Histological evaluation of platelet rich plasma and hydroxiapatite in apexogenesis: Study on experimental animals
Background/Aim. There are very few data about the effects of endogenous growth factors in vital pulp therapy, and still they are often controversial. The aim of the study was to evaluate the effects of platelet rich plasma (PRP) in conjugation with hydroxyapatite (HAP), as pulp capping materials, to...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2008-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2008/0042-84500802128D.pdf |
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| _version_ | 1849398988808126464 |
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| author | Danilović Vesna Petrović Vanja Marković Dejan Aleksić Zoran |
| author_facet | Danilović Vesna Petrović Vanja Marković Dejan Aleksić Zoran |
| author_sort | Danilović Vesna |
| collection | DOAJ |
| description | Background/Aim. There are very few data about the effects of endogenous growth factors in vital pulp therapy, and still they are often controversial. The aim of the study was to evaluate the effects of platelet rich plasma (PRP) in conjugation with hydroxyapatite (HAP), as pulp capping materials, to root and periodontium formation. Methods. Eight young monkeys (Cercopithecus Aethiops) with permanent dentition and incomplete root formation were involved in this study. After pulpotomy, the pulp lesion was capped with calcium hydroxide (control), hydroxyapatite (experimental group I) or hydroxyapatite in conjugation with PRP (experimental group II). Six months later, the animals were sacrificed, the tissue was removed en block, and prepared for the histological analysis in a routine way. Results. The results of the histological analysis revealed that healing process was characterised by dentin bridge formation, maintained morphological and functional integrity of dental pulp and complete formation of dental root and surrounding periodontium. The inflammatory reaction was scored as mild to moderate, in almost all the samples in all groups, suggesting the biocompatibility of the used materials. Conclusion. Materials used in this study are convenient as capping agents, contributing maintaining the integrity of the pulp tissue and facilitating root and periodontium formation. According to histological data it could be suggested that hydroxyapatite in conjugation with endogenous growth factors, represents superior alternative to other materials used in this study. |
| format | Article |
| id | doaj-art-a433122831cf4d059a7d4c0902fc0bfb |
| institution | Kabale University |
| issn | 0042-8450 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-a433122831cf4d059a7d4c0902fc0bfb2025-08-20T03:38:26ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502008-01-0165212813410.2298/VSP0802128DHistological evaluation of platelet rich plasma and hydroxiapatite in apexogenesis: Study on experimental animalsDanilović VesnaPetrović VanjaMarković DejanAleksić ZoranBackground/Aim. There are very few data about the effects of endogenous growth factors in vital pulp therapy, and still they are often controversial. The aim of the study was to evaluate the effects of platelet rich plasma (PRP) in conjugation with hydroxyapatite (HAP), as pulp capping materials, to root and periodontium formation. Methods. Eight young monkeys (Cercopithecus Aethiops) with permanent dentition and incomplete root formation were involved in this study. After pulpotomy, the pulp lesion was capped with calcium hydroxide (control), hydroxyapatite (experimental group I) or hydroxyapatite in conjugation with PRP (experimental group II). Six months later, the animals were sacrificed, the tissue was removed en block, and prepared for the histological analysis in a routine way. Results. The results of the histological analysis revealed that healing process was characterised by dentin bridge formation, maintained morphological and functional integrity of dental pulp and complete formation of dental root and surrounding periodontium. The inflammatory reaction was scored as mild to moderate, in almost all the samples in all groups, suggesting the biocompatibility of the used materials. Conclusion. Materials used in this study are convenient as capping agents, contributing maintaining the integrity of the pulp tissue and facilitating root and periodontium formation. According to histological data it could be suggested that hydroxyapatite in conjugation with endogenous growth factors, represents superior alternative to other materials used in this study.http://www.doiserbia.nb.rs/img/doi/0042-8450/2008/0042-84500802128D.pdftooth roothperiodontiumplatelet-rich plasmadurapatitehaplorhiniintercellular signaling peptides and proteins |
| spellingShingle | Danilović Vesna Petrović Vanja Marković Dejan Aleksić Zoran Histological evaluation of platelet rich plasma and hydroxiapatite in apexogenesis: Study on experimental animals Vojnosanitetski Pregled tooth rooth periodontium platelet-rich plasma durapatite haplorhini intercellular signaling peptides and proteins |
| title | Histological evaluation of platelet rich plasma and hydroxiapatite in apexogenesis: Study on experimental animals |
| title_full | Histological evaluation of platelet rich plasma and hydroxiapatite in apexogenesis: Study on experimental animals |
| title_fullStr | Histological evaluation of platelet rich plasma and hydroxiapatite in apexogenesis: Study on experimental animals |
| title_full_unstemmed | Histological evaluation of platelet rich plasma and hydroxiapatite in apexogenesis: Study on experimental animals |
| title_short | Histological evaluation of platelet rich plasma and hydroxiapatite in apexogenesis: Study on experimental animals |
| title_sort | histological evaluation of platelet rich plasma and hydroxiapatite in apexogenesis study on experimental animals |
| topic | tooth rooth periodontium platelet-rich plasma durapatite haplorhini intercellular signaling peptides and proteins |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2008/0042-84500802128D.pdf |
| work_keys_str_mv | AT danilovicvesna histologicalevaluationofplateletrichplasmaandhydroxiapatiteinapexogenesisstudyonexperimentalanimals AT petrovicvanja histologicalevaluationofplateletrichplasmaandhydroxiapatiteinapexogenesisstudyonexperimentalanimals AT markovicdejan histologicalevaluationofplateletrichplasmaandhydroxiapatiteinapexogenesisstudyonexperimentalanimals AT aleksiczoran histologicalevaluationofplateletrichplasmaandhydroxiapatiteinapexogenesisstudyonexperimentalanimals |