Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sample
The global aging population has led to a significant rise in dementia and cognitive decline, with Alzheimer's disease as the primary cause. Early detection of mild cognitive impairment (MCI), a prodromal stage of dementia, is critical for timely intervention. The Mini-Mental State Examination (...
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Elsevier
2025-06-01
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| Series: | NeuroImage: Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666956025000327 |
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| author | Yoichi Sawada Toru Satoh Hideaki Saba Yoshiki Kato Tomoko Kuwada Sayoko Shima Kana Murakami Megumi Sasaki Yudai Abe Kaori Harano |
| author_facet | Yoichi Sawada Toru Satoh Hideaki Saba Yoshiki Kato Tomoko Kuwada Sayoko Shima Kana Murakami Megumi Sasaki Yudai Abe Kaori Harano |
| author_sort | Yoichi Sawada |
| collection | DOAJ |
| description | The global aging population has led to a significant rise in dementia and cognitive decline, with Alzheimer's disease as the primary cause. Early detection of mild cognitive impairment (MCI), a prodromal stage of dementia, is critical for timely intervention. The Mini-Mental State Examination (MMSE) is commonly used for cognitive screening, yet its limitations—such as ceiling effects and educational biases—may hinder the early identification of subtle cognitive impairments. This cross-sectional study employed voxel-based morphometry (VBM) analysis of structural magnetic resonance imaging (MRI) to explore brain regions positively correlated with MMSE scores in a cohort of 510 participants. Significant gray matter volume (GMV) reductions were observed in the bilateral lateral frontal lobes, left medial frontal lobe, left hippocampus, left anterior cingulate cortex (ACC), and bilateral inferior temporal gyri in association with lower MMSE scores. Participants were classified into three groups—Normal Cognition (NC), MCI, and Dementia (D)—based on MMSE cutoff values. Compared to the NC group, the MCI group exhibited significant GMV reductions in the left hippocampus, left parahippocampal gyrus, left ACC, and right ventromedial prefrontal cortex (vmPFC). The D group showed further GMV reductions in the bilateral hippocampus and left inferior temporal gyrus compared to the MCI group. These findings highlight the clinical utility of VBM-based structural MRI in assessing localized brain atrophy associated with cognitive decline, supporting its potential role in early diagnosis and intervention for MCI. Further research integrating longitudinal studies and multimodal biomarkers is warranted to enhance diagnostic accuracy. |
| format | Article |
| id | doaj-art-a43356d7a26a4d12b1657ab0d1986c97 |
| institution | OA Journals |
| issn | 2666-9560 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Reports |
| spelling | doaj-art-a43356d7a26a4d12b1657ab0d1986c972025-08-20T02:01:51ZengElsevierNeuroImage: Reports2666-95602025-06-015210026410.1016/j.ynirp.2025.100264Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sampleYoichi Sawada0Toru Satoh1Hideaki Saba2Yoshiki Kato3Tomoko Kuwada4Sayoko Shima5Kana Murakami6Megumi Sasaki7Yudai Abe8Kaori Harano9Department of Contemporary Welfare, Faculty of Health and Welfare, Okayama Prefectural University, Japan; Corresponding author. 111 Kuboki, Soja, Okayama, 719-1197, Japan.Departments of Neurosurgery, Neurology, and Psychiatry, Ryofukai Satoh Neurosurgical Hospital, JapanSection of Higher Brain Function, Department of Rehabilitation, Ryofukai Satoh Neurosurgical Hospital, JapanSection of Higher Brain Function, Department of Rehabilitation, Ryofukai Satoh Neurosurgical Hospital, JapanSection of Higher Brain Function, Department of Rehabilitation, Ryofukai Satoh Neurosurgical Hospital, JapanSection of Higher Brain Function, Department of Rehabilitation, Ryofukai Satoh Neurosurgical Hospital, JapanDepartments of Neurosurgery, Neurology, and Psychiatry, Ryofukai Satoh Neurosurgical Hospital, JapanDepartments of Neurosurgery, Neurology, and Psychiatry, Ryofukai Satoh Neurosurgical Hospital, JapanDepartments of Neurosurgery, Neurology, and Psychiatry, Ryofukai Satoh Neurosurgical Hospital, JapanDepartment of Human Welfare, Faculty of Human Relations, Otsuma Women's University, JapanThe global aging population has led to a significant rise in dementia and cognitive decline, with Alzheimer's disease as the primary cause. Early detection of mild cognitive impairment (MCI), a prodromal stage of dementia, is critical for timely intervention. The Mini-Mental State Examination (MMSE) is commonly used for cognitive screening, yet its limitations—such as ceiling effects and educational biases—may hinder the early identification of subtle cognitive impairments. This cross-sectional study employed voxel-based morphometry (VBM) analysis of structural magnetic resonance imaging (MRI) to explore brain regions positively correlated with MMSE scores in a cohort of 510 participants. Significant gray matter volume (GMV) reductions were observed in the bilateral lateral frontal lobes, left medial frontal lobe, left hippocampus, left anterior cingulate cortex (ACC), and bilateral inferior temporal gyri in association with lower MMSE scores. Participants were classified into three groups—Normal Cognition (NC), MCI, and Dementia (D)—based on MMSE cutoff values. Compared to the NC group, the MCI group exhibited significant GMV reductions in the left hippocampus, left parahippocampal gyrus, left ACC, and right ventromedial prefrontal cortex (vmPFC). The D group showed further GMV reductions in the bilateral hippocampus and left inferior temporal gyrus compared to the MCI group. These findings highlight the clinical utility of VBM-based structural MRI in assessing localized brain atrophy associated with cognitive decline, supporting its potential role in early diagnosis and intervention for MCI. Further research integrating longitudinal studies and multimodal biomarkers is warranted to enhance diagnostic accuracy.http://www.sciencedirect.com/science/article/pii/S2666956025000327DementiaGray matter volumeMild cognitive impairmentMini-mental state examinationNormal cognitionStructural magnetic resonance image |
| spellingShingle | Yoichi Sawada Toru Satoh Hideaki Saba Yoshiki Kato Tomoko Kuwada Sayoko Shima Kana Murakami Megumi Sasaki Yudai Abe Kaori Harano Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sample NeuroImage: Reports Dementia Gray matter volume Mild cognitive impairment Mini-mental state examination Normal cognition Structural magnetic resonance image |
| title | Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sample |
| title_full | Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sample |
| title_fullStr | Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sample |
| title_full_unstemmed | Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sample |
| title_short | Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sample |
| title_sort | assessment of localized brain regions correlated with mmse using vbm analysis of structural mri in a japanese sample |
| topic | Dementia Gray matter volume Mild cognitive impairment Mini-mental state examination Normal cognition Structural magnetic resonance image |
| url | http://www.sciencedirect.com/science/article/pii/S2666956025000327 |
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