Response to Interferon-Free Direct Antivirals (DAAS) Treatment in HCV-Related Subcutaneous Lipoma-Like Marginal Zone B-Cell Lymphoma
In 2010 a new entity termed “lipoma-like” HCV related marginal zone B-NHL was described. The etiological link between HCV infection and B-NHL has been extensively investigated in several epidemiological, biological and therapeutic studies and large experiences in literature demonstrated indolent l...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2019-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://mjhid.org/index.php/mjhid/article/view/3975 |
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| author | Maria Lucia De Luca Laura Lombardi Germana Tartaglia Francesca Fazio Alessio Di Prima Laura Cesini Alessandra Serrao Martina Canichella Alessandro Pulsoni |
| author_facet | Maria Lucia De Luca Laura Lombardi Germana Tartaglia Francesca Fazio Alessio Di Prima Laura Cesini Alessandra Serrao Martina Canichella Alessandro Pulsoni |
| author_sort | Maria Lucia De Luca |
| collection | DOAJ |
| description | In 2010 a new entity termed “lipoma-like” HCV related marginal zone B-NHL was described.
The etiological link between HCV infection and B-NHL has been extensively investigated in several epidemiological, biological and therapeutic studies and large experiences in literature demonstrated indolent lymphoma’s regression after antiviral therapy.
HCV-related indolent NHL response to interferon-ribavirin-based antiviral therapy is well documented, while evidence of the efficacy of interferon-free direct-acting antivirals (DAAs) in this subset of lymphoma is also currently increasing. In this article we report two cases of HCV-related subcutaneous “lipoma-like” Marginal Zone B-cell lymphoma, treated with DAAs. Sustained virological response (SVR) with reduction of MZL localizations, persisting to date, were obtained in both patients. These data originally demonstrate the efficacy of DAAs in this rare entity. |
| format | Article |
| id | doaj-art-a4010b9e1f3d41f29bf228470d49fd8b |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-a4010b9e1f3d41f29bf228470d49fd8b2025-01-02T10:41:49ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062019-08-0111110.4084/mjhid.2019.053Response to Interferon-Free Direct Antivirals (DAAS) Treatment in HCV-Related Subcutaneous Lipoma-Like Marginal Zone B-Cell LymphomaMaria Lucia De Luca0Laura Lombardi1Germana Tartaglia2Francesca Fazio3Alessio Di Prima4Laura Cesini5Alessandra Serrao6Martina Canichella7Alessandro Pulsoni8Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome,Service D’Hématologie, Hôpital Simone Veil, TroyesHematology, Department of Translational and Precision Medicine, Sapienza University of RomeHematology, Department of Translational and Precision Medicine, Sapienza University of RomeHematology, Department of Translational and Precision Medicine, Sapienza University of RomeHematology, Department of Translational and Precision Medicine, Sapienza University of RomeHematology, Department of Translational and Precision Medicine, Sapienza University of RomeHematology, Department of Translational and Precision Medicine, Sapienza University of RomeDivision of Hematology, Dipartimento di Biotecnologie Cellulari ed Ematologia, La Sapienza University, via Benevento 6, 00161 Rome, Italy.In 2010 a new entity termed “lipoma-like” HCV related marginal zone B-NHL was described. The etiological link between HCV infection and B-NHL has been extensively investigated in several epidemiological, biological and therapeutic studies and large experiences in literature demonstrated indolent lymphoma’s regression after antiviral therapy. HCV-related indolent NHL response to interferon-ribavirin-based antiviral therapy is well documented, while evidence of the efficacy of interferon-free direct-acting antivirals (DAAs) in this subset of lymphoma is also currently increasing. In this article we report two cases of HCV-related subcutaneous “lipoma-like” Marginal Zone B-cell lymphoma, treated with DAAs. Sustained virological response (SVR) with reduction of MZL localizations, persisting to date, were obtained in both patients. These data originally demonstrate the efficacy of DAAs in this rare entity.http://mjhid.org/index.php/mjhid/article/view/3975HCV, B-NHL, lipoma-like Marginal Zone Lymphoma, Direct-acting antiviral (DAAs) |
| spellingShingle | Maria Lucia De Luca Laura Lombardi Germana Tartaglia Francesca Fazio Alessio Di Prima Laura Cesini Alessandra Serrao Martina Canichella Alessandro Pulsoni Response to Interferon-Free Direct Antivirals (DAAS) Treatment in HCV-Related Subcutaneous Lipoma-Like Marginal Zone B-Cell Lymphoma Mediterranean Journal of Hematology and Infectious Diseases HCV, B-NHL, lipoma-like Marginal Zone Lymphoma, Direct-acting antiviral (DAAs) |
| title | Response to Interferon-Free Direct Antivirals (DAAS) Treatment in HCV-Related Subcutaneous Lipoma-Like Marginal Zone B-Cell Lymphoma |
| title_full | Response to Interferon-Free Direct Antivirals (DAAS) Treatment in HCV-Related Subcutaneous Lipoma-Like Marginal Zone B-Cell Lymphoma |
| title_fullStr | Response to Interferon-Free Direct Antivirals (DAAS) Treatment in HCV-Related Subcutaneous Lipoma-Like Marginal Zone B-Cell Lymphoma |
| title_full_unstemmed | Response to Interferon-Free Direct Antivirals (DAAS) Treatment in HCV-Related Subcutaneous Lipoma-Like Marginal Zone B-Cell Lymphoma |
| title_short | Response to Interferon-Free Direct Antivirals (DAAS) Treatment in HCV-Related Subcutaneous Lipoma-Like Marginal Zone B-Cell Lymphoma |
| title_sort | response to interferon free direct antivirals daas treatment in hcv related subcutaneous lipoma like marginal zone b cell lymphoma |
| topic | HCV, B-NHL, lipoma-like Marginal Zone Lymphoma, Direct-acting antiviral (DAAs) |
| url | http://mjhid.org/index.php/mjhid/article/view/3975 |
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