A Direct Comparative Analysis of HPV DNA with Single-Molecule RNA and p16INK4a Protein Expression in Lichen Sclerosus: Implications for Diagnostics and Pathogenesis

A Direct Comparative Analysis of HPV DNA with Single-Molecule RNA and p16INK4a Protein Expression in Lichen Sclerosus: Implications for Diagnostics and Pathogenesis

Introduction: Emerging evidence suggests a relationship between chronic, intermittent, occluded exposure of a susceptible epithelium to urine and male genital lichen sclerosus (MGLSc), although human papillomavirus (HPV) may also play a role. Aims and methods: This study investigated the association...

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Bibliographic Details
Main Authors: Georgios Kravvas, Boyu Xie, Clarisse Ganier, Henk van den Munckhof, Ellen van den Munckhof, Maurits de Koning, Sandra Jerkovic Gulin, Alex Freeman, Aiman Haider, Hussain Alnajjar, Asif Muneer, Magnus Lynch, Michael Millar, Aamir Ahmed, Christopher Barry Bunker
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:JID Innovations
Subjects:
Gene transcription
Inflammatory skin diseases
Papillomavirus
RNA biology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2667026725000232
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