A randomized controlled trial to test the efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity in patients with head and neck cancer

A randomized controlled trial to test the efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity in patients with head and neck cancer

Abstract Background Cisplatin-induced hearing loss is frequent and severe. Antioxidants such as sodium thiosulfate (STS) can neutralize the effects of cisplatin. The objective of the trial was to test the efficacy of trans-tympanic injections of a STS gel to prevent cisplatin-induced ototoxicity. Me...

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Bibliographic Details
Main Authors: Viannique Rolland, François Meyer, Matthieu J. Guitton, Richard Bussières, Daniel Philippon, Isabelle Bairati, Mathieu Leclerc, Mathieu Côté
Format: Article
Language:English
Published: SAGE Publishing 2019-01-01
Series:Journal of Otolaryngology - Head and Neck Surgery
Subjects:
Head and neck cancer
Cisplatin
Ototoxicity
Trans-tympanic injection
Sodium thiosulfate
Quality of life
Online Access:http://link.springer.com/article/10.1186/s40463-019-0327-x
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