The differential effect of Interferon-gamma on acute kidney injury and parasitemia in experimental malaria

The differential effect of Interferon-gamma on acute kidney injury and parasitemia in experimental malaria

Abstract Malaria-associated acute kidney injury (MAKI) is a common complication of Plasmodium infection, affecting ~ 50% of severe malaria cases and associated with increased mortality. However, its immunopathogenesis remains unclear. Interferon-gamma (IFN-gamma) is a crucial cytokine that influence...

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Bibliographic Details
Main Authors: Rebecca Sadler, Hendrik Possemiers, Fran Prenen, Lotte Van Landschoot, Emilie Pollenus, Margot Deckers, Sofie Knoops, Priyanka Koshy, Patrick Matthys, Philippe E. Van den Steen
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Malaria
IFN-γ
Acute kidney injury
Inflammation
Online Access:https://doi.org/10.1038/s41598-025-90473-7
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