Impact of image reconstruction on cerebral blood flow measured with 15O-water positron emission tomography
Abstract Background 15O-water positron emission tomography (PET) is considered the gold standard method for non-invasive measurement of cerebral blood flow (CBF). However, previously published average CBF values in healthy subjects have varied greatly and the cause of these variations remains unclea...
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| Language: | English |
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SpringerOpen
2025-06-01
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| Series: | EJNMMI Physics |
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| Online Access: | https://doi.org/10.1186/s40658-025-00760-5 |
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| author | Elin Bäck My Jonasson Elin Lindström Andreas Tolf Joachim Burman Lieuwe Appel Mark Lubberink |
| author_facet | Elin Bäck My Jonasson Elin Lindström Andreas Tolf Joachim Burman Lieuwe Appel Mark Lubberink |
| author_sort | Elin Bäck |
| collection | DOAJ |
| description | Abstract Background 15O-water positron emission tomography (PET) is considered the gold standard method for non-invasive measurement of cerebral blood flow (CBF). However, previously published average CBF values in healthy subjects have varied greatly and the cause of these variations remains unclear. This study investigates how image reconstruction methods and spatial resolution affect CBF measurements with 15O-water PET. Methods Eight healthy subjects each underwent dynamic 15O-water PET scans with continuous arterial blood sampling. Images were reconstructed using two different algorithms; ordered subset expectation maximisation and block sequential regularised expectation maximalisation with varying reconstruction parameters. CBF was estimated for the whole brain, grey matter, and central white matter. Reconstruction-specific effective spatial resolution was estimated using phantom measurements and simulations. Results The mean whole brain CBF was 0.48 mL/cm3/min and showed little dependence on the image reconstruction method. Grey matter CBF varied between 0.52 and 0.57 mL/cm3/min, and central white matter CBF between 0.20 and 0.28 mL/cm3/min. Regional CBF showed great dependence on effective spatial resolution with a negative correlation between grey matter CBF and resolution (r = -0.96) and a positive correlation between central white matter and resolution (r = 0.93). Conclusion This study concludes that grey matter and central white matter CBF, but not whole brain CBF measured with quantitative 15O-water PET is reconstruction method dependent, mainly due to varying spatial resolution with consequent partial volume effects. Variations in published CBF values cannot be explained solely by reconstruction methods or spatial resolution. |
| format | Article |
| id | doaj-art-a3d3ac81b1d04066a7e5552afa465045 |
| institution | Kabale University |
| issn | 2197-7364 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SpringerOpen |
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| series | EJNMMI Physics |
| spelling | doaj-art-a3d3ac81b1d04066a7e5552afa4650452025-08-20T03:26:47ZengSpringerOpenEJNMMI Physics2197-73642025-06-0112111510.1186/s40658-025-00760-5Impact of image reconstruction on cerebral blood flow measured with 15O-water positron emission tomographyElin Bäck0My Jonasson1Elin Lindström2Andreas Tolf3Joachim Burman4Lieuwe Appel5Mark Lubberink6Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala UniversityMolecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala UniversityMolecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala UniversityTranslational Neurology, Department of Medical Sciences, Uppsala UniversityTranslational Neurology, Department of Medical Sciences, Uppsala UniversityMolecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala UniversityMolecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala UniversityAbstract Background 15O-water positron emission tomography (PET) is considered the gold standard method for non-invasive measurement of cerebral blood flow (CBF). However, previously published average CBF values in healthy subjects have varied greatly and the cause of these variations remains unclear. This study investigates how image reconstruction methods and spatial resolution affect CBF measurements with 15O-water PET. Methods Eight healthy subjects each underwent dynamic 15O-water PET scans with continuous arterial blood sampling. Images were reconstructed using two different algorithms; ordered subset expectation maximisation and block sequential regularised expectation maximalisation with varying reconstruction parameters. CBF was estimated for the whole brain, grey matter, and central white matter. Reconstruction-specific effective spatial resolution was estimated using phantom measurements and simulations. Results The mean whole brain CBF was 0.48 mL/cm3/min and showed little dependence on the image reconstruction method. Grey matter CBF varied between 0.52 and 0.57 mL/cm3/min, and central white matter CBF between 0.20 and 0.28 mL/cm3/min. Regional CBF showed great dependence on effective spatial resolution with a negative correlation between grey matter CBF and resolution (r = -0.96) and a positive correlation between central white matter and resolution (r = 0.93). Conclusion This study concludes that grey matter and central white matter CBF, but not whole brain CBF measured with quantitative 15O-water PET is reconstruction method dependent, mainly due to varying spatial resolution with consequent partial volume effects. Variations in published CBF values cannot be explained solely by reconstruction methods or spatial resolution.https://doi.org/10.1186/s40658-025-00760-515O-waterCerebral blood flowImage reconstructionNeuroimagingPositron emission tomography |
| spellingShingle | Elin Bäck My Jonasson Elin Lindström Andreas Tolf Joachim Burman Lieuwe Appel Mark Lubberink Impact of image reconstruction on cerebral blood flow measured with 15O-water positron emission tomography EJNMMI Physics 15O-water Cerebral blood flow Image reconstruction Neuroimaging Positron emission tomography |
| title | Impact of image reconstruction on cerebral blood flow measured with 15O-water positron emission tomography |
| title_full | Impact of image reconstruction on cerebral blood flow measured with 15O-water positron emission tomography |
| title_fullStr | Impact of image reconstruction on cerebral blood flow measured with 15O-water positron emission tomography |
| title_full_unstemmed | Impact of image reconstruction on cerebral blood flow measured with 15O-water positron emission tomography |
| title_short | Impact of image reconstruction on cerebral blood flow measured with 15O-water positron emission tomography |
| title_sort | impact of image reconstruction on cerebral blood flow measured with 15o water positron emission tomography |
| topic | 15O-water Cerebral blood flow Image reconstruction Neuroimaging Positron emission tomography |
| url | https://doi.org/10.1186/s40658-025-00760-5 |
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