Glycosphingolipids as emerging attack points in bladder cancer
Abstract Bladder cancer is a prevalent malignancy associated with significant morbidity and mortality worldwide. Emerging research highlights the critical role of glycosphingolipids (GSLs) in bladder cancer progression. In this review, we examine GSL expression profiles in bladder cancer and explore...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-04-01
|
| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-025-02302-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850145206837444608 |
|---|---|
| author | Inês B. Moreira Falk F. R. Buettner |
| author_facet | Inês B. Moreira Falk F. R. Buettner |
| author_sort | Inês B. Moreira |
| collection | DOAJ |
| description | Abstract Bladder cancer is a prevalent malignancy associated with significant morbidity and mortality worldwide. Emerging research highlights the critical role of glycosphingolipids (GSLs) in bladder cancer progression. In this review, we examine GSL expression profiles in bladder cancer and explore their contributions to key cancer hallmarks, including invasion and metastasis, immune evasion, and resistance to cell death. We further discuss the potential of GSLs as therapeutic targets and non-invasive biomarkers, with an emphasis on recent advances in GSL-targeting strategies. Additionally, we highlight our recent discovery of a novel, patented biomarker for bladder cancer diagnosis, identified using cutting-edge glyco-analytical technologies. |
| format | Article |
| id | doaj-art-a3e4e69987e647359112dfaee7c9fcbc |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-a3e4e69987e647359112dfaee7c9fcbc2025-08-20T02:28:09ZengSpringerDiscover Oncology2730-60112025-04-0116112210.1007/s12672-025-02302-yGlycosphingolipids as emerging attack points in bladder cancerInês B. Moreira0Falk F. R. Buettner1Institute of Clinical Biochemistry, Hannover Medical SchoolInstitute of Clinical Biochemistry, Hannover Medical SchoolAbstract Bladder cancer is a prevalent malignancy associated with significant morbidity and mortality worldwide. Emerging research highlights the critical role of glycosphingolipids (GSLs) in bladder cancer progression. In this review, we examine GSL expression profiles in bladder cancer and explore their contributions to key cancer hallmarks, including invasion and metastasis, immune evasion, and resistance to cell death. We further discuss the potential of GSLs as therapeutic targets and non-invasive biomarkers, with an emphasis on recent advances in GSL-targeting strategies. Additionally, we highlight our recent discovery of a novel, patented biomarker for bladder cancer diagnosis, identified using cutting-edge glyco-analytical technologies.https://doi.org/10.1007/s12672-025-02302-yBladder cancerGlycosphingolipidsBiomarkers |
| spellingShingle | Inês B. Moreira Falk F. R. Buettner Glycosphingolipids as emerging attack points in bladder cancer Discover Oncology Bladder cancer Glycosphingolipids Biomarkers |
| title | Glycosphingolipids as emerging attack points in bladder cancer |
| title_full | Glycosphingolipids as emerging attack points in bladder cancer |
| title_fullStr | Glycosphingolipids as emerging attack points in bladder cancer |
| title_full_unstemmed | Glycosphingolipids as emerging attack points in bladder cancer |
| title_short | Glycosphingolipids as emerging attack points in bladder cancer |
| title_sort | glycosphingolipids as emerging attack points in bladder cancer |
| topic | Bladder cancer Glycosphingolipids Biomarkers |
| url | https://doi.org/10.1007/s12672-025-02302-y |
| work_keys_str_mv | AT inesbmoreira glycosphingolipidsasemergingattackpointsinbladdercancer AT falkfrbuettner glycosphingolipidsasemergingattackpointsinbladdercancer |