A lasting antibacterial, pro‐angiogenic, and pro‐osteogenic zirconium‐based bulk metallic glass for dental implants
Abstract Bacterial infection and mismatched mechanical properties are important factors that increase the risk of dental implant failure. However, zirconium (Zr)‐based bulk metallic glasses (BMGs) can have both high strength and low modulus, as well as good biocompatibility, due to their unique atom...
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| Language: | English |
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Wiley
2025-04-01
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| Online Access: | https://doi.org/10.1002/VIW.20240099 |
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| author | Feifei Wang Yunshu Wu Fu Zheng Yuhao Zeng Zifan Zhao Yao Huang Xu Zhang Baoan Sun Yuchun Sun |
| author_facet | Feifei Wang Yunshu Wu Fu Zheng Yuhao Zeng Zifan Zhao Yao Huang Xu Zhang Baoan Sun Yuchun Sun |
| author_sort | Feifei Wang |
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| description | Abstract Bacterial infection and mismatched mechanical properties are important factors that increase the risk of dental implant failure. However, zirconium (Zr)‐based bulk metallic glasses (BMGs) can have both high strength and low modulus, as well as good biocompatibility, due to their unique atomic arrangement structure. Based on these common characteristics, different elemental compositions can endow zirconium‐based amorphous alloys with different properties. Here, we present a Zr‐based BMG containing silver (Ag) with good amorphous process ability, exhibiting lasting antibacterial, proangiogenic, and pro‐osteogenic properties. This newly developed Zr61Cu23Al12Ti2Ag2 (at.%) BMG has higher strength and lower modulus than pure Titanium (Ti). Furthermore, it could exert antibacterial effects through both contact inhibition and metal ion sterilization. And this antibacterial property could last over 3 months. The systematically in vitro and in vivo results thus demonstrate the advantages and application potentials of Zr‐based BMG as a highly promising oral implant material for dental implantation. |
| format | Article |
| id | doaj-art-a4361c37ecc541ce99d2af0e36c07ab7 |
| institution | OA Journals |
| issn | 2688-3988 2688-268X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
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| spelling | doaj-art-a4361c37ecc541ce99d2af0e36c07ab72025-08-20T02:24:50ZengWileyView2688-39882688-268X2025-04-0162n/an/a10.1002/VIW.20240099A lasting antibacterial, pro‐angiogenic, and pro‐osteogenic zirconium‐based bulk metallic glass for dental implantsFeifei Wang0Yunshu Wu1Fu Zheng2Yuhao Zeng3Zifan Zhao4Yao Huang5Xu Zhang6Baoan Sun7Yuchun Sun8Center of Digital Dentistry, Faculty of Prosthodontics, Peking University School and Hospital of Stomatology; National Center for Stomatology; National Clinical Research Center for Oral Diseases; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices; NHC Key Laboratory of Digital Stomatology; Beijing Key Laboratory of Digital Stomatology; Key Laboratory of Digital Stomatology Chinese Academy of Medical Sciences Beijing ChinaCenter of Digital Dentistry, Faculty of Prosthodontics, Peking University School and Hospital of Stomatology; National Center for Stomatology; National Clinical Research Center for Oral Diseases; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices; NHC Key Laboratory of Digital Stomatology; Beijing Key Laboratory of Digital Stomatology; Key Laboratory of Digital Stomatology Chinese Academy of Medical Sciences Beijing ChinaNational Center for Stomatology National Clinical Research Center for Oral Diseases National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Department of Orthodontics Peking University School and Hospital of Stomatology Beijing ChinaCenter of Digital Dentistry, Faculty of Prosthodontics, Peking University School and Hospital of Stomatology; National Center for Stomatology; National Clinical Research Center for Oral Diseases; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices; NHC Key Laboratory of Digital Stomatology; Beijing Key Laboratory of Digital Stomatology; Key Laboratory of Digital Stomatology Chinese Academy of Medical Sciences Beijing ChinaCenter of Digital Dentistry, Faculty of Prosthodontics, Peking University School and Hospital of Stomatology; National Center for Stomatology; National Clinical Research Center for Oral Diseases; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices; NHC Key Laboratory of Digital Stomatology; Beijing Key Laboratory of Digital Stomatology; Key Laboratory of Digital Stomatology Chinese Academy of Medical Sciences Beijing ChinaInstitute of Physics Chinese Academy of Sciences/Beijing National Laboratory for Condensed Matter Physics Beijing ChinaCenter of Digital Dentistry, Faculty of Prosthodontics, Peking University School and Hospital of Stomatology; National Center for Stomatology; National Clinical Research Center for Oral Diseases; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices; NHC Key Laboratory of Digital Stomatology; Beijing Key Laboratory of Digital Stomatology; Key Laboratory of Digital Stomatology Chinese Academy of Medical Sciences Beijing ChinaInstitute of Physics Chinese Academy of Sciences/Beijing National Laboratory for Condensed Matter Physics Beijing ChinaCenter of Digital Dentistry, Faculty of Prosthodontics, Peking University School and Hospital of Stomatology; National Center for Stomatology; National Clinical Research Center for Oral Diseases; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices; NHC Key Laboratory of Digital Stomatology; Beijing Key Laboratory of Digital Stomatology; Key Laboratory of Digital Stomatology Chinese Academy of Medical Sciences Beijing ChinaAbstract Bacterial infection and mismatched mechanical properties are important factors that increase the risk of dental implant failure. However, zirconium (Zr)‐based bulk metallic glasses (BMGs) can have both high strength and low modulus, as well as good biocompatibility, due to their unique atomic arrangement structure. Based on these common characteristics, different elemental compositions can endow zirconium‐based amorphous alloys with different properties. Here, we present a Zr‐based BMG containing silver (Ag) with good amorphous process ability, exhibiting lasting antibacterial, proangiogenic, and pro‐osteogenic properties. This newly developed Zr61Cu23Al12Ti2Ag2 (at.%) BMG has higher strength and lower modulus than pure Titanium (Ti). Furthermore, it could exert antibacterial effects through both contact inhibition and metal ion sterilization. And this antibacterial property could last over 3 months. The systematically in vitro and in vivo results thus demonstrate the advantages and application potentials of Zr‐based BMG as a highly promising oral implant material for dental implantation.https://doi.org/10.1002/VIW.20240099antibacterialdental implantsproangiogenesispro‐osteogenesiszirconium‐based metallic glasses |
| spellingShingle | Feifei Wang Yunshu Wu Fu Zheng Yuhao Zeng Zifan Zhao Yao Huang Xu Zhang Baoan Sun Yuchun Sun A lasting antibacterial, pro‐angiogenic, and pro‐osteogenic zirconium‐based bulk metallic glass for dental implants View antibacterial dental implants proangiogenesis pro‐osteogenesis zirconium‐based metallic glasses |
| title | A lasting antibacterial, pro‐angiogenic, and pro‐osteogenic zirconium‐based bulk metallic glass for dental implants |
| title_full | A lasting antibacterial, pro‐angiogenic, and pro‐osteogenic zirconium‐based bulk metallic glass for dental implants |
| title_fullStr | A lasting antibacterial, pro‐angiogenic, and pro‐osteogenic zirconium‐based bulk metallic glass for dental implants |
| title_full_unstemmed | A lasting antibacterial, pro‐angiogenic, and pro‐osteogenic zirconium‐based bulk metallic glass for dental implants |
| title_short | A lasting antibacterial, pro‐angiogenic, and pro‐osteogenic zirconium‐based bulk metallic glass for dental implants |
| title_sort | lasting antibacterial pro angiogenic and pro osteogenic zirconium based bulk metallic glass for dental implants |
| topic | antibacterial dental implants proangiogenesis pro‐osteogenesis zirconium‐based metallic glasses |
| url | https://doi.org/10.1002/VIW.20240099 |
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