Transcriptomic profiling of ceftriaxone-tolerant phenotypes of Neisseria gonorrhoeae reveals downregulation of ribosomal genes — a pilot study

Transcriptomic profiling of ceftriaxone-tolerant phenotypes of Neisseria gonorrhoeae reveals downregulation of ribosomal genes — a pilot study

ABSTRACT Antibiotic tolerance is associated with failure of antibiotic treatment and accelerates the development of antimicrobial resistance. The molecular mechanisms underlying antimicrobial tolerance remain poorly understood. Tolerant bacteria can slow metabolism by extending the lag phase without...

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Bibliographic Details
Main Authors: Sheeba Santhini Manoharan-Basil, Margaux Balduck, Zina Gestels, Said Abdellati, Tessa De Block, Chris Kenyon
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
tolerant
RNA-seq
ceftriaxone
WHO P
Neisseria gonorrhoeae
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01207-25
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