Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice
Abstract Identifying the mechanistic targets of crosstalk between sarcopenia (SA) and mild cognitive impairment (MCI) is critical for screening high‐risk populations and exploring effective prevention and treatment strategies. In a nationwide multicenter prospective cohort study combined with an RCT...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202405222 |
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| author | Xianyun Wang Dajun Li Xiao Ying Li Weizhao Lu Huini Ding Chengyan Qi Xuan Wang Jing Shen Yafei Chi Tiantian Li Michelle M. Dunk Yu An Hongmei Huang Kang Yu Weili Xu Rong Xiao Yuandi Xi |
| author_facet | Xianyun Wang Dajun Li Xiao Ying Li Weizhao Lu Huini Ding Chengyan Qi Xuan Wang Jing Shen Yafei Chi Tiantian Li Michelle M. Dunk Yu An Hongmei Huang Kang Yu Weili Xu Rong Xiao Yuandi Xi |
| author_sort | Xianyun Wang |
| collection | DOAJ |
| description | Abstract Identifying the mechanistic targets of crosstalk between sarcopenia (SA) and mild cognitive impairment (MCI) is critical for screening high‐risk populations and exploring effective prevention and treatment strategies. In a nationwide multicenter prospective cohort study combined with an RCT study, it is found that indexes of muscle health reveal a strong predictive relationship with cognitive performance assessed using the Montreal Cognitive Assessment (MoCA). Furthermore, Random Forest models suggest that lecithin can predict both diseases. Erythrocyte lipid analysis and RCT study indicate the protective function of lecithin and the potential involvement of irisin in that process. In rodent models, phosphocholine (PC) alleviates learning and memory impairments and muscle attenuation in SAMP8 mice, while FNDC5/irisin knockdown accelerates brain and muscle damage or eliminates the protective effects of PC. Transcriptome analysis shows that PGC1α (the regulator of FNDC5) is regulated by PC treatment, and the results of knocking out PGC1α and FNDC5/irisin are consistent. Here it is found that muscle‐secreted FNDC5/irisin is a key target of “muscle‐brain” crosstalk, and lecithin may postpone the progression of MCI and SA by stimulating PGC1α‐FNDC5/irisin‐mediated cross‐protection of cognition and skeletal muscle. |
| format | Article |
| id | doaj-art-a435cc62596e4d4b8707f0e37328edbb |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-a435cc62596e4d4b8707f0e37328edbb2025-08-20T11:56:10ZengWileyAdvanced Science2198-38442025-08-011230n/an/a10.1002/advs.202405222Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 MiceXianyun Wang0Dajun Li1Xiao Ying Li2Weizhao Lu3Huini Ding4Chengyan Qi5Xuan Wang6Jing Shen7Yafei Chi8Tiantian Li9Michelle M. Dunk10Yu An11Hongmei Huang12Kang Yu13Weili Xu14Rong Xiao15Yuandi Xi16Beijing Key Laboratory of environment and aging, School of Public Health Capital Medical University Beijing 100069 ChinaBeijing Key Laboratory of environment and aging, School of Public Health Capital Medical University Beijing 100069 ChinaDepartment of Geriatrics Beijing Jishuitan Hospital Capital Medical University Beijing 102208 ChinaSchool of Radiology Shandong First Medical University & Shandong Academy of Medical Sciences Taian 271016 ChinaBeijing Key Laboratory of environment and aging, School of Public Health Capital Medical University Beijing 100069 ChinaBeijing Key Laboratory of environment and aging, School of Public Health Capital Medical University Beijing 100069 ChinaDepartment of Neurology and Department of Clinical Trial Center Beijing Tiantan Hospital Capital Medical University Beijing 100071 ChinaBeijing Key Laboratory of environment and aging, School of Public Health Capital Medical University Beijing 100069 ChinaDepartment of Experimental Animals Capital Medical University Beijing 100069 ChinaBeijing Key Laboratory of environment and aging, School of Public Health Capital Medical University Beijing 100069 ChinaAging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm 17165 SwedenMedical Research Center Beijing Institute of Respiratory Medicine and Beijing Chao‐Yang Hospital Capital Medical University Beijing 100020 ChinaDepartment of Clinical Nutrition Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 ChinaDepartment of Clinical Nutrition and Department of Health Medicine Peking Union Medical College Hospital Beijing 100730 ChinaAging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm 17165 SwedenBeijing Key Laboratory of environment and aging, School of Public Health Capital Medical University Beijing 100069 ChinaBeijing Key Laboratory of environment and aging, School of Public Health Capital Medical University Beijing 100069 ChinaAbstract Identifying the mechanistic targets of crosstalk between sarcopenia (SA) and mild cognitive impairment (MCI) is critical for screening high‐risk populations and exploring effective prevention and treatment strategies. In a nationwide multicenter prospective cohort study combined with an RCT study, it is found that indexes of muscle health reveal a strong predictive relationship with cognitive performance assessed using the Montreal Cognitive Assessment (MoCA). Furthermore, Random Forest models suggest that lecithin can predict both diseases. Erythrocyte lipid analysis and RCT study indicate the protective function of lecithin and the potential involvement of irisin in that process. In rodent models, phosphocholine (PC) alleviates learning and memory impairments and muscle attenuation in SAMP8 mice, while FNDC5/irisin knockdown accelerates brain and muscle damage or eliminates the protective effects of PC. Transcriptome analysis shows that PGC1α (the regulator of FNDC5) is regulated by PC treatment, and the results of knocking out PGC1α and FNDC5/irisin are consistent. Here it is found that muscle‐secreted FNDC5/irisin is a key target of “muscle‐brain” crosstalk, and lecithin may postpone the progression of MCI and SA by stimulating PGC1α‐FNDC5/irisin‐mediated cross‐protection of cognition and skeletal muscle.https://doi.org/10.1002/advs.202405222FNDC5irisinlecithinmild cognitive impairmentsarcopenia |
| spellingShingle | Xianyun Wang Dajun Li Xiao Ying Li Weizhao Lu Huini Ding Chengyan Qi Xuan Wang Jing Shen Yafei Chi Tiantian Li Michelle M. Dunk Yu An Hongmei Huang Kang Yu Weili Xu Rong Xiao Yuandi Xi Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice Advanced Science FNDC5 irisin lecithin mild cognitive impairment sarcopenia |
| title | Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice |
| title_full | Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice |
| title_fullStr | Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice |
| title_full_unstemmed | Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice |
| title_short | Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice |
| title_sort | lecithin alleviates memory deficits and muscle attenuation in chinese older adults and samp8 mice |
| topic | FNDC5 irisin lecithin mild cognitive impairment sarcopenia |
| url | https://doi.org/10.1002/advs.202405222 |
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