Tangeretin Suppresses Fumonisin Production by Modulating an NmrA- and HSCARG-like Protein in <i>Fusarium verticillioides</i>
Fumonisins are polyketide-derived mycotoxins posing significant health threats to humans and animals. Among these, fumonisin B<sub>1</sub> (FB<sub>1</sub>) is the most prevalent mycotoxin, primarily produced by <i>Fusarium verticillioides</i>, especially in maize...
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MDPI AG
2025-04-01
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| author | Liuqing Wang Wenlei Zhai Dongmei Jiang Nan Jiang Jiaqi Yan Haoyun Jiang Meng Wang |
| author_facet | Liuqing Wang Wenlei Zhai Dongmei Jiang Nan Jiang Jiaqi Yan Haoyun Jiang Meng Wang |
| author_sort | Liuqing Wang |
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| description | Fumonisins are polyketide-derived mycotoxins posing significant health threats to humans and animals. Among these, fumonisin B<sub>1</sub> (FB<sub>1</sub>) is the most prevalent mycotoxin, primarily produced by <i>Fusarium verticillioides</i>, especially in maize and its derived products. Tangeretin, a polymethoxyflavonoid, has been identified as having potential medicinal properties, particularly as an antioxidant. To evaluate the antifungal and anti-mycotoxigenic properties of tangeretin and to elucidate the mechanisms underlying its inhibitory effects, assessments of fungal growth, FB<sub>1</sub> production, conidial germination, and cellulase activity, antioxidant capacity and enzyme activities, transcriptomic analysis and gene deletion experiments were conducted. Consequently, tangeretin significantly curtailed fungal growth and FB<sub>1</sub> production and provided protection against pathogenic infection on corn. It affected genes associated with fungal growth, conidial development, and antioxidant response. Furthermore, tangeretin interfered with the supply of biosynthetic substrate necessary for fumonisin production, particularly impacting pathways involved in alanine metabolism, pyruvate metabolism, fatty acid degradation, and sphingolipid metabolism. Notably, tangeretin downregulated four biosynthetic genes (<i>Fum2</i>, <i>Fum3</i>, <i>Fum10</i> and <i>Fum11</i>) that are involved in the final steps of fumonisin formation. It likely disrupted the MAPK signaling pathway and targeted a putative NmrA- and HSCARG-like protein Fv_Tan1, which was identified as having positive effects on fungal growth and mycotoxin biosynthesis. This study presents a promising approach for controlling fumonisin contamination in agricultural settings. |
| format | Article |
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| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Journal of Fungi |
| spelling | doaj-art-a3d63c42f40d44b08a21b2c8e2fd24492025-08-20T02:18:03ZengMDPI AGJournal of Fungi2309-608X2025-04-0111431310.3390/jof11040313Tangeretin Suppresses Fumonisin Production by Modulating an NmrA- and HSCARG-like Protein in <i>Fusarium verticillioides</i>Liuqing Wang0Wenlei Zhai1Dongmei Jiang2Nan Jiang3Jiaqi Yan4Haoyun Jiang5Meng Wang6Institute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, No. 9 Middle Road of Shuguanghuayuan, Haidian District, Beijing 100097, ChinaInstitute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, No. 9 Middle Road of Shuguanghuayuan, Haidian District, Beijing 100097, ChinaInstitute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, No. 9 Middle Road of Shuguanghuayuan, Haidian District, Beijing 100097, ChinaInstitute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, No. 9 Middle Road of Shuguanghuayuan, Haidian District, Beijing 100097, ChinaCollege of Horticulture, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, ChinaInstitute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, No. 9 Middle Road of Shuguanghuayuan, Haidian District, Beijing 100097, ChinaInstitute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, No. 9 Middle Road of Shuguanghuayuan, Haidian District, Beijing 100097, ChinaFumonisins are polyketide-derived mycotoxins posing significant health threats to humans and animals. Among these, fumonisin B<sub>1</sub> (FB<sub>1</sub>) is the most prevalent mycotoxin, primarily produced by <i>Fusarium verticillioides</i>, especially in maize and its derived products. Tangeretin, a polymethoxyflavonoid, has been identified as having potential medicinal properties, particularly as an antioxidant. To evaluate the antifungal and anti-mycotoxigenic properties of tangeretin and to elucidate the mechanisms underlying its inhibitory effects, assessments of fungal growth, FB<sub>1</sub> production, conidial germination, and cellulase activity, antioxidant capacity and enzyme activities, transcriptomic analysis and gene deletion experiments were conducted. Consequently, tangeretin significantly curtailed fungal growth and FB<sub>1</sub> production and provided protection against pathogenic infection on corn. It affected genes associated with fungal growth, conidial development, and antioxidant response. Furthermore, tangeretin interfered with the supply of biosynthetic substrate necessary for fumonisin production, particularly impacting pathways involved in alanine metabolism, pyruvate metabolism, fatty acid degradation, and sphingolipid metabolism. Notably, tangeretin downregulated four biosynthetic genes (<i>Fum2</i>, <i>Fum3</i>, <i>Fum10</i> and <i>Fum11</i>) that are involved in the final steps of fumonisin formation. It likely disrupted the MAPK signaling pathway and targeted a putative NmrA- and HSCARG-like protein Fv_Tan1, which was identified as having positive effects on fungal growth and mycotoxin biosynthesis. This study presents a promising approach for controlling fumonisin contamination in agricultural settings.https://www.mdpi.com/2309-608X/11/4/313fumonisinmycotoxin<i>Fusarium verticillioides</i>tangeretinflavonoid |
| spellingShingle | Liuqing Wang Wenlei Zhai Dongmei Jiang Nan Jiang Jiaqi Yan Haoyun Jiang Meng Wang Tangeretin Suppresses Fumonisin Production by Modulating an NmrA- and HSCARG-like Protein in <i>Fusarium verticillioides</i> Journal of Fungi fumonisin mycotoxin <i>Fusarium verticillioides</i> tangeretin flavonoid |
| title | Tangeretin Suppresses Fumonisin Production by Modulating an NmrA- and HSCARG-like Protein in <i>Fusarium verticillioides</i> |
| title_full | Tangeretin Suppresses Fumonisin Production by Modulating an NmrA- and HSCARG-like Protein in <i>Fusarium verticillioides</i> |
| title_fullStr | Tangeretin Suppresses Fumonisin Production by Modulating an NmrA- and HSCARG-like Protein in <i>Fusarium verticillioides</i> |
| title_full_unstemmed | Tangeretin Suppresses Fumonisin Production by Modulating an NmrA- and HSCARG-like Protein in <i>Fusarium verticillioides</i> |
| title_short | Tangeretin Suppresses Fumonisin Production by Modulating an NmrA- and HSCARG-like Protein in <i>Fusarium verticillioides</i> |
| title_sort | tangeretin suppresses fumonisin production by modulating an nmra and hscarg like protein in i fusarium verticillioides i |
| topic | fumonisin mycotoxin <i>Fusarium verticillioides</i> tangeretin flavonoid |
| url | https://www.mdpi.com/2309-608X/11/4/313 |
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