Polymyxin Including Therapy Versus Colistin Including Therapy In The Therapy Of Carbapenem-Resistant Gram-Negative Infections: A Retrospective Matched Cohort Study
BACKGROUND-AIM: In this retrospective matched cohort study, we aimed to compare the clinical outcomes of polymyxin b (PMXB) including therapy receiving cases with colistin receiving cases on culture-proven carbapenem-resistant Gram-negative infections (CPCRGNI). METHOD: This study was performed at a...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221371652400184X |
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| author | Merve Mert Vahabi Deniz Akyol Olcay Buse Kenanoğlu Gamze Şanlıdağ Şevket Yeniyol Deniz Dağ Cansu Bulut Avşar Ayşe Önal Şükrü Dirik Meltem Tüğdür Uğur Önal Gökhan Vatansever Seichan Ketentzi Arda Kaya Oğuzhan Acet Nazlıhan Yalçın Buğra Özkara Hilal Sipahi Bilgin Arda Oğuz Reşat Sipahi |
| author_facet | Merve Mert Vahabi Deniz Akyol Olcay Buse Kenanoğlu Gamze Şanlıdağ Şevket Yeniyol Deniz Dağ Cansu Bulut Avşar Ayşe Önal Şükrü Dirik Meltem Tüğdür Uğur Önal Gökhan Vatansever Seichan Ketentzi Arda Kaya Oğuzhan Acet Nazlıhan Yalçın Buğra Özkara Hilal Sipahi Bilgin Arda Oğuz Reşat Sipahi |
| author_sort | Merve Mert Vahabi |
| collection | DOAJ |
| description | BACKGROUND-AIM: In this retrospective matched cohort study, we aimed to compare the clinical outcomes of polymyxin b (PMXB) including therapy receiving cases with colistin receiving cases on culture-proven carbapenem-resistant Gram-negative infections (CPCRGNI). METHOD: This study was performed at a 1800+ bedded tertiary-care hospital. Adult patients with culture proven CRCRGNI (bacteremia, pneumonia etc.) treated with PMXB or colistin including regimens between August 2016 and October 2023 were included.Matching was performed as one PMXB matched to minimum 1 or 2 colistin whenever possible according to the clinical sample infecting strain was yielded (pneumonia vs. pneumonia etc.) RESULTS: A total of 210 patients(72 (36,00%)female, aged 60,26±17,44),79 cases in PMXB group and 131 cases in colistin group diagnosed with CRCRGNI.Sixty strains had colistin susceptibility data and 56(93.3%) strains were sensitive to colistin.OMM in overall cohorts (56.96% in PMXB 58,01% in colistin p:0.881), overall acute kidney injury, overall microbiological success, and overall clinical success at the end of therapy did not differ significantly(Table). OMM in the overall UTI(3/6 50,0% vs 9/12 75,0% p0.288) and pneumonia subgroups(23/35 65,71% vs 46/70 65,71% p:1) were also similar. Both treatment group OMM were similar in Acinetobacter and Klebsiella subgroups, but significantly lower with PMXB in Pseudomonas subgroup (Table).OMM was also similar within known colistin-sensitive cases(34/56 -60,71%) vs others(77/154- 50,0%)(p:0.168). Interestingly, OMM in overall UTI(OMM 3/6-50% vs 7/12-58.3%) was not significantly different, but in favor of PMXB. CONCLUSIONS: PMXB including therapy resulted nonsignificntly less OMM than colistin cohort and significantly less OMM in Pseudomonas subgroup. Nephrotoxicity was nonsignificantly less in PMXB cohort. |
| format | Article |
| id | doaj-art-a3e4363686ee431d99ced4d29836f787 |
| institution | DOAJ |
| issn | 2213-7165 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-a3e4363686ee431d99ced4d29836f7872025-08-20T02:55:57ZengElsevierJournal of Global Antimicrobial Resistance2213-71652024-12-0139310.1016/j.jgar.2024.10.007Polymyxin Including Therapy Versus Colistin Including Therapy In The Therapy Of Carbapenem-Resistant Gram-Negative Infections: A Retrospective Matched Cohort StudyMerve Mert Vahabi0Deniz Akyol1Olcay Buse Kenanoğlu2Gamze Şanlıdağ3Şevket Yeniyol4Deniz Dağ5Cansu Bulut Avşar6Ayşe Önal7Şükrü Dirik8Meltem Tüğdür9Uğur Önal10Gökhan Vatansever11Seichan Ketentzi12Arda Kaya13Oğuzhan Acet14Nazlıhan Yalçın15Buğra Özkara16Hilal Sipahi17Bilgin Arda18Oğuz Reşat Sipahi19Ege University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeKanuni Sultan Süleyman Research and Training Hospital, İstanbul TürkiyEge University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeEge University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeEge University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeEge University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeEge University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeYüksek İhtisas Research and Training Hospital, Bursa, TürkiyeEge University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeEge University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeUludağ University, Faculty of Medicine Infectious Diseases and Clinical Microbiology, Bursa, TürkiyeEge University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeEge University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeEge University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeEge University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeEge University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeEge University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeBornova Health Directorate, İzmir, TürkiyeEge University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeEge University Faculty of Medicine Infectious Diseases and Clinical Microbiology, İzmir, TürkiyeBACKGROUND-AIM: In this retrospective matched cohort study, we aimed to compare the clinical outcomes of polymyxin b (PMXB) including therapy receiving cases with colistin receiving cases on culture-proven carbapenem-resistant Gram-negative infections (CPCRGNI). METHOD: This study was performed at a 1800+ bedded tertiary-care hospital. Adult patients with culture proven CRCRGNI (bacteremia, pneumonia etc.) treated with PMXB or colistin including regimens between August 2016 and October 2023 were included.Matching was performed as one PMXB matched to minimum 1 or 2 colistin whenever possible according to the clinical sample infecting strain was yielded (pneumonia vs. pneumonia etc.) RESULTS: A total of 210 patients(72 (36,00%)female, aged 60,26±17,44),79 cases in PMXB group and 131 cases in colistin group diagnosed with CRCRGNI.Sixty strains had colistin susceptibility data and 56(93.3%) strains were sensitive to colistin.OMM in overall cohorts (56.96% in PMXB 58,01% in colistin p:0.881), overall acute kidney injury, overall microbiological success, and overall clinical success at the end of therapy did not differ significantly(Table). OMM in the overall UTI(3/6 50,0% vs 9/12 75,0% p0.288) and pneumonia subgroups(23/35 65,71% vs 46/70 65,71% p:1) were also similar. Both treatment group OMM were similar in Acinetobacter and Klebsiella subgroups, but significantly lower with PMXB in Pseudomonas subgroup (Table).OMM was also similar within known colistin-sensitive cases(34/56 -60,71%) vs others(77/154- 50,0%)(p:0.168). Interestingly, OMM in overall UTI(OMM 3/6-50% vs 7/12-58.3%) was not significantly different, but in favor of PMXB. CONCLUSIONS: PMXB including therapy resulted nonsignificntly less OMM than colistin cohort and significantly less OMM in Pseudomonas subgroup. Nephrotoxicity was nonsignificantly less in PMXB cohort.http://www.sciencedirect.com/science/article/pii/S221371652400184Xpolymyxinmultidrug resistancecarbapenem resistance |
| spellingShingle | Merve Mert Vahabi Deniz Akyol Olcay Buse Kenanoğlu Gamze Şanlıdağ Şevket Yeniyol Deniz Dağ Cansu Bulut Avşar Ayşe Önal Şükrü Dirik Meltem Tüğdür Uğur Önal Gökhan Vatansever Seichan Ketentzi Arda Kaya Oğuzhan Acet Nazlıhan Yalçın Buğra Özkara Hilal Sipahi Bilgin Arda Oğuz Reşat Sipahi Polymyxin Including Therapy Versus Colistin Including Therapy In The Therapy Of Carbapenem-Resistant Gram-Negative Infections: A Retrospective Matched Cohort Study Journal of Global Antimicrobial Resistance polymyxin multidrug resistance carbapenem resistance |
| title | Polymyxin Including Therapy Versus Colistin Including Therapy In The Therapy Of Carbapenem-Resistant Gram-Negative Infections: A Retrospective Matched Cohort Study |
| title_full | Polymyxin Including Therapy Versus Colistin Including Therapy In The Therapy Of Carbapenem-Resistant Gram-Negative Infections: A Retrospective Matched Cohort Study |
| title_fullStr | Polymyxin Including Therapy Versus Colistin Including Therapy In The Therapy Of Carbapenem-Resistant Gram-Negative Infections: A Retrospective Matched Cohort Study |
| title_full_unstemmed | Polymyxin Including Therapy Versus Colistin Including Therapy In The Therapy Of Carbapenem-Resistant Gram-Negative Infections: A Retrospective Matched Cohort Study |
| title_short | Polymyxin Including Therapy Versus Colistin Including Therapy In The Therapy Of Carbapenem-Resistant Gram-Negative Infections: A Retrospective Matched Cohort Study |
| title_sort | polymyxin including therapy versus colistin including therapy in the therapy of carbapenem resistant gram negative infections a retrospective matched cohort study |
| topic | polymyxin multidrug resistance carbapenem resistance |
| url | http://www.sciencedirect.com/science/article/pii/S221371652400184X |
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