Microwave-Assisted Synthesis of 3,5-Dibenzyl-4-amino-1,2,4-triazole and its Diazo Ligand, Metal Complexes Along with Anticancer Activity
Synthesis of 3,5-dibenzyl-4-amino-1,2,4-triazole was accomplished via a conventional method as well as microwave irradiation method, followed by diazotization and coupling with 2,4-pentanedione. The dinucleating ligand was isolated and complexed with Ni(II), Cu(II) and Ru(III) chlorides. These comp...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/569605 |
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| author | Anjali Jha Y. L. N. Murthy G. Durga T. T. Sundari |
| author_facet | Anjali Jha Y. L. N. Murthy G. Durga T. T. Sundari |
| author_sort | Anjali Jha |
| collection | DOAJ |
| description | Synthesis of 3,5-dibenzyl-4-amino-1,2,4-triazole was accomplished via a conventional method as well as microwave irradiation method, followed by diazotization and coupling with 2,4-pentanedione. The dinucleating ligand was isolated and complexed with Ni(II), Cu(II) and Ru(III) chlorides. These complexes were screened on Jurkat, Raji & PBMC cell lines for anticancer activity. Ruthenium complexes showed potential anticancer activities. |
| format | Article |
| id | doaj-art-a40f7e9bf7564d07813cdc5256d94dcb |
| institution | OA Journals |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-a40f7e9bf7564d07813cdc5256d94dcb2025-08-20T02:20:20ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-01741571157710.1155/2010/569605Microwave-Assisted Synthesis of 3,5-Dibenzyl-4-amino-1,2,4-triazole and its Diazo Ligand, Metal Complexes Along with Anticancer ActivityAnjali Jha0Y. L. N. Murthy1G. Durga2T. T. Sundari3Department of Chemistry, Gitam Institute of Science, GITAM University, Rushikonda, IndiaDepartment of Organic Chemistry and FDW, Andhra University, IndiaDepartment of Chemistry, St. Josephs College for Women, Visakhapatnam, 530004, IndiaNFMC, Bharatidasan University, Tiruchirapalli, 620024, IndiaSynthesis of 3,5-dibenzyl-4-amino-1,2,4-triazole was accomplished via a conventional method as well as microwave irradiation method, followed by diazotization and coupling with 2,4-pentanedione. The dinucleating ligand was isolated and complexed with Ni(II), Cu(II) and Ru(III) chlorides. These complexes were screened on Jurkat, Raji & PBMC cell lines for anticancer activity. Ruthenium complexes showed potential anticancer activities.http://dx.doi.org/10.1155/2010/569605 |
| spellingShingle | Anjali Jha Y. L. N. Murthy G. Durga T. T. Sundari Microwave-Assisted Synthesis of 3,5-Dibenzyl-4-amino-1,2,4-triazole and its Diazo Ligand, Metal Complexes Along with Anticancer Activity E-Journal of Chemistry |
| title | Microwave-Assisted Synthesis of 3,5-Dibenzyl-4-amino-1,2,4-triazole and its Diazo Ligand, Metal Complexes Along with Anticancer Activity |
| title_full | Microwave-Assisted Synthesis of 3,5-Dibenzyl-4-amino-1,2,4-triazole and its Diazo Ligand, Metal Complexes Along with Anticancer Activity |
| title_fullStr | Microwave-Assisted Synthesis of 3,5-Dibenzyl-4-amino-1,2,4-triazole and its Diazo Ligand, Metal Complexes Along with Anticancer Activity |
| title_full_unstemmed | Microwave-Assisted Synthesis of 3,5-Dibenzyl-4-amino-1,2,4-triazole and its Diazo Ligand, Metal Complexes Along with Anticancer Activity |
| title_short | Microwave-Assisted Synthesis of 3,5-Dibenzyl-4-amino-1,2,4-triazole and its Diazo Ligand, Metal Complexes Along with Anticancer Activity |
| title_sort | microwave assisted synthesis of 3 5 dibenzyl 4 amino 1 2 4 triazole and its diazo ligand metal complexes along with anticancer activity |
| url | http://dx.doi.org/10.1155/2010/569605 |
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