Heritability of cough across two generations: the RHINESSA study
Aim Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/nonproductive). Methods The RHINESSA Generation Study (Respiratory Health In Northern...
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| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2024-08-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/10/4/00071-2024.full |
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| author | Össur Ingi Emilsson Henrik Johansson Ane Johannessen Christer Janson Andreas Palm Karl A. Franklin Anna Oudin Francisco Gómez Real Mathias Holm Thorarinn Gislason Eva Lindberg Rain Jõgi Vivi Schlünssen Francisco Javier Callejas-González Jingwen Zhang Andrei Malinovschi Cecilie Svanes Magnus Ekström |
| author_facet | Össur Ingi Emilsson Henrik Johansson Ane Johannessen Christer Janson Andreas Palm Karl A. Franklin Anna Oudin Francisco Gómez Real Mathias Holm Thorarinn Gislason Eva Lindberg Rain Jõgi Vivi Schlünssen Francisco Javier Callejas-González Jingwen Zhang Andrei Malinovschi Cecilie Svanes Magnus Ekström |
| author_sort | Össur Ingi Emilsson |
| collection | DOAJ |
| description | Aim
Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/nonproductive).
Methods
The RHINESSA Generation Study (Respiratory Health In Northern Europe, Spain and Australia) includes 7155 parents (initially aged 30–54) answering detailed questionnaires in 2000 and 2010, and 8176 offspring ≥20 years answering similar questionnaires in 2012–2019. Chronic cough was categorised as productive or nonproductive (dry) cough. Associations between parental and offspring cough were analysed using mixed-effects logistic regression, adjusting for offspring age, sex, body mass index, smoking history, education level, current asthma, rhinitis, nocturnal gastroesophageal reflux; parent sex and smoking history; centre and family.
Results
Among parents with nonproductive cough, 11% of their offspring reported nonproductive cough, compared with 7% of offspring to parents without nonproductive cough, adjusted odds ratio (aOR) 1.59 (95% confidence interval 1.20–2.10). Among parents with productive cough, 14% of their offspring reported productive cough, compared with 11% of offspring to parents without productive cough, aOR 1.34 (1.07–1.67). No associations were found between parent productive cough–offspring nonproductive cough, nor between parent nonproductive cough–offspring productive cough.
Conclusions
Parents with chronic cough are more likely to have offspring with chronic cough independent of parental asthma, suggesting cough to be a separate heritable trait. The type of cough is important, as the nonproductive cough in parent associates only with nonproductive cough in offspring, and the same applied for productive cough. |
| format | Article |
| id | doaj-art-a41b07d3ee7b4200b04a3ca30056bd0c |
| institution | OA Journals |
| issn | 2312-0541 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj-art-a41b07d3ee7b4200b04a3ca30056bd0c2025-08-20T01:54:25ZengEuropean Respiratory SocietyERJ Open Research2312-05412024-08-0110410.1183/23120541.00071-202400071-2024Heritability of cough across two generations: the RHINESSA studyÖssur Ingi Emilsson0Henrik Johansson1Ane Johannessen2Christer Janson3Andreas Palm4Karl A. Franklin5Anna Oudin6Francisco Gómez Real7Mathias Holm8Thorarinn Gislason9Eva Lindberg10Rain Jõgi11Vivi Schlünssen12Francisco Javier Callejas-González13Jingwen Zhang14Andrei Malinovschi15Cecilie Svanes16Magnus Ekström17 Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden Department of Women's and Children's Health, Physiotherapy, Uppsala University, Uppsala, Sweden Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden Department of Public Health and Clinical Medicine, Section of Sustainable Health, Umeå University, Umeå, Sweden Department of Clinical Science, University of Bergen, Bergen, Norway Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden Faculty of Medicine, University of Iceland, Reykjavik, Iceland Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden The Lung Clinic, Tartu University Hospital, Tartu, Estonia Department of Public Health, Research unit for Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark Servicio De Neumología, Complejo Hospitalario Universitario De Albacete, Albacete, Spain Allergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, Australia Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway Department of Respiratory Medicine, Allergology and Palliative Medicine, Institution for Clinical Sciences, Lund University, Lund, Sweden Aim Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/nonproductive). Methods The RHINESSA Generation Study (Respiratory Health In Northern Europe, Spain and Australia) includes 7155 parents (initially aged 30–54) answering detailed questionnaires in 2000 and 2010, and 8176 offspring ≥20 years answering similar questionnaires in 2012–2019. Chronic cough was categorised as productive or nonproductive (dry) cough. Associations between parental and offspring cough were analysed using mixed-effects logistic regression, adjusting for offspring age, sex, body mass index, smoking history, education level, current asthma, rhinitis, nocturnal gastroesophageal reflux; parent sex and smoking history; centre and family. Results Among parents with nonproductive cough, 11% of their offspring reported nonproductive cough, compared with 7% of offspring to parents without nonproductive cough, adjusted odds ratio (aOR) 1.59 (95% confidence interval 1.20–2.10). Among parents with productive cough, 14% of their offspring reported productive cough, compared with 11% of offspring to parents without productive cough, aOR 1.34 (1.07–1.67). No associations were found between parent productive cough–offspring nonproductive cough, nor between parent nonproductive cough–offspring productive cough. Conclusions Parents with chronic cough are more likely to have offspring with chronic cough independent of parental asthma, suggesting cough to be a separate heritable trait. The type of cough is important, as the nonproductive cough in parent associates only with nonproductive cough in offspring, and the same applied for productive cough.http://openres.ersjournals.com/content/10/4/00071-2024.full |
| spellingShingle | Össur Ingi Emilsson Henrik Johansson Ane Johannessen Christer Janson Andreas Palm Karl A. Franklin Anna Oudin Francisco Gómez Real Mathias Holm Thorarinn Gislason Eva Lindberg Rain Jõgi Vivi Schlünssen Francisco Javier Callejas-González Jingwen Zhang Andrei Malinovschi Cecilie Svanes Magnus Ekström Heritability of cough across two generations: the RHINESSA study ERJ Open Research |
| title | Heritability of cough across two generations: the RHINESSA study |
| title_full | Heritability of cough across two generations: the RHINESSA study |
| title_fullStr | Heritability of cough across two generations: the RHINESSA study |
| title_full_unstemmed | Heritability of cough across two generations: the RHINESSA study |
| title_short | Heritability of cough across two generations: the RHINESSA study |
| title_sort | heritability of cough across two generations the rhinessa study |
| url | http://openres.ersjournals.com/content/10/4/00071-2024.full |
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