CCDC68 Maintains Mitotic Checkpoint Activation by Promoting CDC20 Integration into the MCC

CCDC68 Maintains Mitotic Checkpoint Activation by Promoting CDC20 Integration into the MCC

Abstract The spindle assembly checkpoint (SAC) ensures chromosome segregation fidelity by manipulating unattached kinetochore‐dependent assembly of the mitotic checkpoint complex (MCC). The MCC binds to and inhibits the anaphase promoting complex/cyclosome (APC/C) to postpone mitotic exit. However,...

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Bibliographic Details
Main Authors: Qi Li, Qingzhou Chen, Tao Zheng, Fulin Wang, Junlin Teng, Haining Zhou, Jianguo Chen
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Advanced Science
Subjects:
CCDC68
CDC20
kinetochore
mitotic checkpoint complex
spindle assembly checkpoint
Online Access:https://doi.org/10.1002/advs.202406009
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