Serum leptin level positively correlates with metabolic syndrome among elderly Taiwanese
Objective: Leptin is an adipocyte-derived hormone and has shown positive correlation with obesity and metabolic syndrome (MetS) in many studies. However, there are few studies investigating this relation in elderly people. Therefore, we aimed to investigate the correlation between the fasting serum...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Tzu Chi Medical Journal |
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| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2017;volume=29;issue=3;spage=159;epage=164;aulast=Wang |
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| _version_ | 1850198102186655744 |
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| author | Li-Hsuan Wang Yao-Chang Liu Ji-Hung Wang Chung-Jen Lee Bang-Gee Hsu |
| author_facet | Li-Hsuan Wang Yao-Chang Liu Ji-Hung Wang Chung-Jen Lee Bang-Gee Hsu |
| author_sort | Li-Hsuan Wang |
| collection | DOAJ |
| description | Objective: Leptin is an adipocyte-derived hormone and has shown positive correlation with obesity and metabolic syndrome (MetS) in many studies. However, there are few studies investigating this relation in elderly people. Therefore, we aimed to investigate the correlation between the fasting serum leptin level and MetS among older Taiwanese. Materials and Methods: The fasting serum leptin level was obtained from 62 Taiwanese participants over 65 years old and was measured using a commercially available enzyme immunoassay kit. MetS and its components were defined using diagnostic criteria from the International Diabetes Federation. Results: Thirty elderly participants (48.4%) had MetS. The serum leptin level was positively correlated with MetS (P < 0.001). Multivariate logistic regression analysis of the factors significantly associated with MetS showed that logarithmically transformed leptin (log-leptin, each increase 0.1 ng/mL log-leptin, odds ratio: 1.276, 95% confidence interval: 1.015–1.603,P= 0.037) was still an independent predictor of MetS in elderly persons. Univariable linear analysis showed that body weight (r = 0280,P= 0.028), body mass index (r = 0.417,P= 0.001), waist circumference (r = 0.419,P= 0.001), blood urea nitrogen (r = 0255,P= 0.046), log-insulin (r = 0436,P< 0.001), and logarithmically transformed homeostasis model assessment of insulin resistance (r = 0359,P= 0.004) positively correlated with fasting serum log-leptin levels. Multivariate forward stepwise linear regression analysis of the factors significantly associated with fasting serum log-leptin levels revealed that waist circumference (adjusted R2 = 0.083,P= 0.002), statin use (adjusted R2 = 0.058,P= 0.016), and female gender (adjusted R2 = 0.041,P= 0.034) were independent predictors of fasting serum log-leptin levels among elderly participants. Conclusion: In elderly Taiwanese, the serum leptin level was positively correlated with MetS. Waist circumference, statin use, and female gender were independent predictors of the fasting serum leptin level in elderly participants. |
| format | Article |
| id | doaj-art-a3df3768fb7c46d6855cc285a4be27f9 |
| institution | OA Journals |
| issn | 1016-3190 2223-8956 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu Chi Medical Journal |
| spelling | doaj-art-a3df3768fb7c46d6855cc285a4be27f92025-08-20T02:12:58ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562017-01-0129315916410.4103/tcmj.tcmj_60_17Serum leptin level positively correlates with metabolic syndrome among elderly TaiwaneseLi-Hsuan WangYao-Chang LiuJi-Hung WangChung-Jen LeeBang-Gee HsuObjective: Leptin is an adipocyte-derived hormone and has shown positive correlation with obesity and metabolic syndrome (MetS) in many studies. However, there are few studies investigating this relation in elderly people. Therefore, we aimed to investigate the correlation between the fasting serum leptin level and MetS among older Taiwanese. Materials and Methods: The fasting serum leptin level was obtained from 62 Taiwanese participants over 65 years old and was measured using a commercially available enzyme immunoassay kit. MetS and its components were defined using diagnostic criteria from the International Diabetes Federation. Results: Thirty elderly participants (48.4%) had MetS. The serum leptin level was positively correlated with MetS (P < 0.001). Multivariate logistic regression analysis of the factors significantly associated with MetS showed that logarithmically transformed leptin (log-leptin, each increase 0.1 ng/mL log-leptin, odds ratio: 1.276, 95% confidence interval: 1.015–1.603,P= 0.037) was still an independent predictor of MetS in elderly persons. Univariable linear analysis showed that body weight (r = 0280,P= 0.028), body mass index (r = 0.417,P= 0.001), waist circumference (r = 0.419,P= 0.001), blood urea nitrogen (r = 0255,P= 0.046), log-insulin (r = 0436,P< 0.001), and logarithmically transformed homeostasis model assessment of insulin resistance (r = 0359,P= 0.004) positively correlated with fasting serum log-leptin levels. Multivariate forward stepwise linear regression analysis of the factors significantly associated with fasting serum log-leptin levels revealed that waist circumference (adjusted R2 = 0.083,P= 0.002), statin use (adjusted R2 = 0.058,P= 0.016), and female gender (adjusted R2 = 0.041,P= 0.034) were independent predictors of fasting serum log-leptin levels among elderly participants. Conclusion: In elderly Taiwanese, the serum leptin level was positively correlated with MetS. Waist circumference, statin use, and female gender were independent predictors of the fasting serum leptin level in elderly participants.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2017;volume=29;issue=3;spage=159;epage=164;aulast=WangElderlyLeptinMetabolic syndrome |
| spellingShingle | Li-Hsuan Wang Yao-Chang Liu Ji-Hung Wang Chung-Jen Lee Bang-Gee Hsu Serum leptin level positively correlates with metabolic syndrome among elderly Taiwanese Tzu Chi Medical Journal Elderly Leptin Metabolic syndrome |
| title | Serum leptin level positively correlates with metabolic syndrome among elderly Taiwanese |
| title_full | Serum leptin level positively correlates with metabolic syndrome among elderly Taiwanese |
| title_fullStr | Serum leptin level positively correlates with metabolic syndrome among elderly Taiwanese |
| title_full_unstemmed | Serum leptin level positively correlates with metabolic syndrome among elderly Taiwanese |
| title_short | Serum leptin level positively correlates with metabolic syndrome among elderly Taiwanese |
| title_sort | serum leptin level positively correlates with metabolic syndrome among elderly taiwanese |
| topic | Elderly Leptin Metabolic syndrome |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2017;volume=29;issue=3;spage=159;epage=164;aulast=Wang |
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