The Proviral Reservoirs of Human Immunodeficiency Virus (HIV) Infection

Human Immunodeficiency Virus (HIV) proviral reservoirs are cells that harbor integrated HIV proviral DNA within their nuclear genomes. These cells form a heterogeneous group, represented by peripheral blood mononuclear cells (PBMCs), tissue-resident lymphoid and monocytic cells, and glial cells of t...

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Main Authors: Andrey I. Murzin, Kirill A. Elfimov, Natalia M. Gashnikova
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pathogens
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Online Access:https://www.mdpi.com/2076-0817/14/1/15
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author Andrey I. Murzin
Kirill A. Elfimov
Natalia M. Gashnikova
author_facet Andrey I. Murzin
Kirill A. Elfimov
Natalia M. Gashnikova
author_sort Andrey I. Murzin
collection DOAJ
description Human Immunodeficiency Virus (HIV) proviral reservoirs are cells that harbor integrated HIV proviral DNA within their nuclear genomes. These cells form a heterogeneous group, represented by peripheral blood mononuclear cells (PBMCs), tissue-resident lymphoid and monocytic cells, and glial cells of the central nervous system. The importance of studying the properties of proviral reservoirs is connected with the inaccessibility of integrated HIV proviral DNA for modern anti-retroviral therapies (ARTs) that block virus reproduction. If treatment is not effective enough or is interrupted, the proviral reservoir can reactivate. Early initiation of ART improves the prognosis of the course of HIV infection, which is explained by the reduction in the proviral reservoir pool observed in the early stages of the disease. Different HIV subtypes present differences in the number of latent reservoirs, as determined by structural and functional differences. Unique signatures of patients with HIV, such as elite controllers, have control over viral replication and can be said to have achieved a functional cure for HIV infection. Uncovering the causes of this phenomenon will bring humanity closer to curing HIV infection, potential approaches to which include stem cell transplantation, clustered regularly interspaced short palindromic repeats (CRISPR)/cas9, “Shock and kill”, “Block and lock”, and the application of broad-spectrum neutralizing antibodies (bNAbs).
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spelling doaj-art-a41aad0a89f9431983df3e2d01f3e8682025-01-24T13:44:36ZengMDPI AGPathogens2076-08172024-12-011411510.3390/pathogens14010015The Proviral Reservoirs of Human Immunodeficiency Virus (HIV) InfectionAndrey I. Murzin0Kirill A. Elfimov1Natalia M. Gashnikova2State Research Center of Virology and Biotechnology “Vector”, Koltsovo 630559, RussiaState Research Center of Virology and Biotechnology “Vector”, Koltsovo 630559, RussiaState Research Center of Virology and Biotechnology “Vector”, Koltsovo 630559, RussiaHuman Immunodeficiency Virus (HIV) proviral reservoirs are cells that harbor integrated HIV proviral DNA within their nuclear genomes. These cells form a heterogeneous group, represented by peripheral blood mononuclear cells (PBMCs), tissue-resident lymphoid and monocytic cells, and glial cells of the central nervous system. The importance of studying the properties of proviral reservoirs is connected with the inaccessibility of integrated HIV proviral DNA for modern anti-retroviral therapies (ARTs) that block virus reproduction. If treatment is not effective enough or is interrupted, the proviral reservoir can reactivate. Early initiation of ART improves the prognosis of the course of HIV infection, which is explained by the reduction in the proviral reservoir pool observed in the early stages of the disease. Different HIV subtypes present differences in the number of latent reservoirs, as determined by structural and functional differences. Unique signatures of patients with HIV, such as elite controllers, have control over viral replication and can be said to have achieved a functional cure for HIV infection. Uncovering the causes of this phenomenon will bring humanity closer to curing HIV infection, potential approaches to which include stem cell transplantation, clustered regularly interspaced short palindromic repeats (CRISPR)/cas9, “Shock and kill”, “Block and lock”, and the application of broad-spectrum neutralizing antibodies (bNAbs).https://www.mdpi.com/2076-0817/14/1/15HIV-1proviral reservoirHIV latencyHIV cureARTHIV subtype
spellingShingle Andrey I. Murzin
Kirill A. Elfimov
Natalia M. Gashnikova
The Proviral Reservoirs of Human Immunodeficiency Virus (HIV) Infection
Pathogens
HIV-1
proviral reservoir
HIV latency
HIV cure
ART
HIV subtype
title The Proviral Reservoirs of Human Immunodeficiency Virus (HIV) Infection
title_full The Proviral Reservoirs of Human Immunodeficiency Virus (HIV) Infection
title_fullStr The Proviral Reservoirs of Human Immunodeficiency Virus (HIV) Infection
title_full_unstemmed The Proviral Reservoirs of Human Immunodeficiency Virus (HIV) Infection
title_short The Proviral Reservoirs of Human Immunodeficiency Virus (HIV) Infection
title_sort proviral reservoirs of human immunodeficiency virus hiv infection
topic HIV-1
proviral reservoir
HIV latency
HIV cure
ART
HIV subtype
url https://www.mdpi.com/2076-0817/14/1/15
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