mai University 50200, Thailand; Corresponding authors.Department of Biochemistry, Faculty of Medicine, Chiang Mai University 50200, Thailand; Corresponding authors.Citrus reticulata Blanco, specifically Sai-Nam-Phueng orange traditionally considered by-products, are rich in phytochemicals — limonoids, flavonoids. This study compared seeds and peels for the phytochemical content and antioxidant activity. Using single-factor experiments and response surface methodology (RSM), the effects of ethanol concentration, solvent-to-solid ratio, and temperature on extract yield were optimized. The study found optimal conditions to be 70.50 % ethanol, 28.11 mL/g solvent-to-solid ratio, and 69.99 °C. Experimental values are in reasonable agreement with predicted values. Phytochemical contents were characterized using HPLC, mass spectrometry, and NMR spectroscopy, successfully demonstrating efficient of purified compounds from orange by-products and cost-effective extraction methods.Kewords: Antioxidant, Green-extractions, Phytochemicals, Response Surface Methodology, Cytotoxicity.http://www.sciencedirect.com/science/article/pii/S2949750724000889 |
| spellingShingle | Kanchanok Kodchakorn Prachya Kongtawelert Green-chemistry of by-products from Sai-Nam-Phueng orange in Thailand (1): Recovering a valuable source of bioactive compounds using response surface methodology, antioxidant, and cytotoxicity Waste Management Bulletin |
| title | Green-chemistry of by-products from Sai-Nam-Phueng orange in Thailand (1): Recovering a valuable source of bioactive compounds using response surface methodology, antioxidant, and cytotoxicity |
| title_full | Green-chemistry of by-products from Sai-Nam-Phueng orange in Thailand (1): Recovering a valuable source of bioactive compounds using response surface methodology, antioxidant, and cytotoxicity |
| title_fullStr | Green-chemistry of by-products from Sai-Nam-Phueng orange in Thailand (1): Recovering a valuable source of bioactive compounds using response surface methodology, antioxidant, and cytotoxicity |
| title_full_unstemmed | Green-chemistry of by-products from Sai-Nam-Phueng orange in Thailand (1): Recovering a valuable source of bioactive compounds using response surface methodology, antioxidant, and cytotoxicity |
| title_short | Green-chemistry of by-products from Sai-Nam-Phueng orange in Thailand (1): Recovering a valuable source of bioactive compounds using response surface methodology, antioxidant, and cytotoxicity |
| title_sort | green chemistry of by products from sai nam phueng orange in thailand 1 recovering a valuable source of bioactive compounds using response surface methodology antioxidant and cytotoxicity |
| url | http://www.sciencedirect.com/science/article/pii/S2949750724000889 |
| work_keys_str_mv | AT kanchanokkodchakorn greenchemistryofbyproductsfromsainamphuengorangeinthailand1recoveringavaluablesourceofbioactivecompoundsusingresponsesurfacemethodologyantioxidantandcytotoxicity AT prachyakongtawelert greenchemistryofbyproductsfromsainamphuengorangeinthailand1recoveringavaluablesourceofbioactivecompoundsusingresponsesurfacemethodologyantioxidantandcytotoxicity |