Association of player position and functional connectivity alterations in collegiate American football players: an fMRI study
IntroductionResting state-fMRI, provides a sensitive method for detecting changes in brain functional integrity, both with respect to regional oxygenated blood flow and whole network connectivity. The primary goal of this report was to examine alterations in functional connectivity in collegiate Ame...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1511915/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582531767074816 |
|---|---|
| author | Owen Griffith Xiaoxiao Bai Alexa E. Walter Michael Gay Jon Kelly Wayne Sebastianelli Linda Papa Semyon Slobounov |
| author_facet | Owen Griffith Xiaoxiao Bai Alexa E. Walter Michael Gay Jon Kelly Wayne Sebastianelli Linda Papa Semyon Slobounov |
| author_sort | Owen Griffith |
| collection | DOAJ |
| description | IntroductionResting state-fMRI, provides a sensitive method for detecting changes in brain functional integrity, both with respect to regional oxygenated blood flow and whole network connectivity. The primary goal of this report was to examine alterations in functional connectivity in collegiate American football players after a season of repetitive head impact exposure.MethodsCollegiate football players completed a rs-fMRI at pre-season and 1 week into post-season. A seed-based functional connectivity method, isolating the posterior cingulate cortex (PCC), was utilized to create individual functional connectivity maps. During group analysis, first, voxel-wise paired sample t-tests identified significant changes in connectivity from pre- to post-season, by player, and previous concussion history. Second, 10 DMN ROIs were constructed by overlaying an anatomical map over regions of positive correlation from one-sample t-tests of pre-season and post-season. These ROIs, plus the LpCun, were included in linear mix-effect modeling, with position or concussion history as covariates.Results66 players were included (mean age 20.6 years; 100% male; 34 (51.5%) non-speed position players). The 10 DMN ROIs showed no alterations from pre-season to post-season. By concussion history, the right temporal ROI demonstrated a significant effect on baseline functional connectivity (p = 0.03). Speed players, but not non-speed players, demonstrated a significant decrease in functional connectivity in the precuneus from pre- to post-season (p < 0.001).DiscussionThere are region-specific differences functional connectivity related to both position and concussion history in American collegiate football players. Player position affected functional connectivity across a season of football. Position-specific differences in head impact exposure rate and magnitude plays a crucial role in functional connectivity alterations. |
| format | Article |
| id | doaj-art-a3edca7419784389917a209af4f89349 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-a3edca7419784389917a209af4f893492025-01-29T15:33:01ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-01-011510.3389/fneur.2024.15119151511915Association of player position and functional connectivity alterations in collegiate American football players: an fMRI studyOwen Griffith0Xiaoxiao Bai1Alexa E. Walter2Michael Gay3Jon Kelly4Wayne Sebastianelli5Linda Papa6Semyon Slobounov7Department of Kinesiology, Penn State University, 19 Recreation Building, University Park, PA, United StatesSocial, Life, and Engineering Sciences Imaging Center, Social Science Research Institute, Penn State University, 120F Chandlee Laboratory, University Park, University Park, PA, United StatesDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesDepartment of Kinesiology, Penn State University, 19 Recreation Building, University Park, PA, United StatesDepartment of Kinesiology, Penn State University, 19 Recreation Building, University Park, PA, United StatesPenn State Sports Medicine and Physical Therapy, State College, PA, United StatesOrlando Health, Orlando, FL, United StatesDepartment of Kinesiology, Penn State University, 19 Recreation Building, University Park, PA, United StatesIntroductionResting state-fMRI, provides a sensitive method for detecting changes in brain functional integrity, both with respect to regional oxygenated blood flow and whole network connectivity. The primary goal of this report was to examine alterations in functional connectivity in collegiate American football players after a season of repetitive head impact exposure.MethodsCollegiate football players completed a rs-fMRI at pre-season and 1 week into post-season. A seed-based functional connectivity method, isolating the posterior cingulate cortex (PCC), was utilized to create individual functional connectivity maps. During group analysis, first, voxel-wise paired sample t-tests identified significant changes in connectivity from pre- to post-season, by player, and previous concussion history. Second, 10 DMN ROIs were constructed by overlaying an anatomical map over regions of positive correlation from one-sample t-tests of pre-season and post-season. These ROIs, plus the LpCun, were included in linear mix-effect modeling, with position or concussion history as covariates.Results66 players were included (mean age 20.6 years; 100% male; 34 (51.5%) non-speed position players). The 10 DMN ROIs showed no alterations from pre-season to post-season. By concussion history, the right temporal ROI demonstrated a significant effect on baseline functional connectivity (p = 0.03). Speed players, but not non-speed players, demonstrated a significant decrease in functional connectivity in the precuneus from pre- to post-season (p < 0.001).DiscussionThere are region-specific differences functional connectivity related to both position and concussion history in American collegiate football players. Player position affected functional connectivity across a season of football. Position-specific differences in head impact exposure rate and magnitude plays a crucial role in functional connectivity alterations.https://www.frontiersin.org/articles/10.3389/fneur.2024.1511915/fullfunctional connectivityresting state functional magnetic resonance imagingAmerican footballdefault mode networkposterior cingulate cortexprecuneus |
| spellingShingle | Owen Griffith Xiaoxiao Bai Alexa E. Walter Michael Gay Jon Kelly Wayne Sebastianelli Linda Papa Semyon Slobounov Association of player position and functional connectivity alterations in collegiate American football players: an fMRI study Frontiers in Neurology functional connectivity resting state functional magnetic resonance imaging American football default mode network posterior cingulate cortex precuneus |
| title | Association of player position and functional connectivity alterations in collegiate American football players: an fMRI study |
| title_full | Association of player position and functional connectivity alterations in collegiate American football players: an fMRI study |
| title_fullStr | Association of player position and functional connectivity alterations in collegiate American football players: an fMRI study |
| title_full_unstemmed | Association of player position and functional connectivity alterations in collegiate American football players: an fMRI study |
| title_short | Association of player position and functional connectivity alterations in collegiate American football players: an fMRI study |
| title_sort | association of player position and functional connectivity alterations in collegiate american football players an fmri study |
| topic | functional connectivity resting state functional magnetic resonance imaging American football default mode network posterior cingulate cortex precuneus |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1511915/full |
| work_keys_str_mv | AT owengriffith associationofplayerpositionandfunctionalconnectivityalterationsincollegiateamericanfootballplayersanfmristudy AT xiaoxiaobai associationofplayerpositionandfunctionalconnectivityalterationsincollegiateamericanfootballplayersanfmristudy AT alexaewalter associationofplayerpositionandfunctionalconnectivityalterationsincollegiateamericanfootballplayersanfmristudy AT michaelgay associationofplayerpositionandfunctionalconnectivityalterationsincollegiateamericanfootballplayersanfmristudy AT jonkelly associationofplayerpositionandfunctionalconnectivityalterationsincollegiateamericanfootballplayersanfmristudy AT waynesebastianelli associationofplayerpositionandfunctionalconnectivityalterationsincollegiateamericanfootballplayersanfmristudy AT lindapapa associationofplayerpositionandfunctionalconnectivityalterationsincollegiateamericanfootballplayersanfmristudy AT semyonslobounov associationofplayerpositionandfunctionalconnectivityalterationsincollegiateamericanfootballplayersanfmristudy |