Intrathecal pemetrexed efficacy and cerebrospinal fluid tumor marker response in refractory leptomeningeal metastasis of non-small-cell lung cancer: a single-arm phase II trial

Intrathecal pemetrexed efficacy and cerebrospinal fluid tumor marker response in refractory leptomeningeal metastasis of non-small-cell lung cancer: a single-arm phase II trial

Abstract Background The treatments for refractory leptomeningeal metastasis (RLM) of non-small cell lung cancer (NSCLC) are limited, and response assessment is complex and challenging. This clinical trial aimed to evaluate the efficacy of intrathecal pemetrexed (IP) and response assessment using cer...

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Main Authors: Qingsheng Xu, Kaiyuan Huang, Luqing Tong, Danfang Yan, Yilei Zhao, Hanjin Yang, Weili Jin, Luyuan Zhang, Jinquan Cai, Qun Chen
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Medicine
Subjects:
Intrathecal pemetrexed
Response assessment
Tumor marker in cerebrospinal fluid
Refractory leptomeningeal metastasis
Non-small-cell lung cancer
Online Access:https://doi.org/10.1186/s12916-025-04134-7
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https://doi.org/10.1186/s12916-025-04134-7

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