Effectiveness of Nano-hydroxyapatite-coated Implants against Peri-implantitis Bacteria
Background: Peri-implantitis, a prevalent complication of dental implants, is characterized by inflammation and bone loss caused by bacterial colonization around the implant surface. Nano-hydroxyapatite (nHA)-coated implants have shown promise in enhancing osseointegration and providing antibacteria...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_162_25 |
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| author | Ibrahim Fazal Vanshi Bangia Ashutosh Yadav Divya Batra Sunil Kar Sameer Gupta |
| author_facet | Ibrahim Fazal Vanshi Bangia Ashutosh Yadav Divya Batra Sunil Kar Sameer Gupta |
| author_sort | Ibrahim Fazal |
| collection | DOAJ |
| description | Background:
Peri-implantitis, a prevalent complication of dental implants, is characterized by inflammation and bone loss caused by bacterial colonization around the implant surface. Nano-hydroxyapatite (nHA)-coated implants have shown promise in enhancing osseointegration and providing antibacterial properties.
Materials and Methods:
A total of 40 dental implants were divided into two groups: Group A (n = 20) comprised nHA-coated implants, and Group B (n = 20) comprised uncoated titanium implants (control). The implants were incubated with Porphyromonas gingivalis, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans in vitro for 7 days. Antibacterial efficacy was assessed by quantifying colony-forming units (CFUs) using culture techniques. Additionally, biofilm formation on implant surfaces was evaluated using scanning electron microscopy (SEM).
Results:
Group A demonstrated a significant reduction in bacterial adhesion and biofilm formation compared to Group B (P < .05). The mean CFU counts for P. gingivalis, F. nucleatum, and A. actinomycetemcomitans in Group A were 1.2 × 104, 0.9 × 104, and 0.8 × 104, respectively, compared to 3.5 × 104, 2.8 × 104, and 2.4 × 104 in Group B. SEM analysis revealed a thinner biofilm layer on nHA-coated implants, indicating superior antibacterial activity.
Conclusion:
Nano-hydroxyapatite-coated implants significantly inhibit the growth of peri-implantitis-associated bacteria and reduce biofilm formation, making them a promising alternative for reducing peri-implantitis risk. Further clinical studies are warranted to validate these findings. |
| format | Article |
| id | doaj-art-a426363fa4b64b449f992ca93c8d32b0 |
| institution | DOAJ |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-a426363fa4b64b449f992ca93c8d32b02025-08-20T03:15:19ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-06-0117Suppl 2S1595S159710.4103/jpbs.jpbs_162_25Effectiveness of Nano-hydroxyapatite-coated Implants against Peri-implantitis BacteriaIbrahim FazalVanshi BangiaAshutosh YadavDivya BatraSunil KarSameer GuptaBackground: Peri-implantitis, a prevalent complication of dental implants, is characterized by inflammation and bone loss caused by bacterial colonization around the implant surface. Nano-hydroxyapatite (nHA)-coated implants have shown promise in enhancing osseointegration and providing antibacterial properties. Materials and Methods: A total of 40 dental implants were divided into two groups: Group A (n = 20) comprised nHA-coated implants, and Group B (n = 20) comprised uncoated titanium implants (control). The implants were incubated with Porphyromonas gingivalis, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans in vitro for 7 days. Antibacterial efficacy was assessed by quantifying colony-forming units (CFUs) using culture techniques. Additionally, biofilm formation on implant surfaces was evaluated using scanning electron microscopy (SEM). Results: Group A demonstrated a significant reduction in bacterial adhesion and biofilm formation compared to Group B (P < .05). The mean CFU counts for P. gingivalis, F. nucleatum, and A. actinomycetemcomitans in Group A were 1.2 × 104, 0.9 × 104, and 0.8 × 104, respectively, compared to 3.5 × 104, 2.8 × 104, and 2.4 × 104 in Group B. SEM analysis revealed a thinner biofilm layer on nHA-coated implants, indicating superior antibacterial activity. Conclusion: Nano-hydroxyapatite-coated implants significantly inhibit the growth of peri-implantitis-associated bacteria and reduce biofilm formation, making them a promising alternative for reducing peri-implantitis risk. Further clinical studies are warranted to validate these findings.https://journals.lww.com/10.4103/jpbs.jpbs_162_25antibacterial efficacybacterial adhesionbiofilmdental implantsnano-hydroxyapatiteperi-implantitis |
| spellingShingle | Ibrahim Fazal Vanshi Bangia Ashutosh Yadav Divya Batra Sunil Kar Sameer Gupta Effectiveness of Nano-hydroxyapatite-coated Implants against Peri-implantitis Bacteria Journal of Pharmacy and Bioallied Sciences antibacterial efficacy bacterial adhesion biofilm dental implants nano-hydroxyapatite peri-implantitis |
| title | Effectiveness of Nano-hydroxyapatite-coated Implants against Peri-implantitis Bacteria |
| title_full | Effectiveness of Nano-hydroxyapatite-coated Implants against Peri-implantitis Bacteria |
| title_fullStr | Effectiveness of Nano-hydroxyapatite-coated Implants against Peri-implantitis Bacteria |
| title_full_unstemmed | Effectiveness of Nano-hydroxyapatite-coated Implants against Peri-implantitis Bacteria |
| title_short | Effectiveness of Nano-hydroxyapatite-coated Implants against Peri-implantitis Bacteria |
| title_sort | effectiveness of nano hydroxyapatite coated implants against peri implantitis bacteria |
| topic | antibacterial efficacy bacterial adhesion biofilm dental implants nano-hydroxyapatite peri-implantitis |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_162_25 |
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