Condition of nasopharynx contamination in children with chronic tonsillitis and gastroesophageal reflux disease
The aim was to study the condition of nasopharynx contamination in children with chronic tonsillitis depending on the presence of pathological gastro-esophageal reflux. Materials and methods. In total, 44 children aged 4.60 ± 0.14 years were enrolled in the study. The index group comprised 22 peo...
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Zaporizhzhia State Medical and Pharmaceutical University
2019-10-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/179441/180254 |
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| author | L. M. Boiarska L. V. Hrebeniuk K. O. Ivanova V.V. Akhtyrsky |
| author_facet | L. M. Boiarska L. V. Hrebeniuk K. O. Ivanova V.V. Akhtyrsky |
| author_sort | L. M. Boiarska |
| collection | DOAJ |
| description | The aim was to study the condition of nasopharynx contamination in children with chronic tonsillitis depending on the presence of pathological gastro-esophageal reflux.
Materials and methods. In total, 44 children aged 4.60 ± 0.14 years were enrolled in the study. The index group comprised 22 people with chronic tonsillitis and gastroesophageal reflux disease (GERD); the control group consisted of 22 people with chronic tonsillitis but without GERD. Samples of nasopharynx secretion (pharyngeal and nasal swabs) were taken for culture and their results were analyzed. The results were statistically processed with the use of Microsoft Office Excel and Statistica 13 software.
Results. It was found that pharyngeal cultures obtained from children of the index group tended to reveal H. influenzae in the swab more frequently (in 77.3 %, P = 0.06). This microorganism was revealed in nasal cultures of children with GERD (in 31.8 %, P = 0.02) and only in mixed and acid reflux (30.0 % and 80.0 %, respectively). 63.6 % of children from the index group were culture positive for more than two microorganisms, which was typical for half of the children with mixed and acid reflux (13.6 %, P = 0.002). It was defined that children with GERD and colonized by H. influenzae, demonstrated higher rates of total quantity of acid reflux (193.86 ± 40.46 compared to 104.80 ± 2.06, P = 0.05), persistent acid reflux (7.50 ± 1.62 compared to 3.67 ± 1.20, P = 0.04), as well as percentage of acid reflux per day (26.17 ± 7.23 compared to 7.44 ± 2.06, P = 0.004).
Conclusions. Contamination of pharyngeal and nasal mucous membranes in children with GERD and chronic tonsillitis was represented by potentially pathogenic bacterial microflora (in 95.5 %) with the prevalence of H. influenzae. More than two microorganisms were revealed in children with mixed and acid reflux (P = 0.05). Children with GERD and chronic tonsillitis, provided H. influenzae colonization, demonstrated higher rates of total quantity of acid reflux (P = 0.05), persistent acid reflux (P = 0.04), as well as percentage of acid reflux per day (P = 0.004). |
| format | Article |
| id | doaj-art-a40032e81a9b422586033b3d46d6f5c1 |
| institution | Kabale University |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2019-10-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-a40032e81a9b422586033b3d46d6f5c12025-08-20T03:38:26ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102019-10-0121565065510.14739/2310-1210.2019.5.179441Condition of nasopharynx contamination in children with chronic tonsillitis and gastroesophageal reflux diseaseL. M. BoiarskaL. V. HrebeniukK. O. IvanovaV.V. AkhtyrskyThe aim was to study the condition of nasopharynx contamination in children with chronic tonsillitis depending on the presence of pathological gastro-esophageal reflux. Materials and methods. In total, 44 children aged 4.60 ± 0.14 years were enrolled in the study. The index group comprised 22 people with chronic tonsillitis and gastroesophageal reflux disease (GERD); the control group consisted of 22 people with chronic tonsillitis but without GERD. Samples of nasopharynx secretion (pharyngeal and nasal swabs) were taken for culture and their results were analyzed. The results were statistically processed with the use of Microsoft Office Excel and Statistica 13 software. Results. It was found that pharyngeal cultures obtained from children of the index group tended to reveal H. influenzae in the swab more frequently (in 77.3 %, P = 0.06). This microorganism was revealed in nasal cultures of children with GERD (in 31.8 %, P = 0.02) and only in mixed and acid reflux (30.0 % and 80.0 %, respectively). 63.6 % of children from the index group were culture positive for more than two microorganisms, which was typical for half of the children with mixed and acid reflux (13.6 %, P = 0.002). It was defined that children with GERD and colonized by H. influenzae, demonstrated higher rates of total quantity of acid reflux (193.86 ± 40.46 compared to 104.80 ± 2.06, P = 0.05), persistent acid reflux (7.50 ± 1.62 compared to 3.67 ± 1.20, P = 0.04), as well as percentage of acid reflux per day (26.17 ± 7.23 compared to 7.44 ± 2.06, P = 0.004). Conclusions. Contamination of pharyngeal and nasal mucous membranes in children with GERD and chronic tonsillitis was represented by potentially pathogenic bacterial microflora (in 95.5 %) with the prevalence of H. influenzae. More than two microorganisms were revealed in children with mixed and acid reflux (P = 0.05). Children with GERD and chronic tonsillitis, provided H. influenzae colonization, demonstrated higher rates of total quantity of acid reflux (P = 0.05), persistent acid reflux (P = 0.04), as well as percentage of acid reflux per day (P = 0.004).http://zmj.zsmu.edu.ua/article/view/179441/180254gastroesophageal reflux diseasechronic tonsillitischildrenpreschool childpathological gastroesophageal reflux |
| spellingShingle | L. M. Boiarska L. V. Hrebeniuk K. O. Ivanova V.V. Akhtyrsky Condition of nasopharynx contamination in children with chronic tonsillitis and gastroesophageal reflux disease Zaporožskij Medicinskij Žurnal gastroesophageal reflux disease chronic tonsillitis children preschool child pathological gastroesophageal reflux |
| title | Condition of nasopharynx contamination in children with chronic tonsillitis and gastroesophageal reflux disease |
| title_full | Condition of nasopharynx contamination in children with chronic tonsillitis and gastroesophageal reflux disease |
| title_fullStr | Condition of nasopharynx contamination in children with chronic tonsillitis and gastroesophageal reflux disease |
| title_full_unstemmed | Condition of nasopharynx contamination in children with chronic tonsillitis and gastroesophageal reflux disease |
| title_short | Condition of nasopharynx contamination in children with chronic tonsillitis and gastroesophageal reflux disease |
| title_sort | condition of nasopharynx contamination in children with chronic tonsillitis and gastroesophageal reflux disease |
| topic | gastroesophageal reflux disease chronic tonsillitis children preschool child pathological gastroesophageal reflux |
| url | http://zmj.zsmu.edu.ua/article/view/179441/180254 |
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