Evaluation of efficacy and safety of oral capsule fecal microbiota transplantation for the treatment of refractory functional constipation
[Objectives] To observe the efficacy and safety of oral capsule fecal microbiota transplantation (FMT) in the treatment of refractory functional constipation. [Methods] A total of 36 patients with refractory functional constipation admitted to the Department of Defecation Disorders, Shenyang Anorect...
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Editorial Office of Journal of Colorectal & Anal Surgery
2024-06-01
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| Series: | 结直肠肛门外科 |
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| Online Access: | https://jcas.gxmuyfy.cn/cn/wqll/paper.html?id=280&cateName=2024%E5%B9%B4%20%E7%AC%AC30%E5%8D%B7%20%E7%AC%AC3%E6%9C%9F |
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| author | Zhang Yong Zhang Chunxia Gao Ge Zhang Luyi Zeng Xiandong |
| author_facet | Zhang Yong Zhang Chunxia Gao Ge Zhang Luyi Zeng Xiandong |
| author_sort | Zhang Yong |
| collection | DOAJ |
| description | [Objectives] To observe the efficacy and safety of oral capsule fecal microbiota transplantation (FMT) in the treatment of refractory functional constipation. [Methods] A total of 36 patients with refractory functional constipation admitted to the Department of Defecation Disorders, Shenyang Anorectal Hospital, were enrolled and treated with oral capsule FMT. The number of patients with bowel movements > 3 times/week and stool consistency of Bristol type 3 or 4 was recorded before treatment, 1 month after treatment, and 6 months after treatment. The Constipation System Score (CSS) and the Patient Assessment of Constipation Quality of Life Score (PAC-Qol) were administered. Analyze the defecation situation and clinical efficacy of patients. [Results] The number of patients with bowel movements > 3 times/week before FMT, 1 month after FMT, and 6 months after FMT were 13 (36.1%), 23 (63.9%), and 22 (61.1%), respectively. The number of patients with Bristol type 3 or 4 stool consistency were 9 (25%), 24 (66.7%), and 16 (44.4%), respectively. The CSS and the PAC-Qol were significantly lower at 1 month and 6 months post-FMT compared to pre-FMT (P<0.05). After 1 month of FMT, 5 patients were cured, 11 showed marked improvement, 11 were effective, and 9 were ineffective, with an overall effective rate of 75%. After 6 months of FMT, 6 patients were cured, 5 showed marked improvement, 9 were effective, and 16 were ineffective, with an overall effective rate of 55.6%. There was no significant difference in the overall effective rate between 1 month and 6 months (P>0.999). Based on the outcomes at 6 months, patients were classified into an effective group (n=20) and an ineffective group (n=16). There was no significant difference in gender composition, age, and history of laxative dependence between the two groups (P>0.05). The course of illness in the ineffective group was longer than that in the effective group, and the difference was statistically significant (P<0.05). No serious adverse reactions occurred during or after FMT. Mild abdominal pain and bloating occurred in 2 patients (5.6%), and mild diarrhea in 2 other patients, all of which resolved without treatment. [Conclusion] Oral capsule FMT is effective and safe for the treatment of refractory functional constipation, and its therapeutic effect is related to the course of the disease. |
| format | Article |
| id | doaj-art-a3cdb544ea7e47458f09dd9b28236801 |
| institution | OA Journals |
| issn | 1674-0491 |
| language | zho |
| publishDate | 2024-06-01 |
| publisher | Editorial Office of Journal of Colorectal & Anal Surgery |
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| series | 结直肠肛门外科 |
| spelling | doaj-art-a3cdb544ea7e47458f09dd9b282368012025-08-20T02:31:02ZzhoEditorial Office of Journal of Colorectal & Anal Surgery结直肠肛门外科1674-04912024-06-0130334434810.19668/j.cnki.issn1674-0491.2024.03.017Evaluation of efficacy and safety of oral capsule fecal microbiota transplantation for the treatment of refractory functional constipationZhang Yong0Zhang Chunxia1Gao Ge2Zhang Luyi3Zeng Xiandong4Anorectal Diagnosis and Treatment Center, Shenyang Fourth People's Hospital, Shenyang 110082, Liaoning, ChinaAnorectal Diagnosis and Treatment Center, Shenyang Fourth People's Hospital, Shenyang 110082, Liaoning, ChinaDepartment of Defecation Disorders, Shenyang Anorectal Hospital, Shenyang 110054, Liaoning, ChinaAnorectal Diagnosis and Treatment Center, Shenyang Fourth People's Hospital, Shenyang 110082, Liaoning, ChinaAnorectal Diagnosis and Treatment Center, Shenyang Fourth People's Hospital, Shenyang 110082, Liaoning, China[Objectives] To observe the efficacy and safety of oral capsule fecal microbiota transplantation (FMT) in the treatment of refractory functional constipation. [Methods] A total of 36 patients with refractory functional constipation admitted to the Department of Defecation Disorders, Shenyang Anorectal Hospital, were enrolled and treated with oral capsule FMT. The number of patients with bowel movements > 3 times/week and stool consistency of Bristol type 3 or 4 was recorded before treatment, 1 month after treatment, and 6 months after treatment. The Constipation System Score (CSS) and the Patient Assessment of Constipation Quality of Life Score (PAC-Qol) were administered. Analyze the defecation situation and clinical efficacy of patients. [Results] The number of patients with bowel movements > 3 times/week before FMT, 1 month after FMT, and 6 months after FMT were 13 (36.1%), 23 (63.9%), and 22 (61.1%), respectively. The number of patients with Bristol type 3 or 4 stool consistency were 9 (25%), 24 (66.7%), and 16 (44.4%), respectively. The CSS and the PAC-Qol were significantly lower at 1 month and 6 months post-FMT compared to pre-FMT (P<0.05). After 1 month of FMT, 5 patients were cured, 11 showed marked improvement, 11 were effective, and 9 were ineffective, with an overall effective rate of 75%. After 6 months of FMT, 6 patients were cured, 5 showed marked improvement, 9 were effective, and 16 were ineffective, with an overall effective rate of 55.6%. There was no significant difference in the overall effective rate between 1 month and 6 months (P>0.999). Based on the outcomes at 6 months, patients were classified into an effective group (n=20) and an ineffective group (n=16). There was no significant difference in gender composition, age, and history of laxative dependence between the two groups (P>0.05). The course of illness in the ineffective group was longer than that in the effective group, and the difference was statistically significant (P<0.05). No serious adverse reactions occurred during or after FMT. Mild abdominal pain and bloating occurred in 2 patients (5.6%), and mild diarrhea in 2 other patients, all of which resolved without treatment. [Conclusion] Oral capsule FMT is effective and safe for the treatment of refractory functional constipation, and its therapeutic effect is related to the course of the disease.https://jcas.gxmuyfy.cn/cn/wqll/paper.html?id=280&cateName=2024%E5%B9%B4%20%E7%AC%AC30%E5%8D%B7%20%E7%AC%AC3%E6%9C%9Ffunctional constipationfecal microbiota transplantationclinical efficacy |
| spellingShingle | Zhang Yong Zhang Chunxia Gao Ge Zhang Luyi Zeng Xiandong Evaluation of efficacy and safety of oral capsule fecal microbiota transplantation for the treatment of refractory functional constipation 结直肠肛门外科 functional constipation fecal microbiota transplantation clinical efficacy |
| title | Evaluation of efficacy and safety of oral capsule fecal microbiota transplantation for the treatment of refractory functional constipation |
| title_full | Evaluation of efficacy and safety of oral capsule fecal microbiota transplantation for the treatment of refractory functional constipation |
| title_fullStr | Evaluation of efficacy and safety of oral capsule fecal microbiota transplantation for the treatment of refractory functional constipation |
| title_full_unstemmed | Evaluation of efficacy and safety of oral capsule fecal microbiota transplantation for the treatment of refractory functional constipation |
| title_short | Evaluation of efficacy and safety of oral capsule fecal microbiota transplantation for the treatment of refractory functional constipation |
| title_sort | evaluation of efficacy and safety of oral capsule fecal microbiota transplantation for the treatment of refractory functional constipation |
| topic | functional constipation fecal microbiota transplantation clinical efficacy |
| url | https://jcas.gxmuyfy.cn/cn/wqll/paper.html?id=280&cateName=2024%E5%B9%B4%20%E7%AC%AC30%E5%8D%B7%20%E7%AC%AC3%E6%9C%9F |
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