A Case of Epithelioid Angiosarcoma Diagnosed From Gross Examination of a Pulmonary Tumor Utilizing Imprint Cytology and Immunocytochemistry
ABSTRACT Background Angiosarcoma, a very rare malignant tumor constituting 2%–4% of soft tissue sarcomas, manifest in diverse organs including skin, soft tissues, and bones. Histologically, angiosarcoma presents a wide range of morphologies, with epithelioid angiosarcoma (EAS) resemblance to carcino...
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| Format: | Article |
| Language: | English |
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Wiley
2024-10-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.70014 |
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| author | Tatsuya Mori Keishi Mizuguchi Chie Shimaguchi Kaori Sakano Tsubasa Shimoda Urara Okawa Miyu Okuda Mayo Usui Hiroko Ikeda |
| author_facet | Tatsuya Mori Keishi Mizuguchi Chie Shimaguchi Kaori Sakano Tsubasa Shimoda Urara Okawa Miyu Okuda Mayo Usui Hiroko Ikeda |
| author_sort | Tatsuya Mori |
| collection | DOAJ |
| description | ABSTRACT Background Angiosarcoma, a very rare malignant tumor constituting 2%–4% of soft tissue sarcomas, manifest in diverse organs including skin, soft tissues, and bones. Histologically, angiosarcoma presents a wide range of morphologies, with epithelioid angiosarcoma (EAS) resemblance to carcinoma. The difficulty arises from the shared epithelial‐like morphology and expression of epithelial markers in immunohistochemistry. Case This study reports a case where EAS diagnosis was achieved through a combination of gross findings in a lung resection sample, imprint cytology, and immunocytochemistry. Imprint cytology revealed clusters of epithelioid cells, while immunocytochemistry showed positive results for CD31, ERG, Fli‐1, and AE1/AE3, proving instrumental in diagnosing EAS. The described immunocytochemical protocol facilitates prompt diagnosis exclusively through cytology samples. Conclusion This report emphasizes the potential for diagnosing EAS using cytological specimens, which is especially useful in cases where obtaining tissue samples proves challenging. |
| format | Article |
| id | doaj-art-a4216be233e044ce98286a62391afe1c |
| institution | OA Journals |
| issn | 2573-8348 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj-art-a4216be233e044ce98286a62391afe1c2025-08-20T02:12:10ZengWileyCancer Reports2573-83482024-10-01710n/an/a10.1002/cnr2.70014A Case of Epithelioid Angiosarcoma Diagnosed From Gross Examination of a Pulmonary Tumor Utilizing Imprint Cytology and ImmunocytochemistryTatsuya Mori0Keishi Mizuguchi1Chie Shimaguchi2Kaori Sakano3Tsubasa Shimoda4Urara Okawa5Miyu Okuda6Mayo Usui7Hiroko Ikeda8Department of Diagnostic Pathology Kanazawa University Hospital Kanazawa JapanDepartment of Diagnostic Pathology Kanazawa University Hospital Kanazawa JapanDepartment of Diagnostic Pathology Kanazawa University Hospital Kanazawa JapanDepartment of Diagnostic Pathology Kanazawa University Hospital Kanazawa JapanDepartment of Diagnostic Pathology Kanazawa University Hospital Kanazawa JapanDepartment of Diagnostic Pathology Kanazawa University Hospital Kanazawa JapanDepartment of Diagnostic Pathology Kanazawa University Hospital Kanazawa JapanDepartment of Diagnostic Pathology Kanazawa University Hospital Kanazawa JapanDepartment of Diagnostic Pathology Kanazawa University Hospital Kanazawa JapanABSTRACT Background Angiosarcoma, a very rare malignant tumor constituting 2%–4% of soft tissue sarcomas, manifest in diverse organs including skin, soft tissues, and bones. Histologically, angiosarcoma presents a wide range of morphologies, with epithelioid angiosarcoma (EAS) resemblance to carcinoma. The difficulty arises from the shared epithelial‐like morphology and expression of epithelial markers in immunohistochemistry. Case This study reports a case where EAS diagnosis was achieved through a combination of gross findings in a lung resection sample, imprint cytology, and immunocytochemistry. Imprint cytology revealed clusters of epithelioid cells, while immunocytochemistry showed positive results for CD31, ERG, Fli‐1, and AE1/AE3, proving instrumental in diagnosing EAS. The described immunocytochemical protocol facilitates prompt diagnosis exclusively through cytology samples. Conclusion This report emphasizes the potential for diagnosing EAS using cytological specimens, which is especially useful in cases where obtaining tissue samples proves challenging.https://doi.org/10.1002/cnr2.70014angiosarcomacytopathologyepithelioidimmunocytochemistrytouch‐imprint |
| spellingShingle | Tatsuya Mori Keishi Mizuguchi Chie Shimaguchi Kaori Sakano Tsubasa Shimoda Urara Okawa Miyu Okuda Mayo Usui Hiroko Ikeda A Case of Epithelioid Angiosarcoma Diagnosed From Gross Examination of a Pulmonary Tumor Utilizing Imprint Cytology and Immunocytochemistry Cancer Reports angiosarcoma cytopathology epithelioid immunocytochemistry touch‐imprint |
| title | A Case of Epithelioid Angiosarcoma Diagnosed From Gross Examination of a Pulmonary Tumor Utilizing Imprint Cytology and Immunocytochemistry |
| title_full | A Case of Epithelioid Angiosarcoma Diagnosed From Gross Examination of a Pulmonary Tumor Utilizing Imprint Cytology and Immunocytochemistry |
| title_fullStr | A Case of Epithelioid Angiosarcoma Diagnosed From Gross Examination of a Pulmonary Tumor Utilizing Imprint Cytology and Immunocytochemistry |
| title_full_unstemmed | A Case of Epithelioid Angiosarcoma Diagnosed From Gross Examination of a Pulmonary Tumor Utilizing Imprint Cytology and Immunocytochemistry |
| title_short | A Case of Epithelioid Angiosarcoma Diagnosed From Gross Examination of a Pulmonary Tumor Utilizing Imprint Cytology and Immunocytochemistry |
| title_sort | case of epithelioid angiosarcoma diagnosed from gross examination of a pulmonary tumor utilizing imprint cytology and immunocytochemistry |
| topic | angiosarcoma cytopathology epithelioid immunocytochemistry touch‐imprint |
| url | https://doi.org/10.1002/cnr2.70014 |
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