Uncommon concurrent pulmonary infections: Aspergillus fumigatus and Lomentospora prolificans in an Anti-MDA5 antibody-positive dermatomyositis patient
A 59-year-old female with anti-MDA5 antibody-positive dermatomyositis was treated with prednisolone, tacrolimus, cyclophosphamide, tofacitinib, and plasma exchange. Five months post-treatment, elevated β-D-glucan levels and a pulmonary shadow on CT were noted. Aspergillus fumigatus was identified, l...
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Elsevier
2025-03-01
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| Series: | Medical Mycology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211753924000630 |
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| author | Maaya Fukumura Ryosuke Hiwa Satomi Yukawa Yasuhiro Tsuchido Hajime Yoshifuji Akio Morinobu |
| author_facet | Maaya Fukumura Ryosuke Hiwa Satomi Yukawa Yasuhiro Tsuchido Hajime Yoshifuji Akio Morinobu |
| author_sort | Maaya Fukumura |
| collection | DOAJ |
| description | A 59-year-old female with anti-MDA5 antibody-positive dermatomyositis was treated with prednisolone, tacrolimus, cyclophosphamide, tofacitinib, and plasma exchange. Five months post-treatment, elevated β-D-glucan levels and a pulmonary shadow on CT were noted. Aspergillus fumigatus was identified, leading to voriconazole initiation. A new pulmonary cavity lesion later revealed Lomentospora prolificans. Considering voriconazole resistance, terbinafine was added, resulting in clinical improvement. Vigilant infection monitoring is crucial during anti-MDA5 antibody-positive dermatomyositis treatment. |
| format | Article |
| id | doaj-art-a3f7f476963c40a290f5144a4f0a4cea |
| institution | DOAJ |
| issn | 2211-7539 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medical Mycology Case Reports |
| spelling | doaj-art-a3f7f476963c40a290f5144a4f0a4cea2025-08-20T02:52:21ZengElsevierMedical Mycology Case Reports2211-75392025-03-014710068910.1016/j.mmcr.2024.100689Uncommon concurrent pulmonary infections: Aspergillus fumigatus and Lomentospora prolificans in an Anti-MDA5 antibody-positive dermatomyositis patientMaaya Fukumura0Ryosuke Hiwa1Satomi Yukawa2Yasuhiro Tsuchido3Hajime Yoshifuji4Akio Morinobu5Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, JapanDepartment of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Corresponding author.Department of Infection Control and Prevention, Kyoto University Hospital, Kyoto, JapanDepartment of Infection Control and Prevention, Kyoto University Hospital, Kyoto, JapanDepartment of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, JapanDepartment of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, JapanA 59-year-old female with anti-MDA5 antibody-positive dermatomyositis was treated with prednisolone, tacrolimus, cyclophosphamide, tofacitinib, and plasma exchange. Five months post-treatment, elevated β-D-glucan levels and a pulmonary shadow on CT were noted. Aspergillus fumigatus was identified, leading to voriconazole initiation. A new pulmonary cavity lesion later revealed Lomentospora prolificans. Considering voriconazole resistance, terbinafine was added, resulting in clinical improvement. Vigilant infection monitoring is crucial during anti-MDA5 antibody-positive dermatomyositis treatment.http://www.sciencedirect.com/science/article/pii/S2211753924000630Anti-MDA5 antibody-positive dermatomyositisRapidly progressive interstitial lung diseaseAspergillus fumigatusLomentospora prolificans |
| spellingShingle | Maaya Fukumura Ryosuke Hiwa Satomi Yukawa Yasuhiro Tsuchido Hajime Yoshifuji Akio Morinobu Uncommon concurrent pulmonary infections: Aspergillus fumigatus and Lomentospora prolificans in an Anti-MDA5 antibody-positive dermatomyositis patient Medical Mycology Case Reports Anti-MDA5 antibody-positive dermatomyositis Rapidly progressive interstitial lung disease Aspergillus fumigatus Lomentospora prolificans |
| title | Uncommon concurrent pulmonary infections: Aspergillus fumigatus and Lomentospora prolificans in an Anti-MDA5 antibody-positive dermatomyositis patient |
| title_full | Uncommon concurrent pulmonary infections: Aspergillus fumigatus and Lomentospora prolificans in an Anti-MDA5 antibody-positive dermatomyositis patient |
| title_fullStr | Uncommon concurrent pulmonary infections: Aspergillus fumigatus and Lomentospora prolificans in an Anti-MDA5 antibody-positive dermatomyositis patient |
| title_full_unstemmed | Uncommon concurrent pulmonary infections: Aspergillus fumigatus and Lomentospora prolificans in an Anti-MDA5 antibody-positive dermatomyositis patient |
| title_short | Uncommon concurrent pulmonary infections: Aspergillus fumigatus and Lomentospora prolificans in an Anti-MDA5 antibody-positive dermatomyositis patient |
| title_sort | uncommon concurrent pulmonary infections aspergillus fumigatus and lomentospora prolificans in an anti mda5 antibody positive dermatomyositis patient |
| topic | Anti-MDA5 antibody-positive dermatomyositis Rapidly progressive interstitial lung disease Aspergillus fumigatus Lomentospora prolificans |
| url | http://www.sciencedirect.com/science/article/pii/S2211753924000630 |
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