Lactate links exercise to synaptic protection and cognitive enhancement in Alzheimer’s disease models

Abstract Background Physical exercise is known to promote cognitive resilience in aging and Alzheimer’s disease (AD), but the underlying mechanisms remain incompletely understood. Lactate, a metabolic byproduct elevated during exercise, has recently emerged as a potential neuromodulator of brain fun...

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Bibliographic Details
Main Authors: Hao Han, Yi Wu, Ru Mi, Cijia Zhang, Fengying Guan, Xiaoyan Lu, Guangwei Zhang, Zhaojie Meng, Li Chen, Ming Zhang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Medicine
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Online Access:https://doi.org/10.1186/s12916-025-04168-x
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