The impact of vitamin D on atopic disorders: assessing evidence for a causal relationship
Since the beginning of COVID-19 pandemic, there has been a noticeable increase in the consumption of vitamin D. Evidence accentuates the generation of a pro-tolerogenic T helper 2 cell state with vitamin D, suppressing T helper 1 inflammatory response. T helper 2 cell polarization is characteristic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1584818/full |
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| author | Valeria Andrea Zúñiga Blanca Bazan-Perkins Blanca Bazan-Perkins |
| author_facet | Valeria Andrea Zúñiga Blanca Bazan-Perkins Blanca Bazan-Perkins |
| author_sort | Valeria Andrea Zúñiga |
| collection | DOAJ |
| description | Since the beginning of COVID-19 pandemic, there has been a noticeable increase in the consumption of vitamin D. Evidence accentuates the generation of a pro-tolerogenic T helper 2 cell state with vitamin D, suppressing T helper 1 inflammatory response. T helper 2 cell polarization is characteristic of atopy. However, although the literature on vitamin D and atopy has yielded controversial results, multiple studies have described an inverse relationship between vitamin D levels and the severity of atopy, as well as an improvement of the pathology with vitamin D supplementation. A different approach is offered in the analysis of the immunological mechanisms by which vitamin D acts in the human body, supporting its use as a promoter of homeostasis. In this sense, vitamin D promotes a balanced state through the action of regulatory T cells, controlling cytokines, both pro- and anti-inflammatory, and by reducing B cell prolif eration and differentiation, thus preventing the possible development of atopy. |
| format | Article |
| id | doaj-art-a41df69fe4824a6fa233e42a0483061d |
| institution | OA Journals |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-a41df69fe4824a6fa233e42a0483061d2025-08-20T02:11:34ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-04-011210.3389/fnut.2025.15848181584818The impact of vitamin D on atopic disorders: assessing evidence for a causal relationshipValeria Andrea Zúñiga0Blanca Bazan-Perkins1Blanca Bazan-Perkins2Instituto Tecnológico y de Estudios Superiores de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, MexicoInstituto Tecnológico y de Estudios Superiores de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, MexicoInstituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, MexicoSince the beginning of COVID-19 pandemic, there has been a noticeable increase in the consumption of vitamin D. Evidence accentuates the generation of a pro-tolerogenic T helper 2 cell state with vitamin D, suppressing T helper 1 inflammatory response. T helper 2 cell polarization is characteristic of atopy. However, although the literature on vitamin D and atopy has yielded controversial results, multiple studies have described an inverse relationship between vitamin D levels and the severity of atopy, as well as an improvement of the pathology with vitamin D supplementation. A different approach is offered in the analysis of the immunological mechanisms by which vitamin D acts in the human body, supporting its use as a promoter of homeostasis. In this sense, vitamin D promotes a balanced state through the action of regulatory T cells, controlling cytokines, both pro- and anti-inflammatory, and by reducing B cell prolif eration and differentiation, thus preventing the possible development of atopy.https://www.frontiersin.org/articles/10.3389/fnut.2025.1584818/fullatopyvitamin DT helper 2 celldendritic cellsregulatory T cells |
| spellingShingle | Valeria Andrea Zúñiga Blanca Bazan-Perkins Blanca Bazan-Perkins The impact of vitamin D on atopic disorders: assessing evidence for a causal relationship Frontiers in Nutrition atopy vitamin D T helper 2 cell dendritic cells regulatory T cells |
| title | The impact of vitamin D on atopic disorders: assessing evidence for a causal relationship |
| title_full | The impact of vitamin D on atopic disorders: assessing evidence for a causal relationship |
| title_fullStr | The impact of vitamin D on atopic disorders: assessing evidence for a causal relationship |
| title_full_unstemmed | The impact of vitamin D on atopic disorders: assessing evidence for a causal relationship |
| title_short | The impact of vitamin D on atopic disorders: assessing evidence for a causal relationship |
| title_sort | impact of vitamin d on atopic disorders assessing evidence for a causal relationship |
| topic | atopy vitamin D T helper 2 cell dendritic cells regulatory T cells |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1584818/full |
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