The impact of Naples prognostic score on cognitive impairment in hemodialysis patients: a multicenter study
Background Malnutrition and inflammation are prevalent in hemodialysis (HD) patients and linked to cognitive impairment (CI). Naples prognostic score (NPS) is a comprehensive measure of patients’ inflammation and nutritional status. This study is to evaluate the association of NPS and CI risk in HD...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2515531 |
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| author | Yan Ran Yuqi Yang Yanzhe Peng Jingjing Da Zuping Qian Jing Yuan Yan Zha |
| author_facet | Yan Ran Yuqi Yang Yanzhe Peng Jingjing Da Zuping Qian Jing Yuan Yan Zha |
| author_sort | Yan Ran |
| collection | DOAJ |
| description | Background Malnutrition and inflammation are prevalent in hemodialysis (HD) patients and linked to cognitive impairment (CI). Naples prognostic score (NPS) is a comprehensive measure of patients’ inflammation and nutritional status. This study is to evaluate the association of NPS and CI risk in HD patients.Methods Two thousand seven hundred twenty-five HD patients were recruited and NPS score obtained based on albumin, total cholesterol (TC), lymphocytes, neutrophils, and monocytes. Cognitive function was assessed with Mini-Mental State Examination score (MMSE). Logistic regression models, interactive analyses were conducted.Results Among 2725 HD patients, the prevalence of CI is 33.8%, the mean MMSE score was 26.9 ± 3.9. After adjusting clinical confounders, NPS showed a positive associated with CI both as a continuous variable (OR = 1.120, 95% CI 1.029–1.221, p = 0.009) and as a categorical variable (OR = 1.552, 95%CI: 1.146–2.110, p = 0.005). The analysis revealed a negative correlation between NPS and MMSE scores, observed both as a continuous variable (β = –0.178, 95% CI −0.321 to −0.035, p = 0.015) and as a categorical variable. Higher NPS was significantly associated with increased dementia risk (adjusted OR = 1.153, 95% CI 1.035–1.286, p = 0.010). Among CI patients, the proportion of males was higher than that of females. Subgroup analysis showed that the effect of NPS on CI was more pronounced in individuals under 65 years, without diabetes and cerebrovascular disease (CVD). Except for males, low education level, non-CVD, and HD frequency less than three times per week, the association between NPS and dementia was more significant.Conclusions NPS was associated with cognitive impairment in HD patients with a positive dose-response effect. |
| format | Article |
| id | doaj-art-a3ce30bccebd4227be58b29050dc19e2 |
| institution | OA Journals |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-a3ce30bccebd4227be58b29050dc19e22025-08-20T02:34:20ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2515531The impact of Naples prognostic score on cognitive impairment in hemodialysis patients: a multicenter studyYan Ran0Yuqi Yang1Yanzhe Peng2Jingjing Da3Zuping Qian4Jing Yuan5Yan Zha6Zunyi Medical University, Zunyi, ChinaDepartment of Nephrology, Guizhou Provincial People′s Hospital, Guiyang, ChinaDepartment of Nephrology, Guizhou Provincial People′s Hospital, Guiyang, ChinaDepartment of Nephrology, Guizhou Provincial People′s Hospital, Guiyang, ChinaDepartment of Nephrology, Guizhou Provincial People′s Hospital, Guiyang, ChinaDepartment of Nephrology, Guizhou Provincial People′s Hospital, Guiyang, ChinaDepartment of Nephrology, Guizhou Provincial People′s Hospital, Guiyang, ChinaBackground Malnutrition and inflammation are prevalent in hemodialysis (HD) patients and linked to cognitive impairment (CI). Naples prognostic score (NPS) is a comprehensive measure of patients’ inflammation and nutritional status. This study is to evaluate the association of NPS and CI risk in HD patients.Methods Two thousand seven hundred twenty-five HD patients were recruited and NPS score obtained based on albumin, total cholesterol (TC), lymphocytes, neutrophils, and monocytes. Cognitive function was assessed with Mini-Mental State Examination score (MMSE). Logistic regression models, interactive analyses were conducted.Results Among 2725 HD patients, the prevalence of CI is 33.8%, the mean MMSE score was 26.9 ± 3.9. After adjusting clinical confounders, NPS showed a positive associated with CI both as a continuous variable (OR = 1.120, 95% CI 1.029–1.221, p = 0.009) and as a categorical variable (OR = 1.552, 95%CI: 1.146–2.110, p = 0.005). The analysis revealed a negative correlation between NPS and MMSE scores, observed both as a continuous variable (β = –0.178, 95% CI −0.321 to −0.035, p = 0.015) and as a categorical variable. Higher NPS was significantly associated with increased dementia risk (adjusted OR = 1.153, 95% CI 1.035–1.286, p = 0.010). Among CI patients, the proportion of males was higher than that of females. Subgroup analysis showed that the effect of NPS on CI was more pronounced in individuals under 65 years, without diabetes and cerebrovascular disease (CVD). Except for males, low education level, non-CVD, and HD frequency less than three times per week, the association between NPS and dementia was more significant.Conclusions NPS was associated with cognitive impairment in HD patients with a positive dose-response effect.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2515531Naples prognostic score (NPS)cognitive impairment (CI)hemodialysisdementia |
| spellingShingle | Yan Ran Yuqi Yang Yanzhe Peng Jingjing Da Zuping Qian Jing Yuan Yan Zha The impact of Naples prognostic score on cognitive impairment in hemodialysis patients: a multicenter study Renal Failure Naples prognostic score (NPS) cognitive impairment (CI) hemodialysis dementia |
| title | The impact of Naples prognostic score on cognitive impairment in hemodialysis patients: a multicenter study |
| title_full | The impact of Naples prognostic score on cognitive impairment in hemodialysis patients: a multicenter study |
| title_fullStr | The impact of Naples prognostic score on cognitive impairment in hemodialysis patients: a multicenter study |
| title_full_unstemmed | The impact of Naples prognostic score on cognitive impairment in hemodialysis patients: a multicenter study |
| title_short | The impact of Naples prognostic score on cognitive impairment in hemodialysis patients: a multicenter study |
| title_sort | impact of naples prognostic score on cognitive impairment in hemodialysis patients a multicenter study |
| topic | Naples prognostic score (NPS) cognitive impairment (CI) hemodialysis dementia |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2515531 |
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