Modeling fire‐related smoke inhalation injury using the human lung‐on‐a‐chip and organoid platform: Pathogenesis insights and therapeutic evaluation

Modeling fire‐related smoke inhalation injury using the human lung‐on‐a‐chip and organoid platform: Pathogenesis insights and therapeutic evaluation

Abstract Fire‐related smoke inhalation‐induced acute lung injury (SI‐ALI) is a prevalent condition in modern fires, characterized by high mortality and a lack of targeted therapeutic options. Previous research has been hindered by instability in smoke generation and modeling methods, limiting the in...

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Bibliographic Details
Main Authors: Junmin Li, Dezhong Zhang, Yan Meng, Yongqing Chang, Wenbo Wei, Peng Wu, Lin Peng, Wei Chang, Wei Wang, Jie Huang, Jingjing Fang, Keming Zhu, Xiaojian Wan
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:View
Subjects:
acute lung injury
drug screening
fire incidents
molecular docking
organ‐on‐a‐chip
organoids
Online Access:https://doi.org/10.1002/VIW.20240114
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