GABA and astrocytic cholesterol determine the lipid environment of GABAAR in cultured cortical neurons

GABA and astrocytic cholesterol determine the lipid environment of GABAAR in cultured cortical neurons

Abstract The γ-aminobutyric acid (GABA) type A receptor (GABAAR), a GABA activated pentameric chloride channel, mediates fast inhibitory neurotransmission in the brain. The lipid environment is critical for GABAAR function. How lipids regulate the channel in the cell membrane is not fully understood...

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Bibliographic Details
Main Authors: Zixuan Yuan, Mahmud Arif Pavel, Scott B. Hansen
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08026-7
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