The impact of REM-sleep behavior disorder on people with Parkinson’s disease and their partners
Abstract REM-sleep behavior disorder (RBD) may affect health-related quality of life (HRQoL) of people with Parkinson’s disease (PwP) and partners. We aimed to determine how RBD affects HRQoL using a mixed-methods approach. Quantitatively, we analyzed data from the PRIME-NL Parkinson Evaluation stud...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-00986-1 |
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| Summary: | Abstract REM-sleep behavior disorder (RBD) may affect health-related quality of life (HRQoL) of people with Parkinson’s disease (PwP) and partners. We aimed to determine how RBD affects HRQoL using a mixed-methods approach. Quantitatively, we analyzed data from the PRIME-NL Parkinson Evaluation study, including 829 PwP and 452 partners, using multivariable regression models to examine the association between screen-positive RBD and HRQoL. Qualitatively, we conducted interviews with 14 dyads of PwP with self-reported RBD and their partners. RBD was negatively associated with HRQoL in both groups, primarily due to short-term effects on daily life, co-existing symptoms like impaired cognition and autonomic issues, and sleep disturbances. Impact of RBD was already felt before or during the diagnostic process, with the main challenges being sleep-related complaints, anxiety and impact on relationships. PwP and partners employed both medical and non-medical coping strategies. These findings will help to optimize care for PwP with RBD and their partners. |
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| ISSN: | 2373-8057 |