ASSESSMENT OF RECEPTOR CONVERSION ROLE FOR ADVANCED BREAST CANCER ON THE CHEMORESISTANCE OCCURRENCE
Introduction. Neoadjuvant chemotherapy (NC) is employed as an important step in the treatment of patients with breast cancer (BC). We do not have much information about the conversion of estrogen receptor (ER) and/or progesterone receptor (PR) status in breast cancer (BC) patients after NC, or about...
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State Institution of Science «Research and Practical Center of Preventive and Clinical Medicine» State Administrative Department
2025-03-01
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| Series: | Клінічна та профілактична медицина |
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| Online Access: | https://cp-medical.com/index.php/journal/article/view/554 |
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| author | Oleksii V. Movchan Ivan I. Smolanka Andriy O. Lyashenko Anton D. Loboda Iryna V. Dosenko Oksana M. Ivankova |
| author_facet | Oleksii V. Movchan Ivan I. Smolanka Andriy O. Lyashenko Anton D. Loboda Iryna V. Dosenko Oksana M. Ivankova |
| author_sort | Oleksii V. Movchan |
| collection | DOAJ |
| description | Introduction. Neoadjuvant chemotherapy (NC) is employed as an important step in the treatment of patients with breast cancer (BC). We do not have much information about the conversion of estrogen receptor (ER) and/or progesterone receptor (PR) status in breast cancer (BC) patients after NC, or about its correlation with chemoresistance and prognosis. Not all clinics consistently determine receptor status after neoadjuvant chemotherapy (NC) and surgical intervention in breast cancer (BC) patients. However, this status may vary, making it critical to adjust the adjuvant treatment plan accordingly. Failure to do so may result in inadequate therapy and the development of chemoresistance.
Aim. To determine the effect of changes in receptor status at different stages of breast cancer treatment on the development of chemoresistance.
Materials and methods. Sixty patients with advanced breast cancer after neoadjuvant chemotherapy (NAC) were enrolled in the study and divided into two groups: the receptor-stable group (30 patients, with no conversion in ER and PR receptor status before and after NAC) and the receptor-conversion group (30 patients, with conversion in either ER or PR status). Univariate analysis was used to compare 5-year disease-free survival (DFS) between the groups.
Results. The estimated 5-year DFS rate for patients in the receptor-stable group was significantly higher (22 patients, 73.7%) compared to the receptor-conversion group (16 patients, 55.2%, P = 0.015). In contrast, the estimated 5-year overall survival (OS) rates for patients with or without receptor conversion were not statistically different (80.0% vs. 72.4%, log-rank test, P = 0.587). In the univariate Cox proportional hazards analysis, patients with receptor conversion had worse DFS (hazard ratio, 1.995; 95% confidence interval, 1.130–3.521, P = 0.031).
Conclusions. We strongly recommend testing patients’ biomarkers at different stages of treatment and paying closer attention to those with receptor conversion. These patients require an individualised approach to therapy as part of comprehensive treatment. It is essential to determine hormonal status after neoadjuvant therapy, using postoperative tissue samples, as hormonal status may change and, accordingly, treatment strategies may need to be adjusted. This approach can help prevent the development of chemoresistance. |
| format | Article |
| id | doaj-art-a3d2f7c38d984a4683572228d9d9ea42 |
| institution | OA Journals |
| issn | 2616-4868 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | State Institution of Science «Research and Practical Center of Preventive and Clinical Medicine» State Administrative Department |
| record_format | Article |
| series | Клінічна та профілактична медицина |
| spelling | doaj-art-a3d2f7c38d984a4683572228d9d9ea422025-08-20T02:34:31ZengState Institution of Science «Research and Practical Center of Preventive and Clinical Medicine» State Administrative DepartmentКлінічна та профілактична медицина2616-48682025-03-013566210.31612/2616-4868.3.2025.07554ASSESSMENT OF RECEPTOR CONVERSION ROLE FOR ADVANCED BREAST CANCER ON THE CHEMORESISTANCE OCCURRENCEOleksii V. Movchan0Ivan I. Smolanka1Andriy O. Lyashenko2Anton D. Loboda3Iryna V. Dosenko4Oksana M. Ivankova5State Non-commercial Enterprise “National Cancer Institute” of the Ministry of Health of Ukraine, Kyiv, UkraineState Non-commercial Enterprise “National Cancer Institute” of the Ministry of Health of Ukraine, Kyiv, UkraineState Non-commercial Enterprise “National Cancer Institute” of the Ministry of Health of Ukraine, Kyiv, UkraineState Non-commercial Enterprise “National Cancer Institute” of the Ministry of Health of Ukraine, Kyiv, UkraineState Non-commercial Enterprise “National Cancer Institute” of the Ministry of Health of Ukraine, Kyiv, UkraineState Non-commercial Enterprise “National Cancer Institute” of the Ministry of Health of Ukraine, Kyiv, UkraineIntroduction. Neoadjuvant chemotherapy (NC) is employed as an important step in the treatment of patients with breast cancer (BC). We do not have much information about the conversion of estrogen receptor (ER) and/or progesterone receptor (PR) status in breast cancer (BC) patients after NC, or about its correlation with chemoresistance and prognosis. Not all clinics consistently determine receptor status after neoadjuvant chemotherapy (NC) and surgical intervention in breast cancer (BC) patients. However, this status may vary, making it critical to adjust the adjuvant treatment plan accordingly. Failure to do so may result in inadequate therapy and the development of chemoresistance. Aim. To determine the effect of changes in receptor status at different stages of breast cancer treatment on the development of chemoresistance. Materials and methods. Sixty patients with advanced breast cancer after neoadjuvant chemotherapy (NAC) were enrolled in the study and divided into two groups: the receptor-stable group (30 patients, with no conversion in ER and PR receptor status before and after NAC) and the receptor-conversion group (30 patients, with conversion in either ER or PR status). Univariate analysis was used to compare 5-year disease-free survival (DFS) between the groups. Results. The estimated 5-year DFS rate for patients in the receptor-stable group was significantly higher (22 patients, 73.7%) compared to the receptor-conversion group (16 patients, 55.2%, P = 0.015). In contrast, the estimated 5-year overall survival (OS) rates for patients with or without receptor conversion were not statistically different (80.0% vs. 72.4%, log-rank test, P = 0.587). In the univariate Cox proportional hazards analysis, patients with receptor conversion had worse DFS (hazard ratio, 1.995; 95% confidence interval, 1.130–3.521, P = 0.031). Conclusions. We strongly recommend testing patients’ biomarkers at different stages of treatment and paying closer attention to those with receptor conversion. These patients require an individualised approach to therapy as part of comprehensive treatment. It is essential to determine hormonal status after neoadjuvant therapy, using postoperative tissue samples, as hormonal status may change and, accordingly, treatment strategies may need to be adjusted. This approach can help prevent the development of chemoresistance.https://cp-medical.com/index.php/journal/article/view/554breast cancerneoadjuvant chemotherapyreceptor conversionchemoresistance |
| spellingShingle | Oleksii V. Movchan Ivan I. Smolanka Andriy O. Lyashenko Anton D. Loboda Iryna V. Dosenko Oksana M. Ivankova ASSESSMENT OF RECEPTOR CONVERSION ROLE FOR ADVANCED BREAST CANCER ON THE CHEMORESISTANCE OCCURRENCE Клінічна та профілактична медицина breast cancer neoadjuvant chemotherapy receptor conversion chemoresistance |
| title | ASSESSMENT OF RECEPTOR CONVERSION ROLE FOR ADVANCED BREAST CANCER ON THE CHEMORESISTANCE OCCURRENCE |
| title_full | ASSESSMENT OF RECEPTOR CONVERSION ROLE FOR ADVANCED BREAST CANCER ON THE CHEMORESISTANCE OCCURRENCE |
| title_fullStr | ASSESSMENT OF RECEPTOR CONVERSION ROLE FOR ADVANCED BREAST CANCER ON THE CHEMORESISTANCE OCCURRENCE |
| title_full_unstemmed | ASSESSMENT OF RECEPTOR CONVERSION ROLE FOR ADVANCED BREAST CANCER ON THE CHEMORESISTANCE OCCURRENCE |
| title_short | ASSESSMENT OF RECEPTOR CONVERSION ROLE FOR ADVANCED BREAST CANCER ON THE CHEMORESISTANCE OCCURRENCE |
| title_sort | assessment of receptor conversion role for advanced breast cancer on the chemoresistance occurrence |
| topic | breast cancer neoadjuvant chemotherapy receptor conversion chemoresistance |
| url | https://cp-medical.com/index.php/journal/article/view/554 |
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