Decreased non-neurogenic acetylcholine in bone marrow triggers age-related defective stem/progenitor cell homing

Decreased non-neurogenic acetylcholine in bone marrow triggers age-related defective stem/progenitor cell homing

Abstract Age-related decline in the ability of bone marrow (BM) to recruit transplanted hematopoietic stem and progenitor cells (HSPCs) limits the potential of HSPC-based medicine. Using in vivo imaging and manipulation combined with integrative metabolomic analyses, we show that, with aging, degrad...

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Main Authors: Takayuki Morikawa, Shinya Fujita, Yuki Sugiura, Shinpei Tamaki, Miho Haraguchi, Kohei Shiroshita, Shintaro Watanuki, Hiroshi Kobayashi, Hikari Kanai-Sudo, Yoshiko Naito, Noriyo Hayakawa, Tomomi Matsuura, Takako Hishiki, Minoru Matsui, Masato Tsutsui, Makoto Suematsu, Keiyo Takubo
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60515-9
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