Development and validation of a histological calculator for anastomotic margins to predict anastomotic failure among rectal cancer patients treated with neoadjuvant chemoradiotherapy

Development and validation of a histological calculator for anastomotic margins to predict anastomotic failure among rectal cancer patients treated with neoadjuvant chemoradiotherapy

Abstract Purpose To identify histological features of anastomotic margins and develop a prediction model for anastomotic failure (AF) in rectal cancer (RC) patients with neoadjuvant chemoradiotherapy (nCRT). Methods A total of 350 pairs anastomotic “doughnuts” from RC with nCRT were randomly divided...

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Bibliographic Details
Main Authors: Zhun Liu, Shenghui Huang, Meifang Xu, Qian Yu, Jianyuan Song, Zhifen Chen, Ying Huang, Pan Chi
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
Rectal cancer
Radiotherapy
Nomogram
Radiation-induced colorectal injury
Anastomotic failure
Online Access:https://doi.org/10.1186/s12885-025-14522-0
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