Mono-allelic epigenetic regulation of polycistronic transcription initiation by RNA polymerase II in Trypanosoma brucei

ABSTRACT Unique for a eukaryote, protein-coding genes in trypanosomes are arranged in polycistronic transcription units (PTUs). This genome arrangement has led to a model where Pol II transcription of PTUs is unregulated and changes in gene expression are entirely post-transcriptional. Trypanosoma b...

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Bibliographic Details
Main Authors: Rudo Kieft, Laura Cliffe, Haidong Yan, Robert J. Schmitz, Stephen L. Hajduk, Robert Sabatini
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:mBio
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Online Access:https://journals.asm.org/doi/10.1128/mbio.02328-24
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