The Placebo Effect in Chronic Thromboembolic Pulmonary Hypertension Trials: A Systematic Review and Meta-Analysis

The Placebo Effect in Chronic Thromboembolic Pulmonary Hypertension Trials: A Systematic Review and Meta-Analysis

<b>Introduction:</b> Placebo-controlled studies are crucial in clinical trials, but the placebo effect can vary across conditions. We aimed to assess the placebo effect in chronic thromboembolic pulmonary hypertension (CTEPH) trials. <b>Methods:</b> We conducted a systematic...

Full description

Saved in:

Bibliographic Details
Main Authors:	Daniel Caldeira, Daniel Inácio Cazeiro, Rui Plácido, Filipa Ferreira, Rita Calé, Fausto J. Pinto
Format:	Article
Language:	English
Published:	MDPI AG 2025-05-01
Series:	Medical Sciences
Subjects:	chronic thromboembolic pulmonary hypertension (CTEPH) placebo effect clinical trials systematic review meta-analysis 6 min walk test (6MWT)
Online Access:	https://www.mdpi.com/2076-3271/13/2/57
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Comparison of Gait in Women with Degenerative Changes of the Hip Joint and Healthy Women Using the MoKA System—A Pilot Study
by: Maciej Kuś, et al.
Published: (2024-10-01)

Reference equations for the 6-minute walk distance in healthy Portuguese subjects 18–70 years old
by: M.J. Oliveira, et al.
Published: (2019-03-01)

Role of a New Walk Test in Pulmonary Arterial Hypertension: A Retrospective Cohort Study
by: Junhao Jin, et al.
Published: (2025-04-01)

Sarcopenia in Patients with Chronic Thromboembolic Pulmonary Hypertension
by: Steven Hopkins, et al.
Published: (2025-04-01)

Correlation between 6-min Walk Test and Cardiopulmonary Exercise Test in Chinese Patients
by: Pik-Fung Wong, et al.
Published: (2018-04-01)

Progress on omics studies of chronic thromboembolic pulmonary hypertension
by: DUAN Wenxin, SONG Wanlu, YANG Peiran, WANG Jing
Published: (2025-07-01)

An in-depth evaluation of the efficacy and safety of various treatment modalities for chronic thromboembolic pulmonary hypertension: A systematic review and network meta-analysis
by: Noha Rami Ismail, et al.
Published: (2024-10-01)

Effects of different exercises on improving gait performance in patients with Parkinson’s disease: a systematic review and network meta-analysis
by: Ying Li, et al.
Published: (2025-02-01)

Effects of pulmonary rehabilitation program in a community based hospital in California
by: Baljit Ubhi, et al.
Published: (2025-05-01)

Can static hyperinflation predict exercise capacity in COPD?
by: I. Ladeira, et al.
Published: (2023-12-01)

Intermittent Hypoxic–Hyperoxic Training During Inpatient Rehabilitation Improves Exercise Capacity and Functional Outcome in Patients With Long Covid: Results of a Controlled Clinical Pilot Trial
by: Wolfram Doehner, et al.
Published: (2024-12-01)

Coronary-type stent implantation in chronic thromboembolic pulmonary hypertension: a national registry case series
by: Boris Dzudovic, et al.
Published: (2025-06-01)

Characteristics of Daily Walking Bouts as Valid and Reliable Indicators of Exercise Capacity in Pulmonary Arterial Hypertension: Insights From the Randomized Controlled Study With Selexipag (TRACE)
by: Rana Zia Ur Rehman, et al.
Published: (2025-04-01)

Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: Technical challenges and controversies
by: Tom Verbelen, MD, PhD, et al.
Published: (2025-11-01)

Exercise‐Induced Oxygen Desaturation and Heart Rate Response During 6‐Min Walk Test Predict Pulmonary Hypertension in Exertional Dyspnea: A Retrospective Cohort Study
by: Haojie Zhang, et al.
Published: (2025-04-01)

Physical performance on the early 6-minute walk test in coronary artery bypass grafting patients during inpatient cardiac rehabilitation
by: Yao Wu, et al.
Published: (2025-07-01)

Impact of disease location and laterality on hemodynamic response following pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension
by: Bryan O. Pérez Martínez, MD, et al.
Published: (2025-08-01)

Assessment of the Relationship Between the Six‐Minute Walk Test (6MWT) With Serum Chloride Level and Mean Pulmonary Arterial Pressure in Patients With Pulmonary Arterial Hypertension
by: Sepideh Hejazi, et al.
Published: (2025-04-01)

Reference values for the 1-minute sit-to-stand test to assess functional capacity and short-term mortality in people with idiopathic pulmonary fibrosis and fibrotic connective tissue related interstitial lung diseases: a prospective real-world cohort study
by: Meng-Yun Tsai, et al.
Published: (2025-02-01)

Persistent dyspnea in post-coronavirus disease 2019 patients: value of cardiopulmonary exercise test
by: Aliaë A.R. Mohammed Hussein, et al.
Published: (2025-04-01)

Evaluation of the benefits of adapted physical activity in children and adolescents with osteogenesis imperfecta: the MOVE-OI trial
by: Hayssam Al Arab, et al.
Published: (2025-04-01)

MEDICAL TREATMENT OF CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION
by: K. V. Mershin, et al.
Published: (2014-03-01)

A systematic qualitative review of ethical issues in open label placebo in published research
by: Mélina Richard, et al.
Published: (2025-04-01)

Community-based pulmonary rehabilitation for post-TB lung disease – a programmatic intervention
by: B. Stenberg, et al.
Published: (2025-08-01)

Tricuspid annular plane systolic excursion to pulmonary artery systolic pressure ratio in chronic thromboembolic pulmonary hypertension improves with balloon pulmonary angioplasty
by: Jenny Z. Yang, et al.
Published: (2024-10-01)

Therapeutic efficacy of pirfenidone and nintedanib in pulmonary fibrosis; a systematic review and meta-analysis
by: Yiting Qiu, et al.
Published: (2025-07-01)

Telerehabilitation of Chronic Obstructive Pulmonary Disease Patients in a Tertiary Care Hospital in Western India: A 3-month Follow-up Study
by: T. K. Abins, et al.
Published: (2024-05-01)

Placebo and the law of identification
by: Steve F. Bierman, et al.
Published: (2024-12-01)

The Two Sides of Placebo Analgesia: Differential Functional Connectivity Reveals Mechanisms of Placebo Analgesic Response
by: Bush NJ, et al.
Published: (2025-01-01)

MULTICENTER DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED TRIAL OF THE SYMPTOM- AND STRUCTURE-MODIFYING EFFECT OF ALFLUTOP IN PATIENTS WITH KNEE OSTEOARTHROSIS. COMMUNICATION 1. EVALUATION OF THE SYMPTOM-MODIFYING EFFECT OF THE DRUG
by: Lyudmila Ivanovna Alekseeva, et al.
Published: (2013-12-01)

The ethics of placebos
by: Donna Knapp van Bogaert, et al.
Published: (2013-02-01)

Effectiveness of Inspiratory Muscle Training in Individuals with Chronic Venous Disease: A Randomized Controlled Study
by: Cemre Görünmezoğlu, et al.
Published: (2025-02-01)

Arteriovenous Oxygen Content Difference: A Diagnostic Predictor for Preselecting Invasive Treatment in Congenital Heart Disease‐Related Pulmonary Arterial Hypertension
by: Ashfaq Ahmad, et al.
Published: (2025-04-01)

Is pulmonary embolism a chronic disease?
by: Gerard Gurumurthy, et al.
Published: (2025-07-01)

Effectiveness of pulmonary rehabilitation in post-COVID-19 patients: A pre- and post-interventional study
by: Medha Deepak Bargaje, et al.
Published: (2024-12-01)

A nomogram model based on clinical and 3D-EIT parameters for CTEPH diagnosis
by: Jian Xu, et al.
Published: (2025-04-01)

Russian consensus: balloon pulmonary angioplasty in treatment of chronic thromboembolic pulmonary hypertension
by: N. M. Danilov, et al.
Published: (2025-03-01)

Historical milestones of the invention and use of placebo
by: A. N. Koterov
Published: (2023-01-01)

Optimizing physical fitness in chronic stroke patients: the impact of exercise training modality and dosage on maximal and sub-maximal fitness – a systematic review and meta-analysis
by: Felix Nindorera, et al.
Published: (2025-08-01)

ARC (Australian Rotator Cuff) trial: study protocol for a randomised placebo-controlled trial comparing rotator cuff repair to no repair during arthroscopic shoulder surgery for people with shoulder pain and non-acute rotator cuff tears
by: Ian A. Harris, et al.
Published: (2025-04-01)