Sparstolonin B nano-formulation attenuates LPS-induced lung injury

Sparstolonin B nano-formulation attenuates LPS-induced lung injury

IntroductionNanomedicines can improve drug delivery and efficacy while reducing side effects. Our study examines the impact of a nano-formulation of Sparstolonin B (nSsnB), a TLR-4 antagonist, on LPS-induced inflammation in RAW264.7 cells and lung injury in mice.MethodsRAW264.7 cells were treated wi...

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Bibliographic Details
Main Authors:	Qinghe Meng, Xiaojing Wang, Dandan Guo, Gary Zhang, Changying Shi, Adam Novak, Xiguang Yang, Juntao Luo, Robert N. Cooney
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Pharmacology
Subjects:	sparstolonin B (nSsnB) LPS ALI/ARDS TLR-4 NF-κB inflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1532391/full
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