Rio Mamore Hantavirus Endemicity, Peruvian Amazon, 2020
To explore hantavirus infection patterns in Latin America, we conducted molecular and serologic hantavirus investigations among 3,400 febrile patients from Peru during 2020–2021. Reverse transcription PCR indicated that a patient from Loreto, in the Peruvian Amazon, was positive for Rio Mamore hant...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2024-12-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/30/12/24-0249_article |
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| author | Marta Piche-Ovares Maria Paquita García Andres Moreira-Soto Maribel Dana Figueroa-Romero Nancy Susy Merino-Sarmiento Adolfo Ismael Marcelo-Ñique Edward Málaga-Trillo Dora Esther Valencia Manosalva Miladi Gatty-Nogueira César Augusto Cabezas Sanchez Jan Felix Drexler |
| author_facet | Marta Piche-Ovares Maria Paquita García Andres Moreira-Soto Maribel Dana Figueroa-Romero Nancy Susy Merino-Sarmiento Adolfo Ismael Marcelo-Ñique Edward Málaga-Trillo Dora Esther Valencia Manosalva Miladi Gatty-Nogueira César Augusto Cabezas Sanchez Jan Felix Drexler |
| author_sort | Marta Piche-Ovares |
| collection | DOAJ |
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To explore hantavirus infection patterns in Latin America, we conducted molecular and serologic hantavirus investigations among 3,400 febrile patients from Peru during 2020–2021. Reverse transcription PCR indicated that a patient from Loreto, in the Peruvian Amazon, was positive for Rio Mamore hantavirus (serum, 3.8 × 103 copies/mL). High genomic sequence identity of 87.0%–94.8% and phylogenetic common ancestry with a rodent-associated Rio Mamore hantavirus from Loreto in 1996 indicated endemicity. In 832 samples from Loreto, hantavirus incidence based on IgM ELISA of pooled Sin Nombre (SNV) and Andes virus (ANDV) nucleoproteins and immunofluorescence assay–based end-point titration using SNV/ANDV/Hantaan/Puumala/Saarema/Dobrava/Seoul hantaviruses was 0.5%. Across 3 ecologically distinct departments in Peru, SNV/ANDV IgG ELISA/IFA–based reactivity was 1.7%, suggesting circulation of antigenically distinct New World hantaviruses. Testing for arboviruses, nonendemic pathogens, and antigen-free ELISA corroborated nonspecific reactivity in 2 IgG and several IgM ELISA–positive serum samples. Hantavirus diagnostics and surveillance should be strengthened in Peru ad across Latin America.
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| format | Article |
| id | doaj-art-a3fe0139755044eeb5b6519a53ef5b2b |
| institution | OA Journals |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-a3fe0139755044eeb5b6519a53ef5b2b2025-08-20T02:28:32ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592024-12-0130122532254310.3201/eid3012.240249Rio Mamore Hantavirus Endemicity, Peruvian Amazon, 2020Marta Piche-OvaresMaria Paquita GarcíaAndres Moreira-SotoMaribel Dana Figueroa-RomeroNancy Susy Merino-SarmientoAdolfo Ismael Marcelo-ÑiqueEdward Málaga-TrilloDora Esther Valencia ManosalvaMiladi Gatty-NogueiraCésar Augusto Cabezas SanchezJan Felix Drexler To explore hantavirus infection patterns in Latin America, we conducted molecular and serologic hantavirus investigations among 3,400 febrile patients from Peru during 2020–2021. Reverse transcription PCR indicated that a patient from Loreto, in the Peruvian Amazon, was positive for Rio Mamore hantavirus (serum, 3.8 × 103 copies/mL). High genomic sequence identity of 87.0%–94.8% and phylogenetic common ancestry with a rodent-associated Rio Mamore hantavirus from Loreto in 1996 indicated endemicity. In 832 samples from Loreto, hantavirus incidence based on IgM ELISA of pooled Sin Nombre (SNV) and Andes virus (ANDV) nucleoproteins and immunofluorescence assay–based end-point titration using SNV/ANDV/Hantaan/Puumala/Saarema/Dobrava/Seoul hantaviruses was 0.5%. Across 3 ecologically distinct departments in Peru, SNV/ANDV IgG ELISA/IFA–based reactivity was 1.7%, suggesting circulation of antigenically distinct New World hantaviruses. Testing for arboviruses, nonendemic pathogens, and antigen-free ELISA corroborated nonspecific reactivity in 2 IgG and several IgM ELISA–positive serum samples. Hantavirus diagnostics and surveillance should be strengthened in Peru ad across Latin America. https://wwwnc.cdc.gov/eid/article/30/12/24-0249_articleRio Mamore virushantavirusesserologygenomeecologyviruses |
| spellingShingle | Marta Piche-Ovares Maria Paquita García Andres Moreira-Soto Maribel Dana Figueroa-Romero Nancy Susy Merino-Sarmiento Adolfo Ismael Marcelo-Ñique Edward Málaga-Trillo Dora Esther Valencia Manosalva Miladi Gatty-Nogueira César Augusto Cabezas Sanchez Jan Felix Drexler Rio Mamore Hantavirus Endemicity, Peruvian Amazon, 2020 Emerging Infectious Diseases Rio Mamore virus hantaviruses serology genome ecology viruses |
| title | Rio Mamore Hantavirus Endemicity, Peruvian Amazon, 2020 |
| title_full | Rio Mamore Hantavirus Endemicity, Peruvian Amazon, 2020 |
| title_fullStr | Rio Mamore Hantavirus Endemicity, Peruvian Amazon, 2020 |
| title_full_unstemmed | Rio Mamore Hantavirus Endemicity, Peruvian Amazon, 2020 |
| title_short | Rio Mamore Hantavirus Endemicity, Peruvian Amazon, 2020 |
| title_sort | rio mamore hantavirus endemicity peruvian amazon 2020 |
| topic | Rio Mamore virus hantaviruses serology genome ecology viruses |
| url | https://wwwnc.cdc.gov/eid/article/30/12/24-0249_article |
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