Methylation of 45S Ribosomal DNA (rDNA) Is Associated with Cancer and Aging in Humans
Cancer and aging, two distinct processes of cell development, are two major problems threatening our human health and life in current days. Epigenetic studies, especially DNA methylation, have been intensively investigated on them over the years, though a lot of unanswered issues remain. In the huma...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2021/8818007 |
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| author | Fengqing Shao Xiaoqi Liu Xianzhi Zhang Qi Wang Wencai Wang |
| author_facet | Fengqing Shao Xiaoqi Liu Xianzhi Zhang Qi Wang Wencai Wang |
| author_sort | Fengqing Shao |
| collection | DOAJ |
| description | Cancer and aging, two distinct processes of cell development, are two major problems threatening our human health and life in current days. Epigenetic studies, especially DNA methylation, have been intensively investigated on them over the years, though a lot of unanswered issues remain. In the human genome, rDNA is a highly conserved tandem repeat family playing critical roles in protein synthesis, genome stability and integrity, etc. More importantly, rDNA is the significant target of DNA methylation, and a potential association between rDNA methylation and cancer and aging has emerged recently. However, whether there is a general trend that rDNA methylation is associated with cancer and aging remains an open issue. In this study, the involvement of rDNA methylation in a series of records of cancer and aging was investigated and summarized, upon which perspectives about rDNA methylation in cancer and aging were proposed. The results showed that rDNA methylation in most cancer cases displayed a consistent pattern with hypermethylation in the coding region but with hypomethylation in the promoter region, which likely facilitates the proliferation and metastasis of cancerous cells. Distinctively, both the coding and promoter regions of rDNA become increasingly methylated during the process of aging, indicating the decline of rDNA activity. The finding of rDNA methylation also implies its potential application as an epigenetic biomarker in the diagnosis of cancer and aging. This work will shed light on our understanding of the pathogenesis, diagnosis, and treatment of cancer and aging from the perspective of rDNA methylation. |
| format | Article |
| id | doaj-art-a3f49cccf2df40d79d652eea76765a38 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-a3f49cccf2df40d79d652eea76765a382025-02-03T05:49:16ZengWileyInternational Journal of Genomics2314-436X2314-43782021-01-01202110.1155/2021/88180078818007Methylation of 45S Ribosomal DNA (rDNA) Is Associated with Cancer and Aging in HumansFengqing Shao0Xiaoqi Liu1Xianzhi Zhang2Qi Wang3Wencai Wang4Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaDepartment of Horticulture, College of Horticulture and Landscape Architecture, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaCancer and aging, two distinct processes of cell development, are two major problems threatening our human health and life in current days. Epigenetic studies, especially DNA methylation, have been intensively investigated on them over the years, though a lot of unanswered issues remain. In the human genome, rDNA is a highly conserved tandem repeat family playing critical roles in protein synthesis, genome stability and integrity, etc. More importantly, rDNA is the significant target of DNA methylation, and a potential association between rDNA methylation and cancer and aging has emerged recently. However, whether there is a general trend that rDNA methylation is associated with cancer and aging remains an open issue. In this study, the involvement of rDNA methylation in a series of records of cancer and aging was investigated and summarized, upon which perspectives about rDNA methylation in cancer and aging were proposed. The results showed that rDNA methylation in most cancer cases displayed a consistent pattern with hypermethylation in the coding region but with hypomethylation in the promoter region, which likely facilitates the proliferation and metastasis of cancerous cells. Distinctively, both the coding and promoter regions of rDNA become increasingly methylated during the process of aging, indicating the decline of rDNA activity. The finding of rDNA methylation also implies its potential application as an epigenetic biomarker in the diagnosis of cancer and aging. This work will shed light on our understanding of the pathogenesis, diagnosis, and treatment of cancer and aging from the perspective of rDNA methylation.http://dx.doi.org/10.1155/2021/8818007 |
| spellingShingle | Fengqing Shao Xiaoqi Liu Xianzhi Zhang Qi Wang Wencai Wang Methylation of 45S Ribosomal DNA (rDNA) Is Associated with Cancer and Aging in Humans International Journal of Genomics |
| title | Methylation of 45S Ribosomal DNA (rDNA) Is Associated with Cancer and Aging in Humans |
| title_full | Methylation of 45S Ribosomal DNA (rDNA) Is Associated with Cancer and Aging in Humans |
| title_fullStr | Methylation of 45S Ribosomal DNA (rDNA) Is Associated with Cancer and Aging in Humans |
| title_full_unstemmed | Methylation of 45S Ribosomal DNA (rDNA) Is Associated with Cancer and Aging in Humans |
| title_short | Methylation of 45S Ribosomal DNA (rDNA) Is Associated with Cancer and Aging in Humans |
| title_sort | methylation of 45s ribosomal dna rdna is associated with cancer and aging in humans |
| url | http://dx.doi.org/10.1155/2021/8818007 |
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