Early hemodynamic differences between generalized and focal epilepsy measured by photoplethysmography
Abstract Photoplethysmography (PPG) detects hemodynamic changes during epileptic seizures. This study aim to investigate PPG signals changes during generalized tonic‒clonic seizures (GTCSs) and focal impaired awareness seizures (FIASs). 17 GTCS and 19 FIAS episodes were recorded from 18 patients. Th...
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Nature Portfolio
2025-06-01
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| Online Access: | https://doi.org/10.1038/s41598-025-02127-3 |
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| author | Aoxue Mei Cong Fu Zhao Liu Yujiao Yang Xiongfei Wang Mengyang Wang Jing Wang Zhigang Han Yujie Bo Ke Xu Chongyang Tang Guoming Luan |
| author_facet | Aoxue Mei Cong Fu Zhao Liu Yujiao Yang Xiongfei Wang Mengyang Wang Jing Wang Zhigang Han Yujie Bo Ke Xu Chongyang Tang Guoming Luan |
| author_sort | Aoxue Mei |
| collection | DOAJ |
| description | Abstract Photoplethysmography (PPG) detects hemodynamic changes during epileptic seizures. This study aim to investigate PPG signals changes during generalized tonic‒clonic seizures (GTCSs) and focal impaired awareness seizures (FIASs). 17 GTCS and 19 FIAS episodes were recorded from 18 patients. The 30 min preictal period was divided into three 10-minute intervals. PPG features analyzed were pulse upslope (PUS), maximal compliance (Kmax), and skewness. Features across 3 preictal intervals showed significant reductions compared to the baseline: PUS (F (3,64) = 11.870, p < 0.001), Kmax (F (3,64) = 7.419, p < 0.001) and skewness (F (3,64) = 2.852, p = 0.044) in the GTCS group. PUS (Kruskal–Wallis [K-W] = 22.600, p < 0.001) and Kmax (K-W = 28.110, p < 0.001) in the FIAS group. In the GTCS group, the largest difference was observed 30 min before seizure onset (PUS: p < 0.001, Cohen’s d = 1.843; Kmas: p < 0.001, Cohen’s d = 1.419; skewness: p = 0.043, Cohen’s d = 0.808), whereas this was not the case in the FIAS group. PPG signals showed earlier changes in the GTCS group than in the FIAS group, highlighting their differences and the potential of PPG-based monitoring for early seizure detection. |
| format | Article |
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| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-a3e5675b9a724fc3a8b80c01102f3cb82025-08-20T02:31:04ZengNature PortfolioScientific Reports2045-23222025-06-0115111010.1038/s41598-025-02127-3Early hemodynamic differences between generalized and focal epilepsy measured by photoplethysmographyAoxue Mei0Cong Fu1Zhao Liu2Yujiao Yang3Xiongfei Wang4Mengyang Wang5Jing Wang6Zhigang Han7Yujie Bo8Ke Xu9Chongyang Tang10Guoming Luan11Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical UniversityDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical UniversityDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical UniversityDepartment of Neurology, Sanbo Brain Hospital, Capital Medical UniversityDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical UniversityDepartment of Neurology, Sanbo Brain Hospital, Capital Medical UniversityDepartment of Neurology, Sanbo Brain Hospital, Capital Medical UniversityBeijing Zhengqihe Health Technology Co., LtdDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical UniversityDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical UniversityDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical UniversityDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical UniversityAbstract Photoplethysmography (PPG) detects hemodynamic changes during epileptic seizures. This study aim to investigate PPG signals changes during generalized tonic‒clonic seizures (GTCSs) and focal impaired awareness seizures (FIASs). 17 GTCS and 19 FIAS episodes were recorded from 18 patients. The 30 min preictal period was divided into three 10-minute intervals. PPG features analyzed were pulse upslope (PUS), maximal compliance (Kmax), and skewness. Features across 3 preictal intervals showed significant reductions compared to the baseline: PUS (F (3,64) = 11.870, p < 0.001), Kmax (F (3,64) = 7.419, p < 0.001) and skewness (F (3,64) = 2.852, p = 0.044) in the GTCS group. PUS (Kruskal–Wallis [K-W] = 22.600, p < 0.001) and Kmax (K-W = 28.110, p < 0.001) in the FIAS group. In the GTCS group, the largest difference was observed 30 min before seizure onset (PUS: p < 0.001, Cohen’s d = 1.843; Kmas: p < 0.001, Cohen’s d = 1.419; skewness: p = 0.043, Cohen’s d = 0.808), whereas this was not the case in the FIAS group. PPG signals showed earlier changes in the GTCS group than in the FIAS group, highlighting their differences and the potential of PPG-based monitoring for early seizure detection.https://doi.org/10.1038/s41598-025-02127-3EpilepsyPhotoplethysmographyGeneralized tonic‒clonic seizuresFocal impaired awareness seizures |
| spellingShingle | Aoxue Mei Cong Fu Zhao Liu Yujiao Yang Xiongfei Wang Mengyang Wang Jing Wang Zhigang Han Yujie Bo Ke Xu Chongyang Tang Guoming Luan Early hemodynamic differences between generalized and focal epilepsy measured by photoplethysmography Scientific Reports Epilepsy Photoplethysmography Generalized tonic‒clonic seizures Focal impaired awareness seizures |
| title | Early hemodynamic differences between generalized and focal epilepsy measured by photoplethysmography |
| title_full | Early hemodynamic differences between generalized and focal epilepsy measured by photoplethysmography |
| title_fullStr | Early hemodynamic differences between generalized and focal epilepsy measured by photoplethysmography |
| title_full_unstemmed | Early hemodynamic differences between generalized and focal epilepsy measured by photoplethysmography |
| title_short | Early hemodynamic differences between generalized and focal epilepsy measured by photoplethysmography |
| title_sort | early hemodynamic differences between generalized and focal epilepsy measured by photoplethysmography |
| topic | Epilepsy Photoplethysmography Generalized tonic‒clonic seizures Focal impaired awareness seizures |
| url | https://doi.org/10.1038/s41598-025-02127-3 |
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